{"data":{"id":"10.5061/dryad.9cnp5hqmn","type":"dois","attributes":{"doi":"10.5061/dryad.9cnp5hqmn","prefix":"10.5061","suffix":"dryad.9cnp5hqmn","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Feyaerts, Dorien","nameType":"Personal","givenName":"Dorien","familyName":"Feyaerts","affiliation":["Stanford University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-0795-6625","nameIdentifierScheme":"ORCID"}]},{"name":"Hedou, Julien","nameType":"Personal","givenName":"Julien","familyName":"Hedou","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4721-4797","nameIdentifierScheme":"ORCID"}]},{"name":"Gillard, Joshua","nameType":"Personal","givenName":"Joshua","familyName":"Gillard","affiliation":["Radboud Institute for Molecular Life Sciences"],"nameIdentifiers":[]},{"name":"Chen, Han","nameType":"Personal","givenName":"Han","familyName":"Chen","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Tsai, Eileen S.","nameType":"Personal","givenName":"Eileen S.","familyName":"Tsai","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Peterson, Laura S.","nameType":"Personal","givenName":"Laura S.","familyName":"Peterson","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Ando, Kazuo","nameType":"Personal","givenName":"Kazuo","familyName":"Ando","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Manohar, Monali","nameType":"Personal","givenName":"Monali","familyName":"Manohar","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Do, Evan","nameType":"Personal","givenName":"Evan","familyName":"Do","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Dhondalay, Gopal K.R.","nameType":"Personal","givenName":"Gopal K.R.","familyName":"Dhondalay","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Fitzpatrick, Jessica","nameType":"Personal","givenName":"Jessica","familyName":"Fitzpatrick","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Artandi, Maja","nameType":"Personal","givenName":"Maja","familyName":"Artandi","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Chang, Iris","nameType":"Personal","givenName":"Iris","familyName":"Chang","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Snow, Theo","nameType":"Personal","givenName":"Theo","familyName":"Snow","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Chinthrajah, R. 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Daniel","nameType":"Personal","givenName":"J. Daniel","familyName":"Kelly","affiliation":["University of California San Francisco Medical Center"],"nameIdentifiers":[]},{"name":"Furman, David","nameType":"Personal","givenName":"David","familyName":"Furman","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Aghaeepour, Nima","nameType":"Personal","givenName":"Nima","familyName":"Aghaeepour","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Angst, Martin S.","nameType":"Personal","givenName":"Martin S.","familyName":"Angst","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Boyd, Scott D.","nameType":"Personal","givenName":"Scott D.","familyName":"Boyd","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Pinsky, Benjamin A.","nameType":"Personal","givenName":"Benjamin A.","familyName":"Pinsky","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Nolan, Garry P.","nameType":"Personal","givenName":"Garry P.","familyName":"Nolan","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Nadeau, Kari C.","nameType":"Personal","givenName":"Kari C.","familyName":"Nadeau","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Gaudillière, Brice","nameType":"Personal","givenName":"Brice","familyName":"Gaudillière","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"McIlwain, David R.","nameType":"Personal","givenName":"David R.","familyName":"McIlwain","affiliation":["Stanford Medicine"],"nameIdentifiers":[]}],"titles":[{"title":"Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19"}],"publisher":"Dryad","container":{},"publicationYear":2022,"subjects":[{"subject":"Mass cytometry"},{"subject":"SARS-CoV-2"},{"subject":"Proteomics","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Olink"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2022-06-01T19:44:06Z","dateType":"Submitted"},{"date":"2022-09-02T00:00:00Z","dateType":"Issued"},{"date":"2022-09-02T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1101/2021.02.09.430269","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.1016/j.xcrm.2022.100680","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["17381263372 bytes"],"formats":[],"version":"6","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The biological determinants underlying the range of COVID-19 clinical\n manifestations are not fully understood. Here, over 1400 plasma proteins\n and 2600 single-cell immune features comprising cell phenotype, endogenous\n signaling activity, and signaling responses to inflammatory ligands are\n cross-sectionally assessed in peripheral blood from 97 patients with mild,\n moderate, and severe COVID-19 and 40 uninfected patients. Using an\n integrated computational approach to analyze the combined plasma and\n single-cell proteomic data, we identify and independently validate a\n multivariate model classifying COVID-19 severity (multi-class\n AUCtraining = 0.799, p-value = 4.2e-6; multi-class\n AUCvalidation = 0.773, p-value = 7.7e-6). Examination of\n informative model features reveals novel biological signatures of COVID-19\n severity, including the dysregulation of JAK/STAT, MAPK/mTOR, and NF-κB\n immune signaling networks in addition to recapitulating known hallmarks of\n COVID-19. These results provide a set of early determinants of COVID-19\n severity that may point to therapeutic targets for prevention and/or\n treatment of COVID-19 progression.","descriptionType":"Abstract"},{"description":"Mass cytometry: Blood was collected in EDTA\n tubes. Anticoagulated blood was processed into peripheral blood\n mononuclear cells (PBMC) by density gradient centrifugation using\n published methods (Syed et al., 2014). PBMC were stored in 10% DMSO and\n frozen in liquid nitrogen until thawing and\n staining. \u003cbr\u003eCryopreserved PBMC were quickly thawed, washed two\n times with supplemented medium, and rested for 1h at 37°C in RPMI 1640\n medium supplemented with 10% fetal bovine serum, 1%\n Penicillin-Streptomycin, and 1% L-Glutamine. PBMC were counted and checked\n for viability. 0.5-1x10\u003csup\u003e6\u003c/sup\u003e cells were either\n stimulated with lipopolysaccharide (LPS; 1?g/ml) and CL097 (TLR7/8\n agonist; 1?g/ml), interleukin-2 (IL-2), IL-4, IL-6 and interferon-? (IFN?;\n all 100 ng/ml), a cocktail of phorbol 12-myristate 13-acetate (PMA),\n ionomycin, brefeldin A and monensin (1x; PI cocktail), or left\n unstimulated for 15 minutes at 37°C. After stimulation, samples were fixed\n with Proteomic Stabilizer (SmartTube) and stored at -80°C until further\n processing for mass cytometry analysis.  Plasma\n proteomics: Plasma was isolated from EDTA-collected\n blood within 4hrs of collection centrifuging tubes at 500 x g for 10\n minutes at room temperature (RT). Plasma was transferred into fresh\n conical tubes and centrifuged again (500 x g, 10 minutes, RT) before\n aliquoting into 500 µL cryovials and transferred to -80°C for long-term\n storage. \u003cbr\u003ePlasma protein levels were quantified using Olink\n multiplex proximity extension assay (PEA) panels (Olink Proteomics; www.olink.com)\n according to the manufacturer’s instructions. Plasma was treated with 1%\n Triton X-100 for 2 hours at room temperature to inactivate any potential\n virus, before shipping to Olink Proteomics. \u003cbr\u003eThe raw expression\n values obtained with the Olink assay are provided in the arbitrary unit\n Normalized Protein Expression (NPX), where high NPX values represent high\n protein concentration. Values were log2-transformed to account for\n heteroskedasticity. Proteins close to the limit of detection are flagged\n in the raw data.","descriptionType":"Methods"},{"description":"The data files contain:\u003cbr\u003e- FCS files of mass cytometry\n measurements\u003cbr\u003e- PatientCharacteristics: file containing clinical\n information regarding the patients. Column \"Cohort\" indicates\n which samples were used for training and which for validation.\u003cbr\u003e-\n Penalization matrix: penalization matrix used to penalize the mass\n cytometry data\u003cbr\u003e- Olink_NPXvalues: data from the Olink plasma\n proteomic assay. Proteomic values are provided in the arbitrary unit\n NPX\u003cbr\u003e- CyTOF_FrequencySignaling_preprocessed: Frequencies and\n processed phosphosignaling responses of the mass cytometry\n dataset\u003cbr\u003e- Correlation_matrix: Absolute spearman correlation\n coefficients of the chord diagram depicted in Figure 3D.\n Further information and requests for resources and\n reagents should be directed to an will be fulfilled by the lead contact,\n Brice Gaudillière (gbrice@stanford.edu)","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Bill \u0026 Melinda Gates Foundation","awardNumber":"COVID-19 Pilot Award OPP1113682","funderIdentifier":"https://ror.org/0456r8d26","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Bill \u0026 Melinda Gates Foundation","awardNumber":"INV-002704","funderIdentifier":"https://ror.org/0456r8d26","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Bill \u0026 Melinda Gates Foundation","awardNumber":"OPP1113682","funderIdentifier":"https://ror.org/0456r8d26","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Bill \u0026 Melinda Gates Foundation","awardNumber":"Pilot Seed Grant","funderIdentifier":"https://ror.org/0456r8d26","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Burroughs Wellcome Fund","funderIdentifier":"https://ror.org/01d35cw23","funderIdentifierType":"ROR"},{"funderName":"CEND*","awardNumber":"CEND Covid Catalyst Award"},{"schemeUri":"https://ror.org","funderName":"Centers for Disease Control and Prevention","awardNumber":"75D30120C08009","funderIdentifier":"https://ror.org/042twtr12","funderIdentifierType":"ROR"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"Center for Health System Innovation, University of Southern California","awardNumber":"Pilot Seed Grant","funderIdentifier":"https://doi.org/10.13039/100012685","funderIdentifierType":"Crossref Funder ID"},{"schemeUri":"https://ror.org","funderName":"Consejo Nacional de Humanidades, Ciencias y Tecnologías","awardNumber":"289788","funderIdentifier":"https://ror.org/059ex5q34","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Consejo Nacional de Humanidades, Ciencias y Tecnologías","awardNumber":"311783","funderIdentifier":"https://ror.org/059ex5q34","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Doris Duke Charitable Foundation","awardNumber":"2018100A","funderIdentifier":"https://ror.org/04n65rp89","funderIdentifierType":"ROR"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"Mercatus Center, George Mason University","awardNumber":"Fast Grants for COVID-19","funderIdentifier":"https://doi.org/10.13039/100019004","funderIdentifierType":"Crossref Funder ID"},{"schemeUri":"https://ror.org","funderName":"Instituto Nacional do Câncer","awardNumber":"Task Order No. HHSN261100039","funderIdentifier":"https://ror.org/055n68305","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Instituto Nacional do Câncer","awardNumber":"Contract No. HHSN261201500003I","funderIdentifier":"https://ror.org/055n68305","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institute of Allergy and Infectious Diseases","awardNumber":"K23 grant AI135037","funderIdentifier":"https://ror.org/043z4tv69","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institute of Allergy and Infectious Diseases","awardNumber":"5U19AI100627-09 Systems Approach to Immunity and Inflammation COVID supplement","funderIdentifier":"https://ror.org/043z4tv69","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institute of Allergy and Infectious Diseases","awardNumber":"CCHI U19AI057229","funderIdentifier":"https://ror.org/043z4tv69","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institute of General Medical Sciences","awardNumber":"R35GM137936","funderIdentifier":"https://ror.org/04q48ey07","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institute of General Medical Sciences","awardNumber":"R35GM138353","funderIdentifier":"https://ror.org/04q48ey07","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Cancer Institute","awardNumber":"SeroNet 1U54CA260517","funderIdentifier":"https://ror.org/040gcmg81","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institute of General Medical Sciences","awardNumber":"T32GM089626","funderIdentifier":"https://ror.org/04q48ey07","funderIdentifierType":"ROR"},{"funderName":"Rachford and Carlota A. Harris Endowed Professorship*"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"Sean N. Parker Center for Allergy and Asthma Research, Stanford University","funderIdentifier":"https://doi.org/10.13039/100016667","funderIdentifierType":"Crossref Funder ID"},{"schemeUri":"https://ror.org","funderName":"Parker Institute for Cancer Immunotherapy","funderIdentifier":"https://ror.org/0184qbg02","funderIdentifierType":"ROR"},{"funderName":"Sunshine Foundation*"},{"schemeUri":"https://ror.org","funderName":"United States Food and Drug Administration","awardNumber":"75F40120C00176","funderIdentifier":"https://ror.org/034xvzb47","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"United States Food and Drug Administration","awardNumber":"HHSF223201610018C","funderIdentifier":"https://ror.org/034xvzb47","funderIdentifierType":"ROR"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"\n        Alfred E. Mann Institute for Biomedical Engineering, University of\n        Southern California\n      ","funderIdentifier":"https://doi.org/10.13039/100013829","funderIdentifierType":"Crossref Funder ID"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Feyaerts, Dorien</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/00f54p054" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University</affiliation>
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    <creator>
      <creatorName nameType="Personal">Hedou, Julien</creatorName>
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    <creator>
      <creatorName nameType="Personal">Gillard, Joshua</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01yb10j39" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Radboud Institute for Molecular Life Sciences</affiliation>
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    <creator>
      <creatorName nameType="Personal">Chen, Han</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Tsai, Eileen S.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Peterson, Laura S.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ando, Kazuo</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Manohar, Monali</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Do, Evan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Dhondalay, Gopal K.R.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Fitzpatrick, Jessica</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Artandi, Maja</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Chang, Iris</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Snow, Theo</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Chinthrajah, R. Sharon</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Warren, Christopher M.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wittman, Richard</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Meyerowitz, Justin G.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Ganio, Edward A.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Stelzer, Ina A.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Han, Xiaoyuan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05ma4gw77" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of the Pacific</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Verdonk, Franck</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Gaudillière, Dyani K.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Mukherjee, Nilanjan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tsai, Amy S.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Rumer, Kristen K.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Jacobsen, Danielle R.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Bjornson-Hooper, Zachary B.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Jiang, Sizun</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Fragoso Saavedra, Sergio</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00xgvev73" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán</affiliation>
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    <creator>
      <creatorName nameType="Personal">Valdés Ferrer, Sergio Iván</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00xgvev73" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán</affiliation>
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    <creator>
      <creatorName nameType="Personal">Kelly, J. Daniel</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01t8svj65" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California San Francisco Medical Center</affiliation>
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    <creator>
      <creatorName nameType="Personal">Furman, David</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Aghaeepour, Nima</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Angst, Martin S.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Boyd, Scott D.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Pinsky, Benjamin A.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Nolan, Garry P.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Nadeau, Kari C.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gaudillière, Brice</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">McIlwain, David R.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Integrated plasma proteomic and single-cell immune signaling network
      signatures demarcate mild, moderate, and severe COVID-19
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2022</publicationYear>
  <subjects>
    <subject>Mass cytometry</subject>
    <subject>SARS-CoV-2</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Proteomics</subject>
    <subject>Olink</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Bill &amp; Melinda Gates Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/0456r8d26</funderIdentifier>
      <awardNumber>COVID-19 Pilot Award OPP1113682</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Bill &amp; Melinda Gates Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/0456r8d26</funderIdentifier>
      <awardNumber>INV-002704</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Bill &amp; Melinda Gates Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/0456r8d26</funderIdentifier>
      <awardNumber>OPP1113682</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Bill &amp; Melinda Gates Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/0456r8d26</funderIdentifier>
      <awardNumber>Pilot Seed Grant</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Burroughs Wellcome Fund</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01d35cw23</funderIdentifier>
    </fundingReference>
    <fundingReference>
      <funderName>CEND*</funderName>
      <awardNumber>CEND Covid Catalyst Award</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Centers for Disease Control and Prevention</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/042twtr12</funderIdentifier>
      <awardNumber>75D30120C08009</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Center for Health System Innovation, University of Southern California</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID" schemeURI="https://www.crossref.org/services/funder-registry/">http://dx.doi.org/10.13039/100012685</funderIdentifier>
      <awardNumber>Pilot Seed Grant</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Consejo Nacional de Humanidades, Ciencias y Tecnologías</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/059ex5q34</funderIdentifier>
      <awardNumber>289788</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Consejo Nacional de Humanidades, Ciencias y Tecnologías</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/059ex5q34</funderIdentifier>
      <awardNumber>311783</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Doris Duke Charitable Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04n65rp89</funderIdentifier>
      <awardNumber>2018100A</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Mercatus Center, George Mason University</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID" schemeURI="https://www.crossref.org/services/funder-registry/">http://dx.doi.org/10.13039/100019004</funderIdentifier>
      <awardNumber>Fast Grants for COVID-19</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Instituto Nacional do Câncer</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/055n68305</funderIdentifier>
      <awardNumber>Task Order No. HHSN261100039</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Instituto Nacional do Câncer</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/055n68305</funderIdentifier>
      <awardNumber>Contract No. HHSN261201500003I</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of Allergy and Infectious Diseases</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/043z4tv69</funderIdentifier>
      <awardNumber>K23 grant AI135037</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of Allergy and Infectious Diseases</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/043z4tv69</funderIdentifier>
      <awardNumber>5U19AI100627-09 Systems Approach to Immunity and Inflammation COVID supplement</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of Allergy and Infectious Diseases</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/043z4tv69</funderIdentifier>
      <awardNumber>CCHI U19AI057229</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of General Medical Sciences</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04q48ey07</funderIdentifier>
      <awardNumber>R35GM137936</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of General Medical Sciences</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04q48ey07</funderIdentifier>
      <awardNumber>R35GM138353</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Cancer Institute</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/040gcmg81</funderIdentifier>
      <awardNumber>SeroNet 1U54CA260517</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of General Medical Sciences</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04q48ey07</funderIdentifier>
      <awardNumber>T32GM089626</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Rachford and Carlota A. Harris Endowed Professorship*</funderName>
    </fundingReference>
    <fundingReference>
      <funderName>Sean N. Parker Center for Allergy and Asthma Research, Stanford University</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID" schemeURI="https://www.crossref.org/services/funder-registry/">http://dx.doi.org/10.13039/100016667</funderIdentifier>
    </fundingReference>
    <fundingReference>
      <funderName>Parker Institute for Cancer Immunotherapy</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/0184qbg02</funderIdentifier>
    </fundingReference>
    <fundingReference>
      <funderName>Sunshine Foundation*</funderName>
    </fundingReference>
    <fundingReference>
      <funderName>United States Food and Drug Administration</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/034xvzb47</funderIdentifier>
      <awardNumber>75F40120C00176</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>United States Food and Drug Administration</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/034xvzb47</funderIdentifier>
      <awardNumber>HHSF223201610018C</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>
        Alfred E. Mann Institute for Biomedical Engineering, University of
        Southern California
      </funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID" schemeURI="https://www.crossref.org/services/funder-registry/">http://dx.doi.org/10.13039/100013829</funderIdentifier>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Submitted">2022-06-01T19:44:06Z</date>
    <date dateType="Issued">2022-09-02T00:00:00Z</date>
    <date dateType="Available">2022-09-02T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1101/2021.02.09.430269</relatedIdentifier>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1016/j.xcrm.2022.100680</relatedIdentifier>
  </relatedIdentifiers>
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    <size>17381263372 bytes</size>
  </sizes>
  <version>6</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      The biological determinants underlying the range of COVID-19 clinical
      manifestations are not fully understood. Here, over 1400 plasma proteins
      and 2600 single-cell immune features comprising cell phenotype, endogenous
      signaling activity, and signaling responses to inflammatory ligands are
      cross-sectionally assessed in peripheral blood from 97 patients with mild,
      moderate, and severe COVID-19 and 40 uninfected patients. Using an
      integrated computational approach to analyze the combined plasma and
      single-cell proteomic data, we identify and independently validate a
      multivariate model classifying COVID-19 severity (multi-class
      AUCtraining&amp;nbsp;= 0.799, p-value = 4.2e-6; multi-class
      AUCvalidation&amp;nbsp;= 0.773, p-value = 7.7e-6). Examination of
      informative model features reveals novel biological signatures of COVID-19
      severity, including the dysregulation of JAK/STAT, MAPK/mTOR, and NF-κB
      immune signaling networks in addition to recapitulating known hallmarks of
      COVID-19. These results provide a set of early determinants of COVID-19
      severity that may point to therapeutic targets for prevention and/or
      treatment of COVID-19 progression.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Mass cytometry:&lt;/p&gt; &lt;p&gt;Blood was collected in EDTA
      tubes. Anticoagulated blood was processed into peripheral blood
      mononuclear cells (PBMC) by density gradient centrifugation using
      published methods (Syed et al., 2014). PBMC were stored in 10% DMSO and
      frozen in liquid nitrogen until thawing and
      staining. &lt;br&gt;Cryopreserved PBMC were quickly thawed, washed two
      times with supplemented medium, and rested for 1h at 37°C in RPMI 1640
      medium supplemented with 10% fetal bovine serum, 1%
      Penicillin-Streptomycin, and 1% L-Glutamine. PBMC were counted and checked
      for viability. 0.5-1x10&lt;sup&gt;6&lt;/sup&gt; cells were either
      stimulated with lipopolysaccharide (LPS; 1?g/ml) and CL097 (TLR7/8
      agonist; 1?g/ml), interleukin-2 (IL-2), IL-4, IL-6 and interferon-? (IFN?;
      all 100 ng/ml), a cocktail of phorbol 12-myristate 13-acetate (PMA),
      ionomycin, brefeldin A and monensin (1x; PI cocktail), or left
      unstimulated for 15 minutes at 37°C. After stimulation, samples were fixed
      with Proteomic Stabilizer (SmartTube) and stored at -80°C until further
      processing for mass cytometry analysis. &lt;/p&gt; &lt;p&gt;Plasma
      proteomics:&lt;/p&gt; &lt;p&gt;Plasma was isolated from EDTA-collected
      blood within 4hrs of collection centrifuging tubes at 500 x g for 10
      minutes at room temperature (RT). Plasma was transferred into fresh
      conical tubes and centrifuged again (500 x g, 10 minutes, RT) before
      aliquoting into 500 µL cryovials and transferred to -80°C for long-term
      storage. &lt;br&gt;Plasma protein levels were quantified using Olink
      multiplex proximity extension assay (PEA) panels (Olink Proteomics; &lt;a
      href="http://www.olink.com/"&gt;www.olink.com&lt;/a&gt;)
      according to the manufacturer’s instructions. Plasma was treated with 1%
      Triton X-100 for 2 hours at room temperature to inactivate any potential
      virus, before shipping to Olink Proteomics. &lt;br&gt;The raw expression
      values obtained with the Olink assay are provided in the arbitrary unit
      Normalized Protein Expression (NPX), where high NPX values represent high
      protein concentration. Values were log2-transformed to account for
      heteroskedasticity. Proteins close to the limit of detection are flagged
      in the raw data.&lt;/p&gt;
    </description>
    <description descriptionType="Other">
      &lt;p&gt;The data files contain:&lt;br&gt;- FCS files of mass cytometry
      measurements&lt;br&gt;- PatientCharacteristics: file containing clinical
      information regarding the patients. Column "Cohort" indicates
      which samples were used for training and which for validation.&lt;br&gt;-
      Penalization matrix: penalization matrix used to penalize the mass
      cytometry data&lt;br&gt;- Olink_NPXvalues: data from the Olink plasma
      proteomic assay. Proteomic values are provided in the arbitrary unit
      NPX&lt;br&gt;- CyTOF_FrequencySignaling_preprocessed: Frequencies and
      processed phosphosignaling responses of the mass cytometry
      dataset&lt;br&gt;- Correlation_matrix: Absolute spearman correlation
      coefficients of the chord diagram depicted in Figure 3D.&lt;/p&gt;
      &lt;p&gt;&lt;span style="font-size:11pt;font-family:Arial ,
      sans-serif;"&gt;Further information and requests for resources and
      reagents should be directed to an will be fulfilled by the lead contact,
      Brice Gaudillière (&lt;/span&gt;&lt;span
      style="font-size:12pt;font-family:'Times New Roman' ,
      serif;"&gt;&lt;a style="color:#954f72;"
      href="mailto:gbrice@stanford.edu"&gt;&lt;span
      style="font-size:11pt;font-family:Arial ,
      sans-serif;"&gt;gbrice@stanford.edu)&lt;/span&gt;&lt;/a&gt;&lt;/span&gt;&lt;/p&gt;
    </description>
  </descriptions>
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