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CMS is expected to be useful in predicting prognosis\n and selecting chemotherapy regimens. However, there are still no reports\n on the relationship between the morphology and CMS. Methods This\n retrospective study included 55 subjects with T2 CRC undergoing surgical\n resection, of whom 30 had the depressed type and 25 the protruded type. In\n the classification of the CMS, we first defined cases with deficient\n mismatch repair as CMS1. And then, CMS2/3 and CMS4 were classified using\n an online classifier developed by Trinh et al. The staining intensity of\n CDX2, HTR2B, FRMD6, ZEB1, and KER and the percentage contents of CDX2,\n FRMD6, and KER are input into the classifier to obtain automatic output\n classifying the specimen as CMS2/3 or CMS4. Results According to the\n results yielded by the online classifier, of the 30 depressed-type cases,\n 15 (50%) were classified as CMS2/3 and 15 (50%) as CMS4. Of the 25\n protruded-type cases, 3 (12%) were classified as CMS1 and 22 (88%) as\n CMS2/3. All of the T2 CRCs classified as CMS4 were depressed CRCs. More\n malignant pathological findings such as lymphatic invasion were associated\n with the depressed rather than protruded T2 CRC cases.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Japan Society for the Promotion of Science","awardNumber":"KAKENHI JP19K09176","funderIdentifier":"https://ror.org/00hhkn466","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Japan Society for the Promotion of Science","awardNumber":"KAKENHI JP19H03715","funderIdentifier":"https://ror.org/00hhkn466","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Mimori, Koshi</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/04qdbg778" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Kyushu University Beppu Hospital</affiliation>
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      <creatorName nameType="Personal">Mochizuki, Kenichi</creatorName>
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      <creatorName nameType="Personal">Kudo, Shin-ei</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00p9rpe63" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Showa University Northern Yokohama Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Kato, Kazuki</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00p9rpe63" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Showa University Northern Yokohama Hospital</affiliation>
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    <creator>
      <creatorName nameType="Personal">Ogawa, Yushi</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00p9rpe63" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Showa University Northern Yokohama Hospital</affiliation>
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      <creatorName nameType="Personal">Kouyama, Yuta</creatorName>
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    <creator>
      <creatorName nameType="Personal">Takashina, Yuki</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00p9rpe63" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Showa University Northern Yokohama Hospital</affiliation>
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    <creator>
      <creatorName nameType="Personal">Ichimasa, Katsuro</creatorName>
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    <creator>
      <creatorName nameType="Personal">Tobo, Taro</creatorName>
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    <creator>
      <creatorName nameType="Personal">Toshima, Takeo</creatorName>
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    <creator>
      <creatorName nameType="Personal">Hisamatsu, Yuichi</creatorName>
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    <creator>
      <creatorName nameType="Personal">Yonemura, Yusuke</creatorName>
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    <creator>
      <creatorName nameType="Personal">Masuda, Takaaki</creatorName>
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      <creatorName nameType="Personal">Miyachi, Hideyuki</creatorName>
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    <creator>
      <creatorName nameType="Personal">Ishida, Fumio</creatorName>
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    </creator>
    <creator>
      <creatorName nameType="Personal">Nemoto, Tetsuo</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00p9rpe63" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Showa University Northern Yokohama Hospital</affiliation>
    </creator>
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  <titles>
    <title>
      Data for: Molecular and clinicopathological differences between depressed
      and protruded T2 colorectal cancer
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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      <funderName>Japan Society for the Promotion of Science</funderName>
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      <awardNumber>KAKENHI JP19K09176</awardNumber>
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    <fundingReference>
      <funderName>Japan Society for the Promotion of Science</funderName>
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  <dates>
    <date dateType="Submitted">2022-08-14T09:30:05Z</date>
    <date dateType="Issued">2022-08-18T00:00:00Z</date>
    <date dateType="Available">2022-08-18T00:00:00Z</date>
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  <language>en</language>
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  <descriptions>
    <description descriptionType="Abstract">
      Background Colorectal cancer (CRC) can be classified into four consensus
      molecular subtypes (CMS) according to genomic aberrations and gene
      expression profiles. CMS is expected to be useful in predicting prognosis
      and selecting chemotherapy regimens. However, there are still no reports
      on the relationship between the morphology and CMS. Methods This
      retrospective study included 55 subjects with T2 CRC undergoing surgical
      resection, of whom 30 had the depressed type and 25 the protruded type. In
      the classification of the CMS, we first defined cases with deficient
      mismatch repair as CMS1. And then, CMS2/3 and CMS4 were classified using
      an online classifier developed by Trinh et al. The staining intensity of
      CDX2, HTR2B, FRMD6, ZEB1, and KER and the percentage contents of CDX2,
      FRMD6, and KER are input into the classifier to obtain automatic output
      classifying the specimen as CMS2/3 or CMS4. Results According to the
      results yielded by the online classifier, of the 30 depressed-type cases,
      15 (50%) were classified as CMS2/3 and 15 (50%) as CMS4. Of the 25
      protruded-type cases, 3 (12%) were classified as CMS1 and 22 (88%) as
      CMS2/3. All of the T2 CRCs classified as CMS4 were depressed CRCs. More
      malignant pathological findings such as lymphatic invasion were associated
      with the depressed rather than protruded T2 CRC cases.
    </description>
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