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In 9 out of 10 cases, the molecular cause, however, is unknown.\n One mechanistic hypothesis involves impaired endothelium-dependent\n vasodilation through reactive oxygen species (ROS) formation. Indeed, ROS\n forming NADPH oxidase (Nox) genes associate with hypertension, yet target\n validation has been negative. We re-investigate this association by\n molecular network analysis and identify NOX5, not present in rodents, as a\n sole neighbor to human vasodilatory endothelial nitric oxide (NO)\n signaling. In hypertensive patients, endothelial microparticles indeed\n contained higher levels of NOX5—but not NOX1, NOX2, or NOX4—with a bimodal\n distribution correlating with disease severity. Mechanistically, mice\n expressing human Nox5 in endothelial cells developed—upon aging—severe\n systolic hypertension and impaired endothelium-dependent vasodilation due\n to uncoupled NO synthase (NOS). We conclude that NOX5-induced uncoupling\n of endothelial NOS is a causal mechanism and theragnostic target of an\n age-related hypertension endotype. Nox5 knock-in (KI) mice represent the\n first mechanism-based animal model of hypertension.","descriptionType":"Abstract"},{"description":"CD144+ microparticles were isolated as described with\n modifications (see paper). Briefly, Dynabeads G (Invitrogen, Carlsbad, CA)\n were washed with PBS containing 0.1% BSA and then reconstituted with PBS.\n Anti-CD144 antibody (Santa Cruz Biotechnology, Dallas, TX), which\n specifically targets endothelial cells, was mixed with prewashed Dynabeads\n G for 2 hours and then incubated with plasma samples at 1:200 dilution\n overnight at 4°C. After precipitation, Dynabeads G were washed with PBS\n and 1% Tween-20 three times. The purity of CD144+ MPs, determined by FACS\n analysis, was 70% ± 5.6%. With the use of FITC-conjugated beads as size\n references, the size of such particles was assessed to be \u0026lt;0.5 μm\n in diameter. The baseline characteristics of those patients are listed in\n S1 Table. The values provided for Fig. S1 in the article’s S1 Data file\n are ng/mL values calculated from optical density (O.D.)\n measurements.","descriptionType":"Methods"},{"description":"The dataset contains repeated values for Fig. S1A because NOX1\n concentrations were very close to the limit of detection, i.e., close to\n the O.D. of the buffer control for which we obtained a value of 0.09. The\n repeated values in the 0.07-0.16 range were interpreted as essentially\n negative results, and from these data we concluded that NOX1 was not\n detectable using this assay for most subjects. Only one normotensive and\n two hypertensive patients with microalbuminuria yielded O.D. readings\n above the 0.07-0.16 range.","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"European Commission","awardNumber":"REPO-TRIAL 777111","funderIdentifier":"https://ror.org/00k4n6c32","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"European Research Council","awardNumber":"AdG RadMed 29468","funderIdentifier":"https://ror.org/0472cxd90","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"European Research Council","awardNumber":"PoC SAVEBRAIN 737586","funderIdentifier":"https://ror.org/0472cxd90","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"The Velux Foundations","awardNumber":"Young Investigator grant","funderIdentifier":"https://ror.org/007ww2d15","funderIdentifierType":"ROR"},{"funderName":"H2020 European Research Council","awardNumber":"294683"},{"funderName":"H2020 European Research Council","awardNumber":"737586"},{"funderName":"Horizon 2020","awardNumber":"777111"},{"funderName":"VILLUM Young Investigator grant.","awardNumber":"13154"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism
      and theragnostic target of an age-related hypertension endotype
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      Hypertension is the most important cause of death and disability in the
      elderly. In 9 out of 10 cases, the molecular cause, however, is unknown.
      One mechanistic hypothesis involves impaired endothelium-dependent
      vasodilation through reactive oxygen species (ROS) formation. Indeed, ROS
      forming NADPH oxidase (Nox) genes associate with hypertension, yet target
      validation has been negative. We re-investigate this association by
      molecular network analysis and identify NOX5, not present in rodents, as a
      sole neighbor to human vasodilatory endothelial nitric oxide (NO)
      signaling. In hypertensive patients, endothelial microparticles indeed
      contained higher levels of NOX5—but not NOX1, NOX2, or NOX4—with a bimodal
      distribution correlating with disease severity. Mechanistically, mice
      expressing human Nox5 in endothelial cells developed—upon aging—severe
      systolic hypertension and impaired endothelium-dependent vasodilation due
      to uncoupled NO synthase (NOS). We conclude that NOX5-induced uncoupling
      of endothelial NOS is a causal mechanism and theragnostic target of an
      age-related hypertension endotype. Nox5 knock-in (KI) mice represent the
      first mechanism-based animal model of hypertension.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;CD144+ microparticles were isolated as described with
      modifications (see paper). Briefly, Dynabeads G (Invitrogen, Carlsbad, CA)
      were washed with PBS containing 0.1% BSA and then reconstituted with PBS.
      Anti-CD144 antibody (Santa Cruz Biotechnology, Dallas, TX), which
      specifically targets endothelial cells, was mixed with prewashed Dynabeads
      G for 2 hours and then incubated with plasma samples at 1:200 dilution
      overnight at 4°C. After precipitation, Dynabeads G were washed with PBS
      and 1% Tween-20 three times. The purity of CD144+ MPs, determined by FACS
      analysis, was 70% ± 5.6%. With the use of FITC-conjugated beads as size
      references, the size of such particles was assessed to be &amp;lt;0.5 μm
      in diameter. The baseline characteristics of those patients are listed in
      S1 Table. The values provided for Fig. S1 in the article’s S1 Data file
      are ng/mL values calculated from optical density (O.D.)
      measurements.&lt;/p&gt;
    </description>
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      &lt;p&gt;The dataset contains repeated values for Fig. S1A because NOX1
      concentrations were very close to the limit of detection, i.e., close to
      the O.D. of the buffer control for which we obtained a value of 0.09. The
      repeated values in the 0.07-0.16 range were interpreted as essentially
      negative results, and from these data we concluded that NOX1 was not
      detectable using this assay for most subjects. Only one normotensive and
      two hypertensive patients with microalbuminuria yielded O.D. readings
      above the 0.07-0.16 range.&lt;/p&gt;
    </description>
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