{"data":{"id":"10.5061/dryad.6q573n6cp","type":"dois","attributes":{"doi":"10.5061/dryad.6q573n6cp","prefix":"10.5061","suffix":"dryad.6q573n6cp","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Saxenhofer, Moritz","nameType":"Personal","givenName":"Moritz","familyName":"Saxenhofer","affiliation":["CSL (Switzerland)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-5995-5026","nameIdentifierScheme":"ORCID"}]},{"name":"Couto, Daniel","nameType":"Personal","givenName":"Daniel","familyName":"Couto","affiliation":["CSL (Switzerland)"],"nameIdentifiers":[]},{"name":"Mena Perez, Sandra","nameType":"Personal","givenName":"Sandra","familyName":"Mena Perez","affiliation":["CSL (Switzerland)"],"nameIdentifiers":[]},{"name":"Illi, Marlies","nameType":"Personal","givenName":"Marlies","familyName":"Illi","affiliation":["CSL (Switzerland)"],"nameIdentifiers":[]},{"name":"Brodard, 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Alicia","nameType":"Personal","givenName":"Alicia","familyName":"Rovó","affiliation":["University Hospital of Bern"],"nameIdentifiers":[]},{"name":"Schaub, Alexander","nameType":"Personal","givenName":"Alexander","familyName":"Schaub","affiliation":["CSL (Switzerland)"],"nameIdentifiers":[]}],"titles":[{"title":"Plasma heme pool compartmentalization is linked to pathophysiology in sickle cell disease"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Sickle cell disease","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Heme","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Biomarkers","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2026-02-16T16:02:14Z","dateType":"Created"},{"date":"2026-02-16T16:06:26Z","dateType":"Submitted"},{"date":"2026-03-18T00:00:00Z","dateType":"Issued"},{"date":"2026-03-18T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1371/journal.pone.0343527","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["76410 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Heme toxicity plays a central role in the pathophysiology of Sickle Cell\n Disease (SCD), contributing to severe complications such as vaso-occlusion\n and acute chest syndrome. The continuous release of hemoglobin and heme\n from increased intravascular hemolysis can exceed the capacity of\n protective scavenger proteins, leading to heme accumulation in plasma.\n Interactions with various binding partners result in the formation of\n different plasma heme species and the compartmentalization of the plasma\n heme pool. In an observational biomarker study, we used novel\n bioanalytical assays to quantify plasma heme species in 36 stable-state\n SCD patients and 36 age, sex, and ethnicity-matched controls. Our results\n revealed substantially different compartmentalization of plasma heme,\n despite similar levels of total plasma heme in SCD patients (50 µmol/L)\n and controls (43 µmol/L). Using a correlation analysis across 85\n biomarkers, we examined the association of specific heme species with SCD\n pathophysiology. Hemopexin-accessible heme (HAH) emerged as a refined\n indicator of heme burden linked to pathways driving severe SCD\n complications. A strong inverse correlation was observed between HAH and\n hemopexin (R = –0.73, p \u0026lt; 0.001), suggesting that hemopexin\n deficiency contributes to elevated HAH levels. Accurate characterization\n of clinically relevant plasma heme species and understanding their effects\n on SCD pathophysiology is essential for the development of new targeted\n therapies. The data set contains individual measurement of total plamsa\n heme, the heme species and the 85 biomarkers investigated in this study\n (see description below). Full analyte names, the matrix, and units for all\n analytes are shown in the corresponding \"Variables\" table.","descriptionType":"Abstract"},{"description":"# Plasma heme pool compartmentalization is linked to pathophysiology in\n sickle cell disease Dataset DOI:\n [10.5061/dryad.6q573n6cp](https://doi.org/10.5061/dryad.6q573n6cp) ##\n Description of the data and file structure The dataset contains headers;\n missing data is represented as NA. The first two columns of the data set\n contain identifiers for individuals (\"Individuals\": consecutive\n numbers) and group identifiers (\"Group\": HC = healthy control;\n SCD = Sickle Cell Disease patient). All other columns contain biomarker\n measurements per individual (rows). The column headers indicate\n analytes that correspond to the \"Analytes\" column in the table\n below (\"Variables\"). For every analyte, this table contains the\n analyte's full name, matrix from which it was measured\n (Plasma/Serum/Blood/Urine), and units of quantification. ### Files and\n variables #### File: HemeCompartments_data.xlsx **Description:**  #####\n Variables | **Analyte** | **Analyte full name** | **Matrix** | **Unit** |\n | :--------------------- |\n :--------------------------------------------------- | :--------- |\n :----------- | | Total heme | Total plasma heme | Plasma | umol/L | | CFH\n | Cell-free hemoglobin | Plasma | umol/L | | Hpx-accessible Heme |\n Hemopexin-accessible Heme | Plasma | umol/L | | Haptoglobin (MS) |\n Haptoglobin by mass spectometry | Plasma | mg/mL | | Hp-Hb |\n Haptoglobin-hemoglobin complex | Plasma | umol/L | | Hemopexin | Hemopexin\n | Plasma | mg/mL | | Hpx-heme | Hemopexin-heme complex | Plasma | umol/L |\n | Iron | Iron | Plasma | µmol/L | | Transferrin | Transferrin | Plasma |\n g/L | | Haptoglobin (clin.) | Haptoglobin by clinical chemistry | Serum |\n g/L | | Ferritin | Ferritin | Serum | µg/L | | Bilirubin direct |\n Bilirubin direct | Plasma | µmol/L | | Bilirubin total | Bilirubin total |\n Plasma | µmol/L | | ASAT | ASAT (aspartate aminotransferase) | Plasma |\n U/L | | ALAT | ALAT (alanine aminotransferase) | Plasma | U/L | |\n Creatinine | Creatinine | Plasma | µmol/L | | LDH | LDH (lactate\n dehydrogenase) | Plasma | U/L | | D-Dimer | D-Dimer | Plasma | µg/L | |\n TAT | TAT (thrombin–antithrombin complex) | Plasma | µg/L | | INR venous |\n INR venous (international normalized ratio) | Plasma | \\[ratio] | | Quick\n venous | Quick venous | Plasma | % | | PT venous | PT venous (prothrombin\n time) | Plasma | sec | | aPTT | aPTT (activated partial thromboplastin\n time) | Plasma | sec | | Thrombin time | Thrombin time | Plasma | sec | |\n Fibrinogen Clauss man. | Fibrinogen Clauss manual | Plasma | g/L | |\n Hematocrit | Hematocrit | Blood | L/L | | Hemoglobin | Hemoglobin | Blood\n | g/L | | Leukocytes | Leukocytes | Blood | G/L | | Thrombocytes |\n Thrombocytes | Blood | G/L | | Erythrocytes | Erythrocytes | Blood | T/L |\n | MCV | MCV (mean corpuscular volume) | Blood | fL | | MCH | MCH (mean\n corpuscular hemoglobin) | Blood | pg | | MCHC | MCHC (mean corpuscular\n hemoglobin concentration) | Blood | g/L | | RDW | RDW (red cell\n distribution width) | Blood | % | | MPV | MPV (mean platelet volume) |\n Blood | fL | | IPF | IPF (immature platelet fraction) | Blood | % | |\n Normoblasts | Normoblasts | Blood | /100 Leuc.   | | Neutrophils |\n Neutrophils | Blood | G/L | | Eosinophiles | Eosinophiles | Blood | G/L |\n | Monocytes | Monocytes | Blood | G/L | | Lymphocytes | Lymphocytes |\n Blood | G/L | | Immature Granulocytes | Immature Granulocytes | Blood |\n G/L | | Reticulocytes | Reticulocytes | Blood | % | | Albumin in urine |\n Albumin in urine | Urine | mg/L | | Protein in urine | Protein in urine |\n Urine | g/L | | Creatinine in urine | Creatinine in urine | Urine | µmol/L\n | | Ang2 | Angiopoietin-2 | Plasma | pg/mL | | MCP-1 | Monocyte\n Chemoattractant Protein-1 | Plasma | pg/mL | | CD40L  | Soluble CD40\n ligand | Plasma | pg/mL | | EMMPRIN  | Extracellular matrix\n metalloproteinase inducer | Plasma | pg/mL | | GDF-15  | Growth\n Differentiation Factor 15 | Plasma | pg/mL | | ICAM-1 | Intercellular\n Adhesion Molecule-1 | Plasma | pg/mL | | CD62E | Soluble E-Selectin |\n Plasma | pg/mL | | PlGF | Placental Growth Factor | Plasma | pg/mL | | TNF\n RI | Tumor necrosis factor receptor 1 | Plasma | pg/mL | | VCAM-1 |\n Vascular cell adhesion molecule 1 | Plasma | pg/mL | | BAFF | B-cell\n activating factor | Plasma | pg/mL | | CCL20 | Macrophage Inflammatory\n Protein-3 alpha | Plasma | pg/mL | | TF\\_III | Coagulation Factor\n III/Tissue Factor | Plasma | pg/mL | | Endoglin | Endoglin | Plasma |\n pg/mL | | HGF | Hepatocyte Growth Factor | Plasma | pg/mL | | IL-1a  |\n Interleukin-1 alpha | Plasma | pg/mL | | RAGE | Soluble receptor for\n advanced glycation end-products | Plasma | pg/mL | | CD62P | Soluble\n P-Selectin  | Plasma | pg/mL | | uPAR  | Soluble urokinase plasminogen\n activator receptor | Plasma | pg/mL | | vWF-A2 | Von Willebrand factor (A2\n domain) | Plasma | pg/mL | | CD62L | Soluble L-Selectin  | Plasma | pg/mL\n | | GM-CSF | Granulocyte-macrophage colony-stimulating factor | Plasma |\n pg/mL | | IL-1b | Interleukin-1 beta | Plasma | pg/mL | | IL-2 |\n Interleukin-2 | Plasma | pg/mL | | IL-6 | Interleukin-6 | Plasma | pg/mL |\n | IL-8 | Interleukin-8 | Plasma | pg/mL | | IL-10 | Interleukin-10 |\n Plasma | pg/mL | | TNFa | Tumor necrosis factor alpha | Plasma | pg/mL | |\n VEGF | Vascular Endothelial Growth Factor | Plasma | pg/mL | | HMGB1 |\n High-Mobility-Group Box 1 | Plasma | ng/mL | | MD-2 | Myeloid\n differentiation factor-2 | Plasma | ng/mL | | Calbindin | Calbindin |\n Urine | ng/mL | | KIM-1 | Kidney Injury Molecule-1 | Urine | ng/mL | |\n TIMP-1 | Tissue inhibitor of metalloproteinases-1 | Urine | ng/mL | |\n TFF-3 | Trefoil Factor 3 | Urine | ng/mL | | GSTa | Glutathione\n S-transferase alpha | Urine | ng/mL | | FABP-1 | Fatty Acid Binding\n Protein 1 | Urine | ng/mL | | Collagen IV | Urinary type IV collagen |\n Urine | ng/mL | | NGAL | Neutrophil Gelatinase-Associated Lipocalin |\n Urine | ng/mL | | EGF | Urinary Epidermal Growth Factor | Urine | ng/mL |\n | Clusterin | Urinary Clusterin | Urine | ng/mL | | OPN | Osteopontin |\n Urine | ng/mL | | Cystatin C | Urinary cystatin C | Urine | ng/mL | | A1M\n | Urinary alpha-1 microglobulin | Urine | ng/mL | | NAG |\n N-Acetyl-β-D-glucosaminidase | Urine | U/L | | MCP1-urine | Urinary\n monocyte chemoattractant protein-1 | Urine | pg/mL | ## Human subjects\n data Consent to publish de-identified data was received from all\n participants. The data set contains biomarker concentrations without any\n demographic or clinical information.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"CSL (Switzerland)","funderIdentifier":"https://ror.org/01400tq86","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Saxenhofer, Moritz</creatorName>
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      <creatorName nameType="Personal">Couto, Daniel</creatorName>
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    </creator>
    <creator>
      <creatorName nameType="Personal">Mena Perez, Sandra</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01400tq86" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">CSL (Switzerland)</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Illi, Marlies</creatorName>
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    </creator>
    <creator>
      <creatorName nameType="Personal">Brodard, Justine</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01q9sj412" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Bern</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Njue, Linet</creatorName>
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      <creatorName nameType="Personal">Chanias, Ioannis</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01q9sj412" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Bern</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Medri, Cesare</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01q9sj412" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Bern</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tsilimidos, Gerasimos</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05a353079" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Lausanne</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Hadorn, Nicole</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01q9sj412" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Bern</affiliation>
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    <creator>
      <creatorName nameType="Personal">Chirlias, Christelle</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05a353079" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Lausanne</affiliation>
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    <creator>
      <creatorName nameType="Personal">Batista Mesquita, Ana-Patricia</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05a353079" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Lausanne</affiliation>
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      <creatorName nameType="Personal">Veuthey, Lucas</creatorName>
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      <creatorName nameType="Personal">Schnell, Anna</creatorName>
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    <creator>
      <creatorName nameType="Personal">Graeter, Stefanie</creatorName>
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      <creatorName nameType="Personal">Kato, Gregory</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01jxhxv92" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">CSL (United States)</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Adam, Jacqueline</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01400tq86" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">CSL (Switzerland)</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Merki, Ramona</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/056tb3809" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Kantonsspital Aarau</affiliation>
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    <creator>
      <creatorName nameType="Personal">Levrat, Emmanuel</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00fz8k419" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">HFR Freiburg Kantonsspital</affiliation>
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      <creatorName nameType="Personal">Samii, Kaveh</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01m1pv723" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Geneva</affiliation>
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    <creator>
      <creatorName nameType="Personal">Keiser, Mila</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01q9sj412" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Bern</affiliation>
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    <creator>
      <creatorName nameType="Personal">Bieri, Kathrin Susann</creatorName>
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      <creatorName nameType="Personal">Haynes, Alan</creatorName>
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    <creator>
      <creatorName nameType="Personal">Angelillo-Scherrer, Anne</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01q9sj412" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Bern</affiliation>
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    <creator>
      <creatorName nameType="Personal">Alberio, Lorenzo</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05a353079" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Lausanne</affiliation>
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      <creatorName nameType="Personal">Grandoni, Francesco</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05a353079" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Lausanne</affiliation>
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    <creator>
      <creatorName nameType="Personal">Gavillet, Mathilde</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05a353079" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital of Lausanne</affiliation>
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      <creatorName nameType="Personal">Gentinetta, Thomas</creatorName>
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      <creatorName nameType="Personal">Rovó, Alicia</creatorName>
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    <creator>
      <creatorName nameType="Personal">Schaub, Alexander</creatorName>
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  <titles>
    <title>
      Plasma heme pool compartmentalization is linked to pathophysiology in
      sickle cell disease
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Sickle cell disease</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Heme</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Biomarkers</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>CSL (Switzerland)</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01400tq86</funderIdentifier>
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  <dates>
    <date dateType="Created">2026-02-16T16:02:14Z</date>
    <date dateType="Submitted">2026-02-16T16:06:26Z</date>
    <date dateType="Issued">2026-03-18T00:00:00Z</date>
    <date dateType="Available">2026-03-18T00:00:00Z</date>
  </dates>
  <language>en</language>
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  <descriptions>
    <description descriptionType="Abstract">
      Heme toxicity plays a central role in the pathophysiology of Sickle Cell
      Disease (SCD), contributing to severe complications such as vaso-occlusion
      and acute chest syndrome. The continuous release of hemoglobin and heme
      from increased intravascular hemolysis can exceed the capacity of
      protective scavenger proteins, leading to heme accumulation in plasma.
      Interactions with various binding partners result in the formation of
      different plasma heme species and the compartmentalization of the plasma
      heme pool. In an observational biomarker study, we used novel
      bioanalytical assays to quantify plasma heme species in 36 stable-state
      SCD patients and 36 age, sex, and ethnicity-matched controls. Our results
      revealed substantially different compartmentalization of plasma heme,
      despite similar levels of total plasma heme in SCD patients (50 µmol/L)
      and controls (43 µmol/L). Using a correlation analysis across 85
      biomarkers, we examined the association of specific heme species with SCD
      pathophysiology. Hemopexin-accessible heme (HAH) emerged as a refined
      indicator of heme burden linked to pathways driving severe SCD
      complications. A strong inverse correlation was observed between HAH and
      hemopexin (R = –0.73, p &amp;lt; 0.001), suggesting that hemopexin
      deficiency contributes to elevated HAH levels. Accurate characterization
      of clinically relevant plasma heme species and understanding their effects
      on SCD pathophysiology is essential for the development of new targeted
      therapies. The data set contains individual measurement of total plamsa
      heme, the heme species and the 85 biomarkers investigated in this study
      (see description below). Full analyte names, the matrix, and units for all
      analytes are shown in the corresponding "Variables" table.
    </description>
    <description descriptionType="TechnicalInfo">
      # Plasma heme pool compartmentalization is linked to pathophysiology in
      sickle cell disease Dataset DOI:
      [10.5061/dryad.6q573n6cp](https://doi.org/10.5061/dryad.6q573n6cp) ##
      Description of the data and file structure The dataset contains headers;
      missing data is represented as NA. The first two columns of the data set
      contain identifiers for individuals ("Individuals": consecutive
      numbers) and group identifiers ("Group": HC = healthy control;
      SCD = Sickle Cell Disease patient). All other columns contain biomarker
      measurements per individual (rows). The column headers indicate
      analytes that correspond to the "Analytes" column in the table
      below ("Variables"). For every analyte, this table contains the
      analyte's full name, matrix from which it was measured
      (Plasma/Serum/Blood/Urine), and units of quantification. ### Files and
      variables #### File: HemeCompartments_data.xlsx **Description:**  #####
      Variables | **Analyte** | **Analyte full name** | **Matrix** | **Unit** |
      | :--------------------- |
      :--------------------------------------------------- | :--------- |
      :----------- | | Total heme | Total plasma heme | Plasma | umol/L | | CFH
      | Cell-free hemoglobin | Plasma | umol/L | | Hpx-accessible Heme |
      Hemopexin-accessible Heme | Plasma | umol/L | | Haptoglobin (MS) |
      Haptoglobin by mass spectometry | Plasma | mg/mL | | Hp-Hb |
      Haptoglobin-hemoglobin complex | Plasma | umol/L | | Hemopexin | Hemopexin
      | Plasma | mg/mL | | Hpx-heme | Hemopexin-heme complex | Plasma | umol/L |
      | Iron | Iron | Plasma | µmol/L | | Transferrin | Transferrin | Plasma |
      g/L | | Haptoglobin (clin.) | Haptoglobin by clinical chemistry | Serum |
      g/L | | Ferritin | Ferritin | Serum | µg/L | | Bilirubin direct |
      Bilirubin direct | Plasma | µmol/L | | Bilirubin total | Bilirubin total |
      Plasma | µmol/L | | ASAT | ASAT (aspartate aminotransferase) | Plasma |
      U/L | | ALAT | ALAT (alanine aminotransferase) | Plasma | U/L | |
      Creatinine | Creatinine | Plasma | µmol/L | | LDH | LDH (lactate
      dehydrogenase) | Plasma | U/L | | D-Dimer | D-Dimer | Plasma | µg/L | |
      TAT | TAT (thrombin–antithrombin complex) | Plasma | µg/L | | INR venous |
      INR venous (international normalized ratio) | Plasma | \[ratio] | | Quick
      venous | Quick venous | Plasma | % | | PT venous | PT venous (prothrombin
      time) | Plasma | sec | | aPTT | aPTT (activated partial thromboplastin
      time) | Plasma | sec | | Thrombin time | Thrombin time | Plasma | sec | |
      Fibrinogen Clauss man. | Fibrinogen Clauss manual | Plasma | g/L | |
      Hematocrit | Hematocrit | Blood | L/L | | Hemoglobin | Hemoglobin | Blood
      | g/L | | Leukocytes | Leukocytes | Blood | G/L | | Thrombocytes |
      Thrombocytes | Blood | G/L | | Erythrocytes | Erythrocytes | Blood | T/L |
      | MCV | MCV (mean corpuscular volume) | Blood | fL | | MCH | MCH (mean
      corpuscular hemoglobin) | Blood | pg | | MCHC | MCHC (mean corpuscular
      hemoglobin concentration) | Blood | g/L | | RDW | RDW (red cell
      distribution width) | Blood | % | | MPV | MPV (mean platelet volume) |
      Blood | fL | | IPF | IPF (immature platelet fraction) | Blood | % | |
      Normoblasts | Normoblasts | Blood | /100 Leuc.   | | Neutrophils |
      Neutrophils | Blood | G/L | | Eosinophiles | Eosinophiles | Blood | G/L |
      | Monocytes | Monocytes | Blood | G/L | | Lymphocytes | Lymphocytes |
      Blood | G/L | | Immature Granulocytes | Immature Granulocytes | Blood |
      G/L | | Reticulocytes | Reticulocytes | Blood | % | | Albumin in urine |
      Albumin in urine | Urine | mg/L | | Protein in urine | Protein in urine |
      Urine | g/L | | Creatinine in urine | Creatinine in urine | Urine | µmol/L
      | | Ang2 | Angiopoietin-2 | Plasma | pg/mL | | MCP-1 | Monocyte
      Chemoattractant Protein-1 | Plasma | pg/mL | | CD40L  | Soluble CD40
      ligand | Plasma | pg/mL | | EMMPRIN  | Extracellular matrix
      metalloproteinase inducer | Plasma | pg/mL | | GDF-15  | Growth
      Differentiation Factor 15 | Plasma | pg/mL | | ICAM-1 | Intercellular
      Adhesion Molecule-1 | Plasma | pg/mL | | CD62E | Soluble E-Selectin |
      Plasma | pg/mL | | PlGF | Placental Growth Factor | Plasma | pg/mL | | TNF
      RI | Tumor necrosis factor receptor 1 | Plasma | pg/mL | | VCAM-1 |
      Vascular cell adhesion molecule 1 | Plasma | pg/mL | | BAFF | B-cell
      activating factor | Plasma | pg/mL | | CCL20 | Macrophage Inflammatory
      Protein-3 alpha | Plasma | pg/mL | | TF\_III | Coagulation Factor
      III/Tissue Factor | Plasma | pg/mL | | Endoglin | Endoglin | Plasma |
      pg/mL | | HGF | Hepatocyte Growth Factor | Plasma | pg/mL | | IL-1a  |
      Interleukin-1 alpha | Plasma | pg/mL | | RAGE | Soluble receptor for
      advanced glycation end-products | Plasma | pg/mL | | CD62P | Soluble
      P-Selectin  | Plasma | pg/mL | | uPAR  | Soluble urokinase plasminogen
      activator receptor | Plasma | pg/mL | | vWF-A2 | Von Willebrand factor (A2
      domain) | Plasma | pg/mL | | CD62L | Soluble L-Selectin  | Plasma | pg/mL
      | | GM-CSF | Granulocyte-macrophage colony-stimulating factor | Plasma |
      pg/mL | | IL-1b | Interleukin-1 beta | Plasma | pg/mL | | IL-2 |
      Interleukin-2 | Plasma | pg/mL | | IL-6 | Interleukin-6 | Plasma | pg/mL |
      | IL-8 | Interleukin-8 | Plasma | pg/mL | | IL-10 | Interleukin-10 |
      Plasma | pg/mL | | TNFa | Tumor necrosis factor alpha | Plasma | pg/mL | |
      VEGF | Vascular Endothelial Growth Factor | Plasma | pg/mL | | HMGB1 |
      High-Mobility-Group Box 1 | Plasma | ng/mL | | MD-2 | Myeloid
      differentiation factor-2 | Plasma | ng/mL | | Calbindin | Calbindin |
      Urine | ng/mL | | KIM-1 | Kidney Injury Molecule-1 | Urine | ng/mL | |
      TIMP-1 | Tissue inhibitor of metalloproteinases-1 | Urine | ng/mL | |
      TFF-3 | Trefoil Factor 3 | Urine | ng/mL | | GSTa | Glutathione
      S-transferase alpha | Urine | ng/mL | | FABP-1 | Fatty Acid Binding
      Protein 1 | Urine | ng/mL | | Collagen IV | Urinary type IV collagen |
      Urine | ng/mL | | NGAL | Neutrophil Gelatinase-Associated Lipocalin |
      Urine | ng/mL | | EGF | Urinary Epidermal Growth Factor | Urine | ng/mL |
      | Clusterin | Urinary Clusterin | Urine | ng/mL | | OPN | Osteopontin |
      Urine | ng/mL | | Cystatin C | Urinary cystatin C | Urine | ng/mL | | A1M
      | Urinary alpha-1 microglobulin | Urine | ng/mL | | NAG |
      N-Acetyl-β-D-glucosaminidase | Urine | U/L | | MCP1-urine | Urinary
      monocyte chemoattractant protein-1 | Urine | pg/mL | ## Human subjects
      data Consent to publish de-identified data was received from all
      participants. The data set contains biomarker concentrations without any
      demographic or clinical information.
    </description>
  </descriptions>
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