{"data":{"id":"10.5061/dryad.73f23","type":"dois","attributes":{"doi":"10.5061/dryad.73f23","prefix":"10.5061","suffix":"dryad.73f23","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Cizauskas, Carrie A.","nameType":"Personal","givenName":"Carrie A.","familyName":"Cizauskas","affiliation":["Princeton University","University of California, Berkeley"],"nameIdentifiers":[]},{"name":"Bellan, Steven E.","nameType":"Personal","givenName":"Steven E.","familyName":"Bellan","affiliation":["The University of Texas at Austin","University of California, Berkeley"],"nameIdentifiers":[]},{"name":"Turner, Wendy C.","nameType":"Personal","givenName":"Wendy C.","familyName":"Turner","affiliation":["University of California, Berkeley","University of Oslo"],"nameIdentifiers":[]},{"name":"Vance, Russell E.","nameType":"Personal","givenName":"Russell E.","familyName":"Vance","affiliation":["University of California, Berkeley"],"nameIdentifiers":[]},{"name":"Getz, Wayne M.","nameType":"Personal","givenName":"Wayne M.","familyName":"Getz","affiliation":["University of KwaZulu-Natal","University of California, Berkeley"],"nameIdentifiers":[]}],"titles":[{"title":"Data from: Frequent and seasonally variable sublethal anthrax infections are accompanied by short-lived immunity in an endemic system"}],"publisher":"Dryad","container":{},"publicationYear":2014,"subjects":[{"subject":"Bacillus anthracis","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"seroconversion dynamics"},{"subject":"Loxodonta africana"},{"subject":"Microbiology","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"ecological immunology"},{"subject":"microparasites"},{"subject":"Antidorcas marsupialis"},{"subject":"Endoparasites"},{"subject":"Equus quagga"},{"subject":"antibody persistence"},{"subject":"Serology","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"host-parasite interactions"}],"contributors":[],"dates":[{"date":"2014-01-21T23:59:29Z","dateType":"Submitted"},{"date":"2014-02-06T16:46:07Z","dateType":"Issued"},{"date":"2014-02-06T16:46:07Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1111/1365-2656.12207","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["46465 bytes"],"formats":[],"version":"1","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"1. Few studies have examined host-pathogen interactions in wildlife from\n an immunological perspective, particularly in the context of seasonal and\n longitudinal dynamics. In addition, though most ecological immunology\n studies employ serological antibody assays, endpoint titer determination\n is usually based on subjective criteria and needs to be made more\n objective. 2. Despite the fact that anthrax is an ancient and emerging\n zoonotic infectious disease found worldwide, its natural ecology is not\n well understood. In particular, little is known about the adaptive immune\n responses of wild herbivore hosts against Bacillus anthracis. 3. Working\n in the natural anthrax system of Etosha National Park, Namibia, we\n collected 154 serum samples from plains zebra (Equus quagga), 21 from\n springbok (Antidorcas marsupialis), and 45 from African elephants\n (Loxodonta africana) over 2-3 years, resampling individuals when possible\n for seasonal and longitudinal comparisons. We used enzyme-linked\n immunosorbent assays to measure anti-anthrax antibody titers and developed\n three increasingly conservative models to determine endpoint titers with\n more rigorous, objective mensuration. 4. Between 52-87% of zebra, 0-15% of\n springbok, and 3-52% of elephants had measurable anti-anthrax antibody\n titers, depending on the model used. While the ability of elephants and\n springbok to mount anti-anthrax adaptive immune responses is still\n equivocal, our results indicate that zebra in ENP often survive sublethal\n anthrax infections, encounter most B. anthracis in the wet season, and can\n partially booster their immunity to B. anthracis. 5. Thus, rather than\n being solely a lethal disease, anthrax often occurs as a sublethal\n infection in some susceptible hosts. Though we found that adaptive\n immunity to anthrax wanes rapidly, subsequent and frequent sublethal B.\n anthracis infections cause maturation of anti-anthrax immunity. By\n triggering host immune responses, these common sublethal infections may\n act as immunomodulators and affect population dynamics through indirect\n immunological and co-infection effects. 6. In addition, with our three\n endpoint titer models, we introduce more mensuration rigor into\n serological antibody assays, even under the often-restrictive conditions\n that come with adapting laboratory immunology methods to wild systems.\n With these methods we identified significantly more zebras responding\n immunologically to anthrax than have previous studies using less\n comprehensive titer analyses.","descriptionType":"Abstract"},{"description":"Anti-PA Titers for Equus\n quaggaAnti-anthrax\n (anti-protective antigen toxin) antibody titers for wild plains zebra\n immobilized and sampled over 1-5 seasons in Etosha National Park, Namibia.\n id=animal capture ID. titer=anti-PA titer; the titer is the highest\n dilution in the titration series for which the mean sample optical density\n (OD) for that dilution is greater than the mean negative control OD\n titration curve from all plates (dilution is as 1:dilution; e.g. 1024 is a\n 1:1024 dilution). titerDUP=anti-PA titer for which the titer is the last\n dilution at which the mean sample OD is greater than the mean negative\n control OD buffered by a 95% confidence interval determined by the\n inter-duplicate error at that dilution, across all samples.\n titerNCONT=anti-PA titer for which the titer is the last dilution at which\n the mean sample OD is greater than the mean negative control OD buffered\n by a 95% confidence interval determined by the inter-negative control\n error at that dilution, across all samples. plate=plate identifier (date\n and plate number on that day). ncont=identifier of the negative control\n sample used.EQtitersPA.csvAnti-PA Titers for Antidorcas marsupialisAnti-anthrax (anti-protective antigen toxin) antibody titers for wild springbok immobilized and sampled over 1-2 seasons in Etosha National Park, Namibia. id=animal capture ID. titer=anti-PA titer; the titer is the highest dilution in the titration series for which the mean sample optical density (OD) for that dilution is greater than the mean negative control OD titration curve from all plates (dilution is as 1:dilution; e.g. 1024 is a 1:1024 dilution). titerDUP=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-duplicate error at that dilution, across all samples. titerNCONT=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-negative control error at that dilution, across all samples. plate=plate identifier (date and plate number on that day). ncont=identifier of the negative control sample used.AMtitersPA.csvAnti-PA Titers for Loxodonta africanaAnti-anthrax (anti-protective antigen toxin) antibody titers for wild African elephants immobilized and sampled over 1-2 seasons in Etosha National Park, Namibia. id=animal capture ID. titer=anti-PA titer; the titer is the highest dilution in the titration series for which the mean sample optical density (OD) for that dilution is greater than the mean negative control OD titration curve from all plates (dilution is as 1:dilution; e.g. 1024 is a 1:1024 dilution). titerDUP=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-duplicate error at that dilution, across all samples. titerNCONT=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-negative control error at that dilution, across all samples. plate=plate identifier (date and plate number on that day). ncont=identifier of the negative control sample used.LAtitersPA.csv","descriptionType":"Other"}],"geoLocations":[{"geoLocationPlace":"Namibia"},{"geoLocationPlace":"Etosha National Park"}],"fundingReferences":[],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.73F23</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Cizauskas, Carrie A.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00hx57361" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Princeton University</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/01an7q238" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Berkeley</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Bellan, Steven E.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00hj54h04" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The University of Texas at Austin</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/01an7q238" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Berkeley</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Turner, Wendy C.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01an7q238" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Berkeley</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/01xtthb56" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Oslo</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Vance, Russell E.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01an7q238" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Berkeley</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Getz, Wayne M.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04qzfn040" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of KwaZulu-Natal</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/01an7q238" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Berkeley</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Data from: Frequent and seasonally variable sublethal anthrax infections
      are accompanied by short-lived immunity in an endemic system
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2014</publicationYear>
  <subjects>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Bacillus anthracis</subject>
    <subject>seroconversion dynamics</subject>
    <subject>Loxodonta africana</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Microbiology</subject>
    <subject>ecological immunology</subject>
    <subject>microparasites</subject>
    <subject>Antidorcas marsupialis</subject>
    <subject>Endoparasites</subject>
    <subject>Equus quagga</subject>
    <subject>antibody persistence</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Serology</subject>
    <subject>host-parasite interactions</subject>
  </subjects>
  <dates>
    <date dateType="Submitted">2014-01-21T23:59:29Z</date>
    <date dateType="Issued">2014-02-06T16:46:07Z</date>
    <date dateType="Available">2014-02-06T16:46:07Z</date>
  </dates>
  <language>en</language>
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  <descriptions>
    <description descriptionType="Abstract">
      1. Few studies have examined host-pathogen interactions in wildlife from
      an immunological perspective, particularly in the context of seasonal and
      longitudinal dynamics. In addition, though most ecological immunology
      studies employ serological antibody assays, endpoint titer determination
      is usually based on subjective criteria and needs to be made more
      objective. 2. Despite the fact that anthrax is an ancient and emerging
      zoonotic infectious disease found worldwide, its natural ecology is not
      well understood. In particular, little is known about the adaptive immune
      responses of wild herbivore hosts against Bacillus anthracis. 3. Working
      in the natural anthrax system of Etosha National Park, Namibia, we
      collected 154 serum samples from plains zebra (Equus quagga), 21 from
      springbok (Antidorcas marsupialis), and 45 from African elephants
      (Loxodonta africana) over 2-3 years, resampling individuals when possible
      for seasonal and longitudinal comparisons. We used enzyme-linked
      immunosorbent assays to measure anti-anthrax antibody titers and developed
      three increasingly conservative models to determine endpoint titers with
      more rigorous, objective mensuration. 4. Between 52-87% of zebra, 0-15% of
      springbok, and 3-52% of elephants had measurable anti-anthrax antibody
      titers, depending on the model used. While the ability of elephants and
      springbok to mount anti-anthrax adaptive immune responses is still
      equivocal, our results indicate that zebra in ENP often survive sublethal
      anthrax infections, encounter most B. anthracis in the wet season, and can
      partially booster their immunity to B. anthracis. 5. Thus, rather than
      being solely a lethal disease, anthrax often occurs as a sublethal
      infection in some susceptible hosts. Though we found that adaptive
      immunity to anthrax wanes rapidly, subsequent and frequent sublethal B.
      anthracis infections cause maturation of anti-anthrax immunity. By
      triggering host immune responses, these common sublethal infections may
      act as immunomodulators and affect population dynamics through indirect
      immunological and co-infection effects. 6. In addition, with our three
      endpoint titer models, we introduce more mensuration rigor into
      serological antibody assays, even under the often-restrictive conditions
      that come with adapting laboratory immunology methods to wild systems.
      With these methods we identified significantly more zebras responding
      immunologically to anthrax than have previous studies using less
      comprehensive titer analyses.
    </description>
    <description descriptionType="Other">
      &lt;div class="o-metadata__file-usage-entry"&gt;&lt;h4
      class="o-heading__level3-file-title"&gt;Anti-PA Titers for Equus
      quagga&lt;/h4&gt;&lt;div
      class="o-metadata__file-description"&gt;Anti-anthrax
      (anti-protective antigen toxin) antibody titers for wild plains zebra
      immobilized and sampled over 1-5 seasons in Etosha National Park, Namibia.
      id=animal capture ID. titer=anti-PA titer; the titer is the highest
      dilution in the titration series for which the mean sample optical density
      (OD) for that dilution is greater than the mean negative control OD
      titration curve from all plates (dilution is as 1:dilution; e.g. 1024 is a
      1:1024 dilution). titerDUP=anti-PA titer for which the titer is the last
      dilution at which the mean sample OD is greater than the mean negative
      control OD buffered by a 95% confidence interval determined by the
      inter-duplicate error at that dilution, across all samples.
      titerNCONT=anti-PA titer for which the titer is the last dilution at which
      the mean sample OD is greater than the mean negative control OD buffered
      by a 95% confidence interval determined by the inter-negative control
      error at that dilution, across all samples. plate=plate identifier (date
      and plate number on that day). ncont=identifier of the negative control
      sample used.&lt;/div&gt;&lt;div
      class="o-metadata__file-name"&gt;EQtitersPA.csv&lt;/br&gt;&lt;/div&gt;&lt;/div&gt;&lt;div class="o-metadata__file-usage-entry"&gt;&lt;h4 class="o-heading__level3-file-title"&gt;Anti-PA Titers for Antidorcas marsupialis&lt;/h4&gt;&lt;div class="o-metadata__file-description"&gt;Anti-anthrax (anti-protective antigen toxin) antibody titers for wild springbok immobilized and sampled over 1-2 seasons in Etosha National Park, Namibia. id=animal capture ID. titer=anti-PA titer; the titer is the highest dilution in the titration series for which the mean sample optical density (OD) for that dilution is greater than the mean negative control OD titration curve from all plates (dilution is as 1:dilution; e.g. 1024 is a 1:1024 dilution). titerDUP=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-duplicate error at that dilution, across all samples. titerNCONT=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-negative control error at that dilution, across all samples. plate=plate identifier (date and plate number on that day). ncont=identifier of the negative control sample used.&lt;/div&gt;&lt;div class="o-metadata__file-name"&gt;AMtitersPA.csv&lt;/br&gt;&lt;/div&gt;&lt;/div&gt;&lt;div class="o-metadata__file-usage-entry"&gt;&lt;h4 class="o-heading__level3-file-title"&gt;Anti-PA Titers for Loxodonta africana&lt;/h4&gt;&lt;div class="o-metadata__file-description"&gt;Anti-anthrax (anti-protective antigen toxin) antibody titers for wild African elephants immobilized and sampled over 1-2 seasons in Etosha National Park, Namibia. id=animal capture ID. titer=anti-PA titer; the titer is the highest dilution in the titration series for which the mean sample optical density (OD) for that dilution is greater than the mean negative control OD titration curve from all plates (dilution is as 1:dilution; e.g. 1024 is a 1:1024 dilution). titerDUP=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-duplicate error at that dilution, across all samples. titerNCONT=anti-PA titer for which the titer is the last dilution at which the mean sample OD is greater than the mean negative control OD buffered by a 95% confidence interval determined by the inter-negative control error at that dilution, across all samples. plate=plate identifier (date and plate number on that day). ncont=identifier of the negative control sample used.&lt;/div&gt;&lt;div class="o-metadata__file-name"&gt;LAtitersPA.csv&lt;/br&gt;&lt;/div&gt;&lt;/div&gt;
    </description>
  </descriptions>
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    <geoLocation>
      <geoLocationPlace>Namibia</geoLocationPlace>
    </geoLocation>
    <geoLocation>
      <geoLocationPlace>Etosha National Park</geoLocationPlace>
    </geoLocation>
  </geoLocations>
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