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      The skeletal system contains a series of sophisticated cellular lineages
      arisen from the mesenchymal stem cells (MSCs) and hematopoietic stem cells
      (HSCs), that determine the homeostasis of bone and bone marrow. Here we
      reasoned that osteocyte may exert a function in regulation of these
      lineage cell specifications and tissue homeostasis. Using a mouse model of
      conditional deletion of osteocytes by the expression of diphtheria toxin
      subunit&amp;nbsp;? (DTA) in dentin matrix protein 1 (DMP1) positive
      osteocytes, we demonstrated that partial ablation of DMP1 positive
      osteocytes caused severe sarcopenia, osteoporosis and degenerative
      kyphosis, leading to shorter lifespan in these animals. Osteocytes'
      reduction altered mesenchymal lineage commitment resulting in impairment
      of osteogenesis and induction of osteoclastogensis. Single cell RNA
      sequencing further revealed that hematopoietic lineage was mobilized
      towards myeloid lineage differentiation with expanded myeloid progenitors,
      neutrophils and monocytes, while the lymphopoiesis was impaired with
      reduced B cells in the osteocyte ablation mice. The acquisition of a
      senescence-associated secretory phenotype (SASP) in both osteoprogenic and
      myeloid lineage cells was the underlying cause. Together, we showed that
      osteocytes play critical roles in regulation of lineage cell
      specifications in bone and bone marrow through mediation of senescence.
    </description>
  </descriptions>
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