{"data":{"id":"10.5061/dryad.853nh","type":"dois","attributes":{"doi":"10.5061/dryad.853nh","prefix":"10.5061","suffix":"dryad.853nh","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Huijben, Silvie","nameType":"Personal","givenName":"Silvie","familyName":"Huijben","affiliation":["Park University"],"nameIdentifiers":[]},{"name":"Sim, Derek G.","nameType":"Personal","givenName":"Derek G.","familyName":"Sim","affiliation":["Park University"],"nameIdentifiers":[]},{"name":"Nelson, William A.","nameType":"Personal","givenName":"William A.","familyName":"Nelson","affiliation":["Queen's University"],"nameIdentifiers":[]},{"name":"Read, Andrew F.","nameType":"Personal","givenName":"Andrew F.","familyName":"Read","affiliation":["Park University"],"nameIdentifiers":[]}],"titles":[{"title":"Data from: The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection"}],"publisher":"Dryad","container":{},"publicationYear":2011,"subjects":[{"subject":"within-host dynamics"},{"subject":"selection coefficient"},{"subject":"competitive release"},{"subject":"multiplicity of infection"},{"subject":"Drug resistance"},{"subject":"Malaria","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"complexity of infection"},{"subject":"Plasmodium chabaudi"}],"contributors":[],"dates":[{"date":"2011-07-18T15:32:24Z","dateType":"Submitted"},{"date":"2011-07-19T16:09:10Z","dateType":"Issued"},{"date":"2011-07-19T16:09:10Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1111/j.1420-9101.2011.02369.x","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["395340 bytes"],"formats":[],"version":"1","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Malaria infections normally consist of more than one clonally-replicating\n lineage. Within-host interactions between sensitive and resistant\n parasites can have profound effects on the evolution of drug resistance.\n Here, using the Plasmodium chabaudi mouse malaria model, we ask whether\n the costs and benefits of resistance are affected by the number of\n co-infecting strains competing with a resistant clone. We found strong\n competitive suppression of resistant parasites in untreated infections and\n marked competitive release following treatment. The magnitude of\n competitive suppression depended on competitor identity. However, there\n was no overall effect of the diversity of susceptible parasites on the\n extent of competitive suppression or release. If these findings\n generalize, then transmission intensity will impact on resistance\n evolution because of its effect on the frequency of mixed infections, not\n because of its effect on the distribution of clones per host. This would\n greatly simplify the computational problems of adequately capturing\n within-host ecology in models of drug resistance evolution in malaria.","descriptionType":"Abstract"},{"description":"Data SH4 Dryad data\n sharingData file of the\n experiment 'SH4'. Samples are from mice infected with a\n resistant Plasmodium chabaudi clone in the absence of competition and with\n various combinations of up to three susceptible clones. Daily samples were\n taken on red blood cell density, weight, asexual parasite density of each\n clone (by qPCR) and gametocyte density of clone R (by qPCR). The\n description of the column headings are all given as comments in the excel\n 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