{"data":{"id":"10.5061/dryad.905qftv1c","type":"dois","attributes":{"doi":"10.5061/dryad.905qftv1c","prefix":"10.5061","suffix":"dryad.905qftv1c","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Lanier, Olivia","nameType":"Personal","affiliation":["University of New Mexico"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6401-0465","nameIdentifierScheme":"ORCID"}]},{"name":"Morse, Brinkley","nameType":"Personal","affiliation":["The University of Texas at Austin"],"nameIdentifiers":[]},{"name":"Cisneros, Ethan","nameType":"Personal","affiliation":["The University of Texas at Austin"],"nameIdentifiers":[]},{"name":"Chapa Villarreal, Fabiola","nameType":"Personal","affiliation":["The University of Texas at Austin"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2531-7584","nameIdentifierScheme":"ORCID"}]},{"name":"Maestas-Olguin, Angelea","nameType":"Personal","affiliation":["University of New Mexico"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6102-7934","nameIdentifierScheme":"ORCID"}]},{"name":"Al Buzz, Reem","nameType":"Personal","affiliation":["The University of Texas at Austin"],"nameIdentifiers":[]},{"name":"Savk, Ani","nameType":"Personal","affiliation":["The University of Texas at Austin"],"nameIdentifiers":[]},{"name":"Peppas, Nicholas","nameType":"Personal","affiliation":["The University of Texas at Austin"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0894-5626","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Surface chemistry governs sex-dependent responses to PEG and zwitterionic NPs"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Nano-technology","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"Gene therapy","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Precision medicine","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Nanomedicine","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[{"name":"Lanier, Olivia","nameType":"Personal","affiliation":["University of New Mexico"],"contributorType":"ContactPerson","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6401-0465","nameIdentifierScheme":"ORCID"}]},{"name":"Morse, Brinkley","nameType":"Personal","affiliation":["The University of Texas at Austin"],"contributorType":"ContactPerson","nameIdentifiers":[]},{"name":"Cisneros, Ethan","nameType":"Personal","affiliation":["The University of Texas at Austin"],"contributorType":"ContactPerson","nameIdentifiers":[]},{"name":"Chapa Villarreal, Fabiola","nameType":"Personal","affiliation":["The University of Texas at Austin"],"contributorType":"ContactPerson","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2531-7584","nameIdentifierScheme":"ORCID"}]},{"name":"Maestas-Olguin, Angelea","nameType":"Personal","affiliation":["University of New Mexico"],"contributorType":"ContactPerson","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6102-7934","nameIdentifierScheme":"ORCID"}]},{"name":"Savk, Ani","nameType":"Personal","affiliation":["The University of Texas at Austin"],"contributorType":"ContactPerson","nameIdentifiers":[]},{"name":"Peppas, Nicholas","nameType":"Personal","affiliation":["The University of Texas at Austin"],"contributorType":"ContactPerson","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0894-5626","nameIdentifierScheme":"ORCID"}]}],"dates":[{"date":"2026-04-21T05:09:27Z","dateType":"Created"},{"date":"2026-07-12T00:23:06Z","dateType":"Submitted"},{"date":"2026-07-28T00:00:00Z","dateType":"Issued"},{"date":"2026-07-28T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1126/sciadv.aef4315","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["53115 bytes"],"formats":[],"version":"7","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Nanoparticle carriers are widely used for nucleic acid delivery, yet the\n dominant surface modifier poly(ethylene glycol) (PEG) increasingly raises\n concerns due to immunogenicity. Zwitterionic polymers are emerging as\n promising PEG alternatives, but their performance is rarely evaluated in\n primary immune cells or across biological sexes. Here, we synthesized\n pH-responsive PEG- and zwitterion-grafted cationic nanoparticles,\n including PEG methyl ether methacrylate (PEGMMA), carboxybetaine\n methacrylate (CBMA), sulfobetaine DMAPS, and polymeric PDMAPS, and\n assessed their cytotoxicity and siRNA delivery in primary male and female\n murine macrophages. All formulations enabled intracellular siRNA uptake\n and suppressed tumor necrosis factor–α (TNF-α) expression. However,\n sex-dependent effects varied by surface chemistry and biological endpoint:\n zwitterionic nanoparticles exhibited sex-specific effects in cytotoxicity\n and gene silencing despite similar uptake, whereas PEGMMA showed higher\n uptake in females but comparable knockdown across sexes. These findings\n demonstrate that uptake alone does not predict functional efficacy and\n highlight the importance of sex-informed evaluation when developing\n nanomedicines.","descriptionType":"Abstract"},{"description":"\u003cem\u003e\u003cstrong\u003eMaterials:\u003c/strong\u003e\u003c/em\u003e Monomers 2-(dimethylamino)ethyl methacrylate (DMAEMA) (Cat. No. 234907), bis(2-methacryloyl)oxyethyl disulfide (DSDMA), Poly(ethylene glycol) methyl ether methacrylate solution (PEGMMA2k, Mn = 2000) (Cat. No. 457876), ethyl α-bromoisobutyrate (EBiB, 98%) (Cat. No. 252271), and L-ascorbic acid (AA) (Cat. No. A7506) were purchased from Sigma-Aldrich. Hexyl methacrylate (Cat. No. M0503) and Tris(2-pyridylmethyl)amine (Cat. No. T2671) were purchased from TCI America. Brij 30 (Cat. Code 216725000), Brij 35 (Cat. No. 228345000), and copper (II) bromide (99 + %) (Cat. No. 206331000) were purchased from Acros Organics. Tetrahydrofuran, acetone, ethanol, and hydrochloric acid were purchased from Fisher Scientific. Carboxybetaine methacrylate (CBMA) was purchased from MedChem Express. 2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA),  4-((((2-Carboxyethyl)thio) carbono thioyl) thio)-4-cyanopentanoic acid (CTA), 4,4-azobis(4-cyanopentanoic acid) (ACVA), and sodium chloride (NaCl) were used as received from Sigma Aldrich and Fisher Scientific. RPMI 1640 media, penicillin-streptomycin, and fetal bovine serum (FBS), lipopolysaccharide (LPS), and macrophage colony-stimulating factor (MCSF) were all purchased from Fisher Scientific. MTS reagents (CellTiter 96 AQueous One Solution Cell Proliferation Assay) were obtained from Promega Corporation. Mission siRNA Fluorescent Universal Negative Control #2, 6-FAM (catalog #SIC008-5X1NMOL) was purchased from Sigma Aldrich. Mouse TNF-ɑ siRNA was purchased from Thermo Scientific (catalog #4390771), and the Mouse TNF-ɑ/TNFA/TNFSF2 ELISA Pair Set was sourced from Sino Biological (catalog #SEK50349-5). \u003cstrong\u003eTable 1: Reagents Required for Nanocarrier Synthesis\u003c/strong\u003e \u003cstrong\u003eCompound Name\u003c/strong\u003e \u003cstrong\u003eRole in Synthesis\u003c/strong\u003e \u003cstrong\u003eIUPAC/Chemical Name\u003c/strong\u003e \u003cstrong\u003eChemical Structure\u003c/strong\u003e Copper(II) Bromide Initiator \u003cbr\u003e CuBr₂ Tris(2-pyridylmethyl)amine (TPMA) Ligand Tris[2-(pyridylmethyl)]amine \u003cbr\u003e Brij-30 Surfactant Polyoxyethylene(4) lauryl ether \u003cbr\u003e Brij-35 Surfactant Polyoxyethylene(23) lauryl ether \u003cbr\u003e Hexyl methacrylate (HMA) Hydrophobic Co-monomer 2-methyl-2-propenoic acid hexyl ester \u003cbr\u003e Poly(ethylene glycol) methyl ether methacrylate (PEGMMA) Hydrophilic Graft (PEG-NP) Methacrylic acid, 2-[methoxy(polyethyleneoxy)propyl] ester \u003cbr\u003e Carboxybetaine methacrylate (CBMA) Zwitterionic Graft 2-[(methacryloyloxy)ethyl]dimethylammonio]acetate \u003cbr\u003e Sulfobetaine methacrylate (SBMA) Zwitterionic Graft [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide \u003cbr\u003e Polymeric SBMA Zwitterionic Graft Polymer Poly-[2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide \u003cbr\u003e Bis(2-methacryloyloxyethyl) disulfide Crosslinking Agent Disulfide-based dimethacrylate \u003cbr\u003e 2-(Dimethylamino)ethyl methacrylate (DMAEMA) Cationic Co-monomer Dimethylaminoethyl methacrylate \u003cbr\u003e Ascorbic Acid Reducing Agent \u003cbr\u003e C₆H₈O₆ Water Solvent \u003cbr\u003e H₂O \u003cem\u003e\u003cstrong\u003eSynthesis via RAFT Polymerization:\u003c/strong\u003e\u003c/em\u003e The synthesis of PSBMA was carried out by RAFT polymerization using a method previously described with slight modifications. To obtain a similar molecular weight to what was used for the PEG NPs, the ratio between SBMA and the CTA was carefully tailored. SBMA (1396.75 mg, 5 mmol, 7 equiv.), CTA (219.58 mg, 0.71 mmol, 1 equiv.), and ACVA (40 mg, 0.14 mmol, 0.2 equiv.) were dissolved in a 0.5 M NaCl solution (50% wt. with SBMA). The pH was adjusted to 7, and the solution was purged with nitrogen for 40 min. The solution was then left to polymerize at 70°C for 19h. Finally, after the reaction was finished, the polymer was lyophilized and stored until further use. \u003cem\u003e\u003cstrong\u003eSynthesis of Cationic Nanoparticles via ARGET-ATRP:\u003c/strong\u003e\u003c/em\u003e PEGMMA, CBMA, SBMA, and PSBMA NPs were synthesized using a one-pot oil-in-water emulsion polymerization approach via ARGET-ATRP process. Emulsions were created by mixing all reagents in a 1-dram glass vial in 2-mL batches and homogenizing them for 20 minutes with a 24-tip microtip sonicator probe (10s on/10s off cycle) (Sonicator Ultrasonic Processor XL from QSonica). Subsequently, the samples were transferred into an MBraun Glovebox LABmaster 130 under inert nitrogen conditions (O\u003csub\u003e2\u003c/sub\u003e\u0026lt;0.1 ppm; H\u003csub\u003e2\u003c/sub\u003eO \u0026lt;0.1 ppm) to initiate the reaction by adding ascorbic acid. After 24 hours, the reaction was stopped by exposing the samples to air and diluting them to a 0.5 N concentration by adding 4N HCl. Unreacted monomers and impurities were removed from the NPs using ionomer collapse, which involves acidifying the samples and precipitating them with a low dielectric constant solvent like tetrahydrofuran. The nanogels were precipitated through ionomer collapse three times and collected after each cycle by centrifugation at 4000g for 5 minutes. Following the final centrifugation, the NPs were resuspended in 5 mL of deionized water and dialyzed against deionized water for at least 7 days to eliminate any residual tetrahydrofuran \u003csup\u003e38\u003c/sup\u003e. CBMA and SBMA particles were synthesized at two different monomer input volumes to investigate the effect of zwitterionic concentration. CBMA and SBMA were synthesized using 11 μL and 13 μL of 2 mg/mL zwitterionic stock solutions, respectively. \u003cem\u003e\u003cstrong\u003eNuclear Magnetic Resonance:\u003c/strong\u003e\u003c/em\u003e The \u003csup\u003e1\u003c/sup\u003eH^^ Nuclear Magnetic Resonance (NMR) spectrum of PSBMA was obtained using a Bruker 500 MHz NMR spectrometer. PSBMA was dissolved in D\u003csub\u003e2\u003c/sub\u003eO at a 5 mg/mL concentration and analyzed using the MestReNova 14.3.0 software. \u003cem\u003e\u003cstrong\u003eFourier-Transformed Infrared Spectroscopy:\u003c/strong\u003e\u003c/em\u003e The Fourier-Transformed Infrared (FTIR) Spectroscopy spectrum of PSBMA was acquired using an Attenuated Total Reflectance FTIR through a germanium crystal on a Nicolet iS10 spectrometer with a SMART iTX accessory, both from Thermo Scientific. The lyophilized sample was analyzed by placing it on the crystal after the background spectrum was collected. The spectrum was analyzed using Omnic software. \u003cem\u003e\u003cstrong\u003eCharacterizing Nanoparticle Size \u0026amp; Electrophoretic Potential:\u003c/strong\u003e\u003c/em\u003e The hydrodynamic diameters and zeta potentials of the NPs were determined using dynamic light scattering (DLS) and zeta potential measurements on a Malvern ZetaSizer (NanoZS). For DLS characterization, the stock NPs solution was diluted 66.67 times in 1X PBS (75 μL NP: 5 mL PBS) to a final volume of 5 mL. Measurements were taken at pH 3-5 (acidic), pH 6-7 (neutral), and pH 9 (basic) to assess NPs size and monodispersity (expressed as the polydispersity index, PDI). The volume swelling ratio was calculated by: where \u003cem\u003eV\u003c/em\u003e is the respective volume at each pH, which simplifies to each diameter (\u003cem\u003ed\u003c/em\u003e) at each pH cubed. Zeta potential measurements were performed on diluted NPs (150 μL NP: 6 mL 5 mM sodium phosphate buffer) at pH 3-5 (acidic) and pH 6-7 (neutral). Folded capillary zeta cells were used for these measurements. All DLS and zeta potential readings were conducted in triplicate using standardized protocols optimized for cationic NPs. \u003cem\u003e\u003cstrong\u003eMonocyte Isolation \u0026amp; Culture:\u003c/strong\u003e\u003c/em\u003e Bone marrow-derived monocytes were isolated from the hindlimbs of male and female FVBn mice (all littermates, 6-8 weeks old; N=3 per sex) and cultured as described by Rybalko et al. Bones from the hindlimbs of the mice were extracted, and marrow was subsequently isolated in the cell culture hood by flushing bones with sterile PBS. Cells were centrifuged at 500g for 5 min and resuspended in RPMI-1640 supplemented with 10% FBS and 1% penicillin–streptomycin, along with MCSF (10 ng/mL) at a density of 1 × 10⁶ cells/mL. For 96-well plates, 100 μl of cells (1 × 10\u003csup\u003e6\u003c/sup\u003e cells/ml) were added to each well. Media with fresh MCSF was added on days 3, 5, and 7 to differentiate monocytes into macrophages. Experiments were performed beginning on day 7. All experiments (cytotoxicity, uptake, and TNF-α knockdown) included N = 3 biological replicates per sex, with n = 6–9 technical replicates per condition. Samples were not pooled; each biological replicate corresponds to cells derived from a single mouse. The same batch of cells from each animal was used across all assays to ensure consistency between endpoints. \u003cem\u003e\u003cstrong\u003eCytotoxicity:\u003c/strong\u003e\u003c/em\u003e The cytotoxicity of the NPs was assessed using the colorimetric CellTiter 96 AQueous One Solution Cell Proliferation Assay kit. This kit uses a soluble tetrazolium salt, [3-[4,5-dimethylthiazol-2-yl]-5-(3-carboxymethyl phenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS), which is bio-reduced by viable cells into a purple formazan product. The level of MTS bio-reduction correlates with the metabolism of the cells, which is often used as a measure of cell viability. NPs were tested on primary murine monocytes grown to 40,000 cells per well. On day 7, NPs were added to the cell culture medium at concentrations of 12.5, 50, 125, and 500 μg/ml. After 24 hours of NP exposure, the cells were washed twice with DPBS and resuspended in assay media (16.67% MTS reagent, 83.33% growth media without phenol red). The plates were incubated for 2 hours at 37°C and 5% CO\u003csub\u003e2\u003c/sub\u003e, after which absorbance readings were taken at 490 using a Biotek Cytation 3 Plate Reader. \u003cem\u003e\u003cstrong\u003eFluorescent siRNA Loading and Uptake in Primary Monocytes:\u003c/strong\u003e\u003c/em\u003e NPs (5000 ng/ml) were loaded at a 10:1 NP: siRNA ratio with 500 ng/ml fluorescent siRNA (fluorescent siRNA or anti-TNF-ɑ siRNA) in sterile 1% DEPC-treated PBS at pH 5.5, vortexed, and allowed to incubate for one hour in the dark. Loaded NPs were centrifuged at 15,000 x g for 10 min, and the loading supernatant was removed and replaced with 500 μL of cell culture medium. Loaded NPs solutions were then added to the cells at 12.5 μg/ml for 24 hours. Wells were then washed twice with DPBS and placed in phenol-free RPMI 1640 culture medium. Wells were imaged using an Incucyte S3 Live Cell Analysis Instrument (Sartorius). The phase contrast and green fluorescent channels were used to measure the cells and siRNA, respectively, with three wells per condition. The Incucyte software was used to measure cell confluency and fluorescence intensity within the cells. Relative uptake was then calculated via:  (Fluorescence Intensity per Area)/(Cell Confluency)=Relative Uptake  A control condition using NPs without fluorescent siRNA (blank NPs) was included to account for background fluorescence. The average signal from this control was subtracted from all uptake values. \u003cem\u003e\u003cstrong\u003eTNF-ɑ Knockdown:\u003c/strong\u003e\u003c/em\u003e NPs loaded with anti-TNF-ɑ siRNA were centrifuged at 15,000g for 10 min, and the loading supernatant was removed and replaced with 500 μL of cell culture medium. Simultaneously, mouse macrophages were cultured as previously described and were treated with LPS at 50 ng/ml overnight to induce TNF-ɑ production. Macrophages were then treated with NPs at 12.5 μg/ml. After 24 hours, the treated cell media was collected. TNF-ɑ content was assessed with an enzyme-linked immunosorbent assay kit manufactured by Sino Biological. The standard curve was plotted using a 4-parameter logistic curve. Percent TNF-ɑ knockdown was calculated by normalizing to the LPS-stimulated control of the specified sex. \u003cem\u003e\u003cstrong\u003eStatistical Analyses:\u003c/strong\u003e\u003c/em\u003e All experiments were run in triplicate. Primary cell experiments were done with biological triplicates (n=3) for each sex (male, female), with technical replicates for each assay ranging from 3-6. For technical replicates, the mean values were found. Values are reported as the biological mean ± standard deviation unless otherwise noted in the figure caption. Data were plotted in Microsoft Excel and GraphPad Prism. All statistics were run in GraphPad Prism as t-tests, one-way ANOVA, or two-way ANOVA (sex + nanoparticle treatment considered multiple variables) with a post-hoc analysis using Tukey HSD or Šidák’s. Reported significant results are p \u0026lt; 0.05 unless otherwise stated.","descriptionType":"Methods"},{"description":"# Surface chemistry governs sex-dependent responses to PEG and\n zwitterionic NPs Dataset DOI:\n [10.5061/dryad.905qftv1c](https://doi.org/10.5061/dryad.905qftv1c) ##\n Description of the data and file structure We have submitted our raw data\n for nanoparticle size and PDI acquired from dynamic light scattering\n (Data_SizeandPDI.csv), metabolic activity assays\n (Cytotoxicity_Zwitterion.csv), nanoparticle cell uptake via Incucyte\n (NPUptake_Zwitterion.csv), and TNF-alpha knockdown via ELISA\n (TNFELISA_Zwitterion.csv). Dataset DOI:\n [10.5061/dryad.905qftv1c](https://doi.org/10.5061/dryad.905qftv1c) ###\n Files and variables #### File: Cytotoxicty_Zwitterion.xlsx\n **Description:** This dataset provides raw data from our cell metabolic\n activity assay. The cytotoxicity of the nanoparticles was assessed using\n the colorimetric CellTiter 96 AQueous One Solution Cell Proliferation\n Assay kit. This kit uses a soluble tetrazolium salt,\n [3-[4,5-dimethylthiazol-2-yl]-5-(3-carboxymethyl\n phenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS), which is bio-reduced by\n viable cells into a purple formazan product. The level of MTS\n bio-reduction correlates with the metabolism of the cells, which is often\n used as a measure of cell viability. NPs were tested on primary murine\n monocytes grown to 40,000 cells per well. On day 7, NPs were added to the\n cell culture medium at concentrations of 12.5, 50, 125, and 500 μg/ml.\n After 24 hours of NP exposure, the cells were washed twice with DPBS and\n resuspended in assay media (16.67% MTS reagent, 83.33% growth media\n without phenol red). The plates were incubated for 2 hours at 37°C and 5%\n CO~2~, after which absorbance readings were taken at 490 using a Biotek\n Cytation 3 Plate Reader. This dataset shows the raw absorbance readings.\n We then converted the absorbance values to relative metabolic activity\n compared to the untreated control for each corresponding animal. #####\n Variables * *Sample*: This indicates sample information on nanoparticle\n population PEGMMA, SBMA, CBMA, or PSBMA, or the control. The control here\n indicates cells that were untreated and left to grow in media only. *\n *Animal*: This indicates which biological replicate the cells were from.\n We had three females and three males indicated as Female 1, Female 2,\n Female 3, Male 1, Male 2, and Male 3. * *Concentration*: This is the\n concentration of nanoparticles added to each well with cells. *\n *Absorbance 1*: The first technical replicate for absorbance. *\n *Absorbance 2*: The second technical replicate for absorbance. *\n *Absorbance 3*: The third technical replicate for absorbance. #### File:\n Data_SizeandPDI.xlsx **Description:** This dataset provides raw dynamic\n light scattering (DLS) data for size and PDI of nanoparticles used in our\n study. The temperature was set to 25°C for all measurements and the DLS\n measurements were performed at a 173° angle. ##### Variables * *Sample\n Name*: This gives information on which nanoparticle population is being\n measured from our paper, including PEGMMA, SBMA, CBMA, and PSBMA\n nanoparticle formulations. It also tells at which pH the measurement was\n run. Measurements of the nanoparticles were done at pH 3-5, pH 6-7, and pH\n 9. * *Z-Average*: This is the average hydrodynamic diameter given by the\n equipment in nm for the nanoparticles. * *PdI*: This is the polydispersity\n index of the nanoparticle formulation, which describes how monodisperse\n the sample is. * *Mean count rate*: This is a parameter from the DLS\n equipment that shows the count of particles it is getting in kcps. This is\n associated with the size and PDI measurements. * *ZP*: This is the zeta\n potential in mV of the nanoparticles. NA indicates not applicable as zeta\n potential measurements were only taken 3 times, and were not run at pH\n 9.          #### File: NPUptake_Zwitterion.xlsx **Description:** This\n dataset was run using the Incucyte. NPs (5000 ng/ml) were loaded at a 10:1\n NP: siRNA ratio with 500 ng/ml fluorescent siRNA (fluorescent siRNA or\n anti-TNF-ɑ siRNA) in sterile 1% DEPC-treated PBS at pH 5.5, vortexed, and\n allowed to incubate for one hour in the dark. Loaded NPs were centrifuged\n at 15,000 x g for 10 min, and the loading supernatant was removed and\n replaced with 500 μL of cell culture medium. Loaded NPs solutions were\n then added to the cells at 12.5 μg/ml for 24 hours. Wells were then washed\n twice with DPBS and placed in phenol-free RPMI 1640 culture medium. Wells\n were imaged using an Incucyte S3 Live Cell Analysis Instrument\n (Sartorius). The phase contrast and green fluorescent channels were used\n to measure the cells and siRNA, respectively, with three wells per\n condition. This is the raw data from the Incucyte indicating siRNA\n integrated intensity object which was a fluorescent measurement done by\n the Incucyte divided by cell area confluence which was taken via phase\n contrast in the Incucyte. A control condition using NPs without\n fluorescent siRNA (blank NPs) was included to account for background\n fluorescence. The average signal from this control was subtracted from all\n uptake values for the corresponding animal. ##### Variables * *Sample*:\n This indicates sample information on nanoparticle population PEGMMA, SBMA,\n CBMA, or PSBMA loaded with fluorescent siRNA, or the control. A control\n condition using NPs without fluorescent siRNA (blank NPs) was included to\n account for background fluorescence. * *Animal*: This indicates which\n biological replicate the cells were from. We had three females and three\n males indicated as Female 1, Female 2, Female 3, Male 1, Male 2, and Male\n 3. * *siRNA Integrated Intensity Object/Cell Area Confluence*: The\n fluorescent signal of each sample calculated by the Incucyte with the\n green fluorescent channel, divided by the cell area confluence calculated\n by the Incucyte based on surface coverage of the cells in the surface\n contract images. #### File: TNFELISA_Zwitterion.xlsx\n **Description:** Nanoparticles loaded with anti-TNF-ɑ siRNA were\n centrifuged at 15,000g for 10 min, and the loading supernatant was removed\n and replaced with 500 μL of cell culture medium. Simultaneously, mouse\n macrophages were cultured as previously described and were treated with\n LPS at 50 ng/ml overnight to induce TNF-ɑ production. Macrophages were\n then treated with NPs at 12.5 μg/ml. After 24 hours, the treated cell\n media was collected. TNF-ɑ content was assessed with an enzyme-linked\n immunosorbent assay kit manufactured by Sino Biological. The standard\n curve was plotted using a 4-parameter logistic curve. Percent TNF-ɑ\n knockdown was calculated by normalizing to the LPS-stimulated control of\n the specified sex. This is the raw data for the absorbance values of the\n ELISA. ##### Variables * *Sample*: This indicates sample information on\n nanoparticle population PEGMMA, SBMA, CBMA, or PSBMA loaded with TNF\n siRNA, or the LPS control which was not treated with nanoparticles.\n Additionally, the standard curve is shown (0, 93.75, 187.5, 375, 750,\n 1500, 3000 pg/ml TNF are indicated by the corresponding numbered samples).\n * *Animal*: This indicates which biological replicate the cells were from.\n We had three females and three males indicated as F1, F2, F3, M1, M2, and\n M3. * *Abs1*: The first technical replicate for absorbance. * *Abs 2*: The\n second technical replicate for absorbance. * *Abs3*: The third technical\n replicate for absorbance. ## Code/software CSV files can be opened with\n any compatible software. Data were analyzed using GraphPad Prism and\n Microsoft Excel. ## Access information Other publicly accessible locations\n of the data: * Not applicable Data were derived from the following\n sources: * Not applicable","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"awardUri":"https://reporter.nih.gov/project-details/9773058","awardTitle":"\n        Sensor arrays based on molecularly imprinted polymers for diagnosis of\n        Sjogren's syndrome\n      ","funderName":"National Institute of Biomedical Imaging and Bioengineering","awardNumber":"5R01EB022025-04","funderIdentifier":"https://ror.org/00372qc85","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/11202697","awardTitle":"\n        Redefining Nanomedicine Beyond One-Size-Fits-All: Uncovering Mechanisms\n        of Sex Differences and Female Life Stages in Drug Delivery\n      ","funderName":"National Institute of General Medical Sciences","awardNumber":"1R35GM160475-01","funderIdentifier":"https://ror.org/04q48ey07","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.905QFTV1C</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Lanier, Olivia</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-6401-0465</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/05fs6jp91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of New Mexico</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Morse, Brinkley</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Cisneros, Ethan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Chapa Villarreal, Fabiola</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2531-7584</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Maestas-Olguin, Angelea</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-6102-7934</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/05fs6jp91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of New Mexico</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Al Buzz, Reem</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Savk, Ani</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Peppas, Nicholas</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0894-5626</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Surface chemistry governs sex-dependent responses to PEG and zwitterionic NPs</title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Nano-technology</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Gene therapy</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Precision medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Nanomedicine</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Institute of Biomedical Imaging and Bioengineering</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/00372qc85</funderIdentifier>
      <awardNumber awardURI="https://reporter.nih.gov/project-details/9773058">5R01EB022025-04</awardNumber>
      <awardTitle>
        Sensor arrays based on molecularly imprinted polymers for diagnosis of
        Sjogren's syndrome
      </awardTitle>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of General Medical Sciences</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04q48ey07</funderIdentifier>
      <awardNumber awardURI="https://reporter.nih.gov/project-details/11202697">1R35GM160475-01</awardNumber>
      <awardTitle>
        Redefining Nanomedicine Beyond One-Size-Fits-All: Uncovering Mechanisms
        of Sex Differences and Female Life Stages in Drug Delivery
      </awardTitle>
    </fundingReference>
  </fundingReferences>
  <contributors>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Lanier, Olivia</contributorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-6401-0465</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/05fs6jp91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of New Mexico</affiliation>
    </contributor>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Morse, Brinkley</contributorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </contributor>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Cisneros, Ethan</contributorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </contributor>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Chapa Villarreal, Fabiola</contributorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2531-7584</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </contributor>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Maestas-Olguin, Angelea</contributorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-6102-7934</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/05fs6jp91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of New Mexico</affiliation>
    </contributor>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Savk, Ani</contributorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </contributor>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Peppas, Nicholas</contributorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0894-5626</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Created">2026-04-21T05:09:27Z</date>
    <date dateType="Submitted">2026-07-12T00:23:06Z</date>
    <date dateType="Issued">2026-07-28T00:00:00Z</date>
    <date dateType="Available">2026-07-28T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1126/sciadv.aef4315</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>53115 bytes</size>
  </sizes>
  <version>7</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      Nanoparticle carriers are widely used for nucleic acid delivery, yet the
      dominant surface modifier poly(ethylene glycol) (PEG) increasingly raises
      concerns due to immunogenicity. Zwitterionic polymers are emerging as
      promising PEG alternatives, but their performance is rarely evaluated in
      primary immune cells or across biological sexes. Here, we synthesized
      pH-responsive PEG- and zwitterion-grafted cationic nanoparticles,
      including PEG methyl ether methacrylate (PEGMMA), carboxybetaine
      methacrylate (CBMA), sulfobetaine DMAPS, and polymeric PDMAPS, and
      assessed their cytotoxicity and siRNA delivery in primary male and female
      murine macrophages. All formulations enabled intracellular siRNA uptake
      and suppressed tumor necrosis factor–α (TNF-α) expression. However,
      sex-dependent effects varied by surface chemistry and biological endpoint:
      zwitterionic nanoparticles exhibited sex-specific effects in cytotoxicity
      and gene silencing despite similar uptake, whereas PEGMMA showed higher
      uptake in females but comparable knockdown across sexes. These findings
      demonstrate that uptake alone does not predict functional efficacy and
      highlight the importance of sex-informed evaluation when developing
      nanomedicines.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;&lt;em&gt;&lt;strong&gt;Materials:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;Monomers 2-(dimethylamino)ethyl methacrylate (DMAEMA) (Cat. No. 234907), bis(2-methacryloyl)oxyethyl disulfide (DSDMA), Poly(ethylene glycol) methyl ether methacrylate solution (PEGMMA2k, Mn = 2000) (Cat. No. 457876), ethyl α-bromoisobutyrate (EBiB, 98%) (Cat. No. 252271), and L-ascorbic acid (AA) (Cat. No. A7506) were purchased from Sigma-Aldrich. Hexyl methacrylate (Cat. No. M0503) and Tris(2-pyridylmethyl)amine (Cat. No. T2671) were purchased from TCI America. Brij 30 (Cat. Code 216725000), Brij 35 (Cat. No. 228345000), and copper (II) bromide (99 + %) (Cat. No. 206331000) were purchased from Acros Organics. Tetrahydrofuran, acetone, ethanol, and hydrochloric acid were purchased from Fisher Scientific. Carboxybetaine methacrylate (CBMA) was purchased from MedChem Express. 2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA),  4-((((2-Carboxyethyl)thio) carbono thioyl) thio)-4-cyanopentanoic acid (CTA), 4,4-azobis(4-cyanopentanoic acid) (ACVA), and sodium chloride (NaCl) were used as received from Sigma Aldrich and Fisher Scientific. RPMI 1640 media, penicillin-streptomycin, and fetal bovine serum (FBS), lipopolysaccharide (LPS), and macrophage colony-stimulating factor (MCSF) were all purchased from Fisher Scientific. MTS reagents (CellTiter 96 AQueous One Solution Cell Proliferation Assay) were obtained from Promega Corporation. Mission siRNA Fluorescent Universal Negative Control #2, 6-FAM (catalog #SIC008-5X1NMOL) was purchased from Sigma Aldrich. Mouse TNF-ɑ siRNA was purchased from Thermo Scientific (catalog #4390771), and the Mouse TNF-ɑ/TNFA/TNFSF2 ELISA Pair Set was sourced from Sino Biological (catalog #SEK50349-5).&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Table 1: Reagents Required for Nanocarrier Synthesis&lt;/strong&gt;&lt;/p&gt; &lt;table&gt; &lt;thead&gt; &lt;tr&gt; &lt;th align="left"&gt;&lt;strong&gt;Compound Name&lt;/strong&gt;&lt;/th&gt; &lt;th align="left"&gt;&lt;strong&gt;Role in Synthesis&lt;/strong&gt;&lt;/th&gt; &lt;th align="left"&gt;&lt;strong&gt;IUPAC/Chemical Name&lt;/strong&gt;&lt;/th&gt; &lt;th align="left"&gt;&lt;strong&gt;Chemical Structure&lt;/strong&gt;&lt;/th&gt; &lt;/tr&gt; &lt;/thead&gt; &lt;tbody&gt; &lt;tr&gt; &lt;td align="left"&gt;Copper(II) Bromide&lt;/td&gt; &lt;td align="left"&gt;Initiator&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;td align="left"&gt;CuBr₂&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Tris(2-pyridylmethyl)amine (TPMA)&lt;/td&gt; &lt;td align="left"&gt;Ligand&lt;/td&gt; &lt;td align="left"&gt;Tris[2-(pyridylmethyl)]amine&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Brij-30&lt;/td&gt; &lt;td align="left"&gt;Surfactant&lt;/td&gt; &lt;td align="left"&gt;Polyoxyethylene(4) lauryl ether&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Brij-35&lt;/td&gt; &lt;td align="left"&gt;Surfactant&lt;/td&gt; &lt;td align="left"&gt;Polyoxyethylene(23) lauryl ether&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Hexyl methacrylate (HMA)&lt;/td&gt; &lt;td align="left"&gt;Hydrophobic Co-monomer&lt;/td&gt; &lt;td align="left"&gt;2-methyl-2-propenoic acid hexyl ester&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Poly(ethylene glycol) methyl ether methacrylate (PEGMMA)&lt;/td&gt; &lt;td align="left"&gt;Hydrophilic Graft (PEG-NP)&lt;/td&gt; &lt;td align="left"&gt;Methacrylic acid, 2-[methoxy(polyethyleneoxy)propyl] ester&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Carboxybetaine methacrylate (CBMA)&lt;/td&gt; &lt;td align="left"&gt;Zwitterionic Graft&lt;/td&gt; &lt;td align="left"&gt;2-[(methacryloyloxy)ethyl]dimethylammonio]acetate&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Sulfobetaine methacrylate (SBMA)&lt;/td&gt; &lt;td align="left"&gt;Zwitterionic Graft&lt;/td&gt; &lt;td align="left"&gt;[2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Polymeric SBMA&lt;/td&gt; &lt;td align="left"&gt;Zwitterionic Graft Polymer&lt;/td&gt; &lt;td align="left"&gt;Poly-[2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Bis(2-methacryloyloxyethyl) disulfide&lt;/td&gt; &lt;td align="left"&gt;Crosslinking Agent&lt;/td&gt; &lt;td align="left"&gt;Disulfide-based dimethacrylate&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;2-(Dimethylamino)ethyl methacrylate (DMAEMA)&lt;/td&gt; &lt;td align="left"&gt;Cationic Co-monomer&lt;/td&gt; &lt;td align="left"&gt;Dimethylaminoethyl methacrylate&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Ascorbic Acid&lt;/td&gt; &lt;td align="left"&gt;Reducing Agent&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;td align="left"&gt;C₆H₈O₆&lt;/td&gt; &lt;/tr&gt; &lt;tr&gt; &lt;td align="left"&gt;Water&lt;/td&gt; &lt;td align="left"&gt;Solvent&lt;/td&gt; &lt;td align="left"&gt;&lt;br&gt;&lt;/td&gt; &lt;td align="left"&gt;H₂O&lt;/td&gt; &lt;/tr&gt; &lt;/tbody&gt; &lt;/table&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Synthesis via RAFT Polymerization:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;The synthesis of PSBMA was carried out by RAFT polymerization using a method previously described with slight modifications. To obtain a similar molecular weight to what was used for the PEG NPs, the ratio between SBMA and the CTA was carefully tailored. SBMA (1396.75 mg, 5 mmol, 7 equiv.), CTA (219.58 mg, 0.71 mmol, 1 equiv.), and ACVA (40 mg, 0.14 mmol, 0.2 equiv.) were dissolved in a 0.5 M NaCl solution (50% wt. with SBMA). The pH was adjusted to 7, and the solution was purged with nitrogen for 40 min. The solution was then left to polymerize at 70°C for 19h. Finally, after the reaction was finished, the polymer was lyophilized and stored until further use.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Synthesis of Cationic Nanoparticles via ARGET-ATRP:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;PEGMMA, CBMA, SBMA, and PSBMA NPs were synthesized using a one-pot oil-in-water emulsion polymerization approach via ARGET-ATRP process. Emulsions were created by mixing all reagents in a 1-dram glass vial in 2-mL batches and homogenizing them for 20 minutes with a 24-tip microtip sonicator probe (10s on/10s off cycle) (Sonicator Ultrasonic Processor XL from QSonica). Subsequently, the samples were transferred into an MBraun Glovebox LABmaster 130 under inert nitrogen conditions (O&lt;sub&gt;2&lt;/sub&gt;&amp;lt;0.1 ppm; H&lt;sub&gt;2&lt;/sub&gt;O &amp;lt;0.1 ppm) to initiate the reaction by adding ascorbic acid. After 24 hours, the reaction was stopped by exposing the samples to air and diluting them to a 0.5 N concentration by adding 4N HCl. Unreacted monomers and impurities were removed from the NPs using ionomer collapse, which involves acidifying the samples and precipitating them with a low dielectric constant solvent like tetrahydrofuran. The nanogels were precipitated through ionomer collapse three times and collected after each cycle by centrifugation at 4000g for 5 minutes. Following the final centrifugation, the NPs were resuspended in 5 mL of deionized water and dialyzed against deionized water for at least 7 days to eliminate any residual tetrahydrofuran &lt;sup&gt;38&lt;/sup&gt;. CBMA and SBMA particles were synthesized at two different monomer input volumes to investigate the effect of zwitterionic concentration. CBMA and SBMA were synthesized using 11 μL and 13 μL of 2 mg/mL zwitterionic stock solutions, respectively.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Nuclear Magnetic Resonance:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;The &lt;sup&gt;1&lt;/sup&gt;H^^ Nuclear Magnetic Resonance (NMR) spectrum of PSBMA was obtained using a Bruker 500 MHz NMR spectrometer. PSBMA was dissolved in D&lt;sub&gt;2&lt;/sub&gt;O at a 5 mg/mL concentration and analyzed using the MestReNova 14.3.0 software.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Fourier-Transformed Infrared Spectroscopy:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;The Fourier-Transformed Infrared (FTIR) Spectroscopy spectrum of PSBMA was acquired using an Attenuated Total Reflectance FTIR through a germanium crystal on a Nicolet iS10 spectrometer with a SMART iTX accessory, both from Thermo Scientific. The lyophilized sample was analyzed by placing it on the crystal after the background spectrum was collected. The spectrum was analyzed using Omnic software.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Characterizing Nanoparticle Size &amp;amp; Electrophoretic Potential:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;The hydrodynamic diameters and zeta potentials of the NPs were determined using dynamic light scattering (DLS) and zeta potential measurements on a Malvern ZetaSizer (NanoZS). For DLS characterization, the stock NPs solution was diluted 66.67 times in 1X PBS (75 μL NP: 5 mL PBS) to a final volume of 5 mL. Measurements were taken at pH 3-5 (acidic), pH 6-7 (neutral), and pH 9 (basic) to assess NPs size and monodispersity (expressed as the polydispersity index, PDI). The volume swelling ratio was calculated by:&lt;/p&gt; &lt;p&gt;where &lt;em&gt;V&lt;/em&gt; is the respective volume at each pH, which simplifies to each diameter (&lt;em&gt;d&lt;/em&gt;) at each pH cubed. Zeta potential measurements were performed on diluted NPs (150 μL NP: 6 mL 5 mM sodium phosphate buffer) at pH 3-5 (acidic) and pH 6-7 (neutral). Folded capillary zeta cells were used for these measurements. All DLS and zeta potential readings were conducted in triplicate using standardized protocols optimized for cationic NPs.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Monocyte Isolation &amp;amp; Culture:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;Bone marrow-derived monocytes were isolated from the hindlimbs of male and female FVBn mice (all littermates, 6-8 weeks old; N=3 per sex) and cultured as described by Rybalko et al. Bones from the hindlimbs of the mice were extracted, and marrow was subsequently isolated in the cell culture hood by flushing bones with sterile PBS. Cells were centrifuged at 500g for 5 min and resuspended in RPMI-1640 supplemented with 10% FBS and 1% penicillin–streptomycin, along with MCSF (10 ng/mL) at a density of 1 × 10⁶ cells/mL. For 96-well plates, 100 μl of cells (1 × 10&lt;sup&gt;6&lt;/sup&gt; cells/ml) were added to each well. Media with fresh MCSF was added on days 3, 5, and 7 to differentiate monocytes into macrophages. Experiments were performed beginning on day 7.&lt;/p&gt; &lt;p&gt;All experiments (cytotoxicity, uptake, and TNF-α knockdown) included N = 3 biological replicates per sex, with n = 6–9 technical replicates per condition. Samples were not pooled; each biological replicate corresponds to cells derived from a single mouse. The same batch of cells from each animal was used across all assays to ensure consistency between endpoints.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Cytotoxicity:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;The cytotoxicity of the NPs was assessed using the colorimetric CellTiter 96 AQueous One Solution Cell Proliferation Assay kit. This kit uses a soluble tetrazolium salt, [3-[4,5-dimethylthiazol-2-yl]-5-(3-carboxymethyl phenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS), which is bio-reduced by viable cells into a purple formazan product. The level of MTS bio-reduction correlates with the metabolism of the cells, which is often used as a measure of cell viability. NPs were tested on primary murine monocytes grown to 40,000 cells per well. On day 7, NPs were added to the cell culture medium at concentrations of 12.5, 50, 125, and 500 μg/ml. After 24 hours of NP exposure, the cells were washed twice with DPBS and resuspended in assay media (16.67% MTS reagent, 83.33% growth media without phenol red). The plates were incubated for 2 hours at 37°C and 5% CO&lt;sub&gt;2&lt;/sub&gt;, after which absorbance readings were taken at 490 using a Biotek Cytation 3 Plate Reader.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Fluorescent siRNA Loading and Uptake in Primary Monocytes:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;NPs (5000 ng/ml) were loaded at a 10:1 NP: siRNA ratio with 500 ng/ml fluorescent siRNA (fluorescent siRNA or anti-TNF-ɑ siRNA) in sterile 1% DEPC-treated PBS at pH 5.5, vortexed, and allowed to incubate for one hour in the dark. Loaded NPs were centrifuged at 15,000 x g for 10 min, and the loading supernatant was removed and replaced with 500 μL of cell culture medium. Loaded NPs solutions were then added to the cells at 12.5 μg/ml for 24 hours. Wells were then washed twice with DPBS and placed in phenol-free RPMI 1640 culture medium. Wells were imaged using an Incucyte S3 Live Cell Analysis Instrument (Sartorius). The phase contrast and green fluorescent channels were used to measure the cells and siRNA, respectively, with three wells per condition. The Incucyte software was used to measure cell confluency and fluorescence intensity within the cells. Relative uptake was then calculated via:&lt;/p&gt; &lt;p&gt; (Fluorescence Intensity per Area)/(Cell Confluency)=Relative Uptake&lt;/p&gt; &lt;p&gt; A control condition using NPs without fluorescent siRNA (blank NPs) was included to account for background fluorescence. The average signal from this control was subtracted from all uptake values.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;TNF-ɑ Knockdown:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;NPs loaded with anti-TNF-ɑ siRNA were centrifuged at 15,000g for 10 min, and the loading supernatant was removed and replaced with 500 μL of cell culture medium. Simultaneously, mouse macrophages were cultured as previously described and were treated with LPS at 50 ng/ml overnight to induce TNF-ɑ production. Macrophages were then treated with NPs at 12.5 μg/ml. After 24 hours, the treated cell media was collected. TNF-ɑ content was assessed with an enzyme-linked immunosorbent assay kit manufactured by Sino Biological. The standard curve was plotted using a 4-parameter logistic curve. Percent TNF-ɑ knockdown was calculated by normalizing to the LPS-stimulated control of the specified sex.&lt;/p&gt; &lt;p&gt;&lt;em&gt;&lt;strong&gt;Statistical Analyses:&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;All experiments were run in triplicate. Primary cell experiments were done with biological triplicates (n=3) for each sex (male, female), with technical replicates for each assay ranging from 3-6. For technical replicates, the mean values were found. Values are reported as the biological mean ± standard deviation unless otherwise noted in the figure caption. Data were plotted in Microsoft Excel and GraphPad Prism. All statistics were run in GraphPad Prism as t-tests, one-way ANOVA, or two-way ANOVA (sex + nanoparticle treatment considered multiple variables) with a post-hoc analysis using Tukey HSD or Šidák’s. Reported significant results are p &amp;lt; 0.05 unless otherwise stated.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Surface chemistry governs sex-dependent responses to PEG and
      zwitterionic NPs Dataset DOI:
      [10.5061/dryad.905qftv1c](https://doi.org/10.5061/dryad.905qftv1c) ##
      Description of the data and file structure We have submitted our raw data
      for nanoparticle size and PDI acquired from dynamic light scattering
      (Data_SizeandPDI.csv), metabolic activity assays
      (Cytotoxicity_Zwitterion.csv), nanoparticle cell uptake via Incucyte
      (NPUptake_Zwitterion.csv), and TNF-alpha knockdown via ELISA
      (TNFELISA_Zwitterion.csv). Dataset DOI:
      [10.5061/dryad.905qftv1c](https://doi.org/10.5061/dryad.905qftv1c) ###
      Files and variables #### File: Cytotoxicty_Zwitterion.xlsx
      **Description:** This dataset provides raw data from our cell metabolic
      activity assay. The cytotoxicity of the nanoparticles was assessed using
      the colorimetric CellTiter 96 AQueous One Solution Cell Proliferation
      Assay kit. This kit uses a soluble tetrazolium salt,
      [3-[4,5-dimethylthiazol-2-yl]-5-(3-carboxymethyl
      phenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS), which is bio-reduced by
      viable cells into a purple formazan product. The level of MTS
      bio-reduction correlates with the metabolism of the cells, which is often
      used as a measure of cell viability. NPs were tested on primary murine
      monocytes grown to 40,000 cells per well. On day 7, NPs were added to the
      cell culture medium at concentrations of 12.5, 50, 125, and 500 μg/ml.
      After 24 hours of NP exposure, the cells were washed twice with DPBS and
      resuspended in assay media (16.67% MTS reagent, 83.33% growth media
      without phenol red). The plates were incubated for 2 hours at 37°C and 5%
      CO~2~, after which absorbance readings were taken at 490 using a Biotek
      Cytation 3 Plate Reader. This dataset shows the raw absorbance readings.
      We then converted the absorbance values to relative metabolic activity
      compared to the untreated control for each corresponding animal. #####
      Variables * *Sample*: This indicates sample information on nanoparticle
      population PEGMMA, SBMA, CBMA, or PSBMA, or the control. The control here
      indicates cells that were untreated and left to grow in media only. *
      *Animal*: This indicates which biological replicate the cells were from.
      We had three females and three males indicated as Female 1, Female 2,
      Female 3, Male 1, Male 2, and Male 3. * *Concentration*: This is the
      concentration of nanoparticles added to each well with cells. *
      *Absorbance 1*: The first technical replicate for absorbance. *
      *Absorbance 2*: The second technical replicate for absorbance. *
      *Absorbance 3*: The third technical replicate for absorbance. #### File:
      Data_SizeandPDI.xlsx **Description:** This dataset provides raw dynamic
      light scattering (DLS) data for size and PDI of nanoparticles used in our
      study. The temperature was set to 25°C for all measurements and the DLS
      measurements were performed at a 173° angle. ##### Variables * *Sample
      Name*: This gives information on which nanoparticle population is being
      measured from our paper, including PEGMMA, SBMA, CBMA, and PSBMA
      nanoparticle formulations. It also tells at which pH the measurement was
      run. Measurements of the nanoparticles were done at pH 3-5, pH 6-7, and pH
      9. * *Z-Average*: This is the average hydrodynamic diameter given by the
      equipment in nm for the nanoparticles. * *PdI*: This is the polydispersity
      index of the nanoparticle formulation, which describes how monodisperse
      the sample is. * *Mean count rate*: This is a parameter from the DLS
      equipment that shows the count of particles it is getting in kcps. This is
      associated with the size and PDI measurements. * *ZP*: This is the zeta
      potential in mV of the nanoparticles. NA indicates not applicable as zeta
      potential measurements were only taken 3 times, and were not run at pH
      9.          #### File: NPUptake_Zwitterion.xlsx **Description:** This
      dataset was run using the Incucyte. NPs (5000 ng/ml) were loaded at a 10:1
      NP: siRNA ratio with 500 ng/ml fluorescent siRNA (fluorescent siRNA or
      anti-TNF-ɑ siRNA) in sterile 1% DEPC-treated PBS at pH 5.5, vortexed, and
      allowed to incubate for one hour in the dark. Loaded NPs were centrifuged
      at 15,000 x g for 10 min, and the loading supernatant was removed and
      replaced with 500 μL of cell culture medium. Loaded NPs solutions were
      then added to the cells at 12.5 μg/ml for 24 hours. Wells were then washed
      twice with DPBS and placed in phenol-free RPMI 1640 culture medium. Wells
      were imaged using an Incucyte S3 Live Cell Analysis Instrument
      (Sartorius). The phase contrast and green fluorescent channels were used
      to measure the cells and siRNA, respectively, with three wells per
      condition. This is the raw data from the Incucyte indicating siRNA
      integrated intensity object which was a fluorescent measurement done by
      the Incucyte divided by cell area confluence which was taken via phase
      contrast in the Incucyte. A control condition using NPs without
      fluorescent siRNA (blank NPs) was included to account for background
      fluorescence. The average signal from this control was subtracted from all
      uptake values for the corresponding animal. ##### Variables * *Sample*:
      This indicates sample information on nanoparticle population PEGMMA, SBMA,
      CBMA, or PSBMA loaded with fluorescent siRNA, or the control. A control
      condition using NPs without fluorescent siRNA (blank NPs) was included to
      account for background fluorescence. * *Animal*: This indicates which
      biological replicate the cells were from. We had three females and three
      males indicated as Female 1, Female 2, Female 3, Male 1, Male 2, and Male
      3. * *siRNA Integrated Intensity Object/Cell Area Confluence*: The
      fluorescent signal of each sample calculated by the Incucyte with the
      green fluorescent channel, divided by the cell area confluence calculated
      by the Incucyte based on surface coverage of the cells in the surface
      contract images. #### File: TNFELISA_Zwitterion.xlsx
      **Description:** Nanoparticles loaded with anti-TNF-ɑ siRNA were
      centrifuged at 15,000g for 10 min, and the loading supernatant was removed
      and replaced with 500 μL of cell culture medium. Simultaneously, mouse
      macrophages were cultured as previously described and were treated with
      LPS at 50 ng/ml overnight to induce TNF-ɑ production. Macrophages were
      then treated with NPs at 12.5 μg/ml. After 24 hours, the treated cell
      media was collected. TNF-ɑ content was assessed with an enzyme-linked
      immunosorbent assay kit manufactured by Sino Biological. The standard
      curve was plotted using a 4-parameter logistic curve. Percent TNF-ɑ
      knockdown was calculated by normalizing to the LPS-stimulated control of
      the specified sex. This is the raw data for the absorbance values of the
      ELISA. ##### Variables * *Sample*: This indicates sample information on
      nanoparticle population PEGMMA, SBMA, CBMA, or PSBMA loaded with TNF
      siRNA, or the LPS control which was not treated with nanoparticles.
      Additionally, the standard curve is shown (0, 93.75, 187.5, 375, 750,
      1500, 3000 pg/ml TNF are indicated by the corresponding numbered samples).
      * *Animal*: This indicates which biological replicate the cells were from.
      We had three females and three males indicated as F1, F2, F3, M1, M2, and
      M3. * *Abs1*: The first technical replicate for absorbance. * *Abs 2*: The
      second technical replicate for absorbance. * *Abs3*: The third technical
      replicate for absorbance. ## Code/software CSV files can be opened with
      any compatible software. Data were analyzed using GraphPad Prism and
      Microsoft Excel. ## Access information Other publicly accessible locations
      of the data: * Not applicable Data were derived from the following
      sources: * Not applicable
    </description>
  </descriptions>
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