{"data":{"id":"10.5061/dryad.3n5tb2rzq","type":"dois","attributes":{"doi":"10.5061/dryad.3n5tb2rzq","prefix":"10.5061","suffix":"dryad.3n5tb2rzq","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wang, Peina","nameType":"Personal","givenName":"Peina","familyName":"Wang","affiliation":["National Center for Nanoscience and Technology","Hebei Medical University","Hebei Normal University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-0776-0016","nameIdentifierScheme":"ORCID"}]},{"name":"Du, Shuailun","nameType":"Personal","givenName":"Shuailun","familyName":"Du","affiliation":["National Center for Nanoscience and Technology","University of Chinese Academy of Sciences"],"nameIdentifiers":[]},{"name":"Wu, Suying","nameType":"Personal","givenName":"Suying","familyName":"Wu","affiliation":["National Center for Nanoscience and Technology","University of Chinese Academy of Sciences"],"nameIdentifiers":[]},{"name":"Zhai, Yaqi","nameType":"Personal","givenName":"Yaqi","familyName":"Zhai","affiliation":["First Affiliated Hospital of Chinese PLA General Hospital"],"nameIdentifiers":[]},{"name":"Bai, Jiawei","nameType":"Personal","givenName":"Jiawei","familyName":"Bai","affiliation":["National Center for Nanoscience and Technology","Hebei Normal University"],"nameIdentifiers":[]},{"name":"Safdar, Ammara","nameType":"Personal","givenName":"Ammara","familyName":"Safdar","affiliation":["National Center for Nanoscience and Technology","University of Chinese Academy of Sciences"],"nameIdentifiers":[]},{"name":"Liu, Zhenyu","nameType":"Personal","givenName":"Zhenyu","familyName":"Liu","affiliation":["First Affiliated Hospital of Chinese PLA General Hospital"],"nameIdentifiers":[]},{"name":"Lu, Zefang","nameType":"Personal","givenName":"Zefang","familyName":"Lu","affiliation":["National Center for Nanoscience and Technology","University of Chinese Academy of Sciences"],"nameIdentifiers":[]},{"name":"Li, Bozhao","nameType":"Personal","givenName":"Bozhao","familyName":"Li","affiliation":["National Center for Nanoscience and Technology"],"nameIdentifiers":[]},{"name":"Cheng, Jin","nameType":"Personal","givenName":"Jin","familyName":"Cheng","affiliation":["National Center for Nanoscience and Technology","University of Chinese Academy of Sciences"],"nameIdentifiers":[]},{"name":"Song, Yuchang","nameType":"Personal","givenName":"Yuchang","familyName":"Song","affiliation":["National Center for Nanoscience and Technology"],"nameIdentifiers":[]},{"name":"Zhang, Rui","nameType":"Personal","givenName":"Rui","familyName":"Zhang","affiliation":["Peking University"],"nameIdentifiers":[]},{"name":"Li, Dandan","nameType":"Personal","givenName":"Dandan","familyName":"Li","affiliation":["Huashan Hospital"],"nameIdentifiers":[]},{"name":"Wang, Zhicheng","nameType":"Personal","givenName":"Zhicheng","familyName":"Wang","affiliation":["Huashan Hospital"],"nameIdentifiers":[]},{"name":"Zeng, Zexian","nameType":"Personal","givenName":"Zexian","familyName":"Zeng","affiliation":["Peking University"],"nameIdentifiers":[]},{"name":"Nie, Guangjun","nameType":"Personal","givenName":"Guangjun","familyName":"Nie","affiliation":["National Center for Nanoscience and Technology","University of Chinese Academy of Sciences"],"nameIdentifiers":[]},{"name":"Chang, Yan-Zhong","nameType":"Personal","givenName":"Yan-Zhong","familyName":"Chang","affiliation":["Hebei Normal University"],"nameIdentifiers":[]},{"name":"Li, Suping","nameType":"Personal","givenName":"Suping","familyName":"Li","affiliation":["National Center for Nanoscience and Technology","University of Chinese Academy of Sciences"],"nameIdentifiers":[]}],"titles":[{"title":"Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Clinical medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Nano-technology","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"Platelets","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Hemostasis","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Coagulopathy","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Hemorrhage","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2026-03-11T07:14:32Z","dateType":"Created"},{"date":"2026-03-13T00:51:33Z","dateType":"Submitted"},{"date":"2026-04-16T00:00:00Z","dateType":"Issued"},{"date":"2026-04-16T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1126/scitranslmed.aea0189","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["4510717 bytes"],"formats":[],"version":"5","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Uncontrolled hemorrhage in trauma, surgical, organ-related, and endoscopic\n settings, particularly in patients receiving antiplatelet therapy, remains\n difficult to manage clinically. Here, we introduce hPPL, a reprogrammed\n procoagulant platelet derivative generated by calcium ionophore\n A23187-induced apoptosis, enriched in surface phosphatidylserine (PS) and\n capable of driving rapid hemostasis. Retaining a protein profile akin to\n resting platelets, hPPL robustly promotes platelet activation and\n aggregation, demonstrating superior hemostatic efficacy compared with\n clinical thrombin and hemostatic materials (MPH and FIBRILLAR™) in murine\n and porcine bleeding models, even under antiplatelet treatment.\n Mechanistically, hPPL uniquely upregulates prostaglandin E synthase\n (PTGES), thereby increasing prostaglandin E2 (PGE2) production and EP3\n receptor-mediated platelet activation, which synergize with PS to amplify\n clot formation. Our findings uncover a previously unrecognized\n apoptosis-driven PTGES/PGE2/EP3 signaling axis that reinforces PS-mediated\n coagulation, establishing hPPL as a transformative, natural topical\n hemostatic agent with broad translational potential for organ-related\n bleeding and distinct advantages in managing complex endoscopic\n hemorrhages under both physiological and coagulopathic conditions.","descriptionType":"Abstract"},{"description":"# Reprogrammed apoptotic platelets drive rapid hemostasis through\n phosphatidylserine and prostaglandin E2 signaling in preclinical models\n Dataset DOI:\n [10.5061/dryad.3n5tb2rzq](https://doi.org/10.5061/dryad.3n5tb2rzq) ##\n Description of the data and file structure Proteomic analysis was\n performed to compare the protein profiles of lPPL, mPPL, hPPL, and resting\n platelets (PLTs), followed by membrane proteomic analysis between hPPL and\n PLTs. ### Files and variables #### File:\n Comparative_membrane_proteomic_analysis_of_hPPLs_and_PLTs.csv #####\n Variables * Description: * Gene Names: Gene names * pvalue(hPPL/PLT): P\n value of the comparison between hPPL and PLT. TMT data were preprocessed\n as follows: raw quantitative values of 0 were treated as missing values\n (NA), followed by log2 transformation and quantile normalization. Missing\n values were imputed using the minimum value. Differentially expressed\n proteins were identified by calculating the *t*-test p-value and\n fold-change ratio between the two groups, with ratio \u0026gt; 1.2 or ratio\n \u0026lt; 0.833 and P \u0026lt; 0.05 as the cutoff criteria. * BH adjusted\n P(hPPL/PLT): Benjamini–Hochberg adjusted P value of the comparison between\n hPPL and PLT. * ratio(hPPL/PLT):Fold-change ratio between hPPL and PLT\n #### File: Comparative_protein_profile_analysis_of_PPLs_and_PLTs.csv #####\n Variables * name: Protein ID * Description: * Gene Names: Gene names *\n Gene Ontology (biological process): * Gene Ontology (cellular component):\n * Function [CC]: * Pathway: * pvaluelPPL/PLT:P value of the comparison\n between lPPL and PLT. TMT data were preprocessed as follows: raw\n quantitative values of 0 were treated as missing values (NA), followed by\n log2 transformation and quantile normalization. Missing values were\n imputed using the minimum value. Differentially expressed proteins were\n identified by calculating the *t*-test p-value and fold-change ratio\n between the two groups, with ratio \u0026gt; 1.2 or ratio \u0026lt; 0.833 and P \u0026lt;\n 0.05 as the cutoff criteria. * BH adjusted PlPPL/PLT:Benjamini–Hochberg\n adjusted P value of the comparison between lPPL and PLT. *\n ratiolPPL/PLT:Fold-change ratio between lPPL and PLT * pvalue(mPPL/PLT):P\n value of the comparison between mPPL and PLT * BH adjusted\n P(mPPL/PLT):Benjamini–Hochberg adjusted P value of the comparison between\n mPPL and PLT. * ratio(mPPL/PLT):Fold-change ratio between mPPL and PLT *\n pvalue(hPPL/PLT):P value of the comparison between hPPL and PLT * BH\n adjusted P(hPPL/PLT):Benjamini–Hochberg adjusted P value of the comparison\n between hPPL and PLT. * ratio(hPPL/PLT):Fold-change ratio between hPPL and\n PLT * In our dataset, empty cells indicate that the corresponding\n information was not recorded or could not be obtained.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Ministry of Science and Technology of the People's Republic of China","awardNumber":"No. 2022YFA1207300","funderIdentifier":"https://ror.org/027s68j25","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Chinese Academy of Sciences","awardNumber":"XDC0290202","funderIdentifier":"https://ror.org/034t30j35","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Chinese Academy of Sciences","awardNumber":"YSBR-036","funderIdentifier":"https://ror.org/034t30j35","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"82472141","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"L248091","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.3N5TB2RZQ</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Wang, Peina</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0776-0016</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/04eymdx19" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hebei Medical University</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/004rbbw49" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hebei Normal University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Du, Shuailun</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/05qbk4x57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Chinese Academy of Sciences</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wu, Suying</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/05qbk4x57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Chinese Academy of Sciences</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhai, Yaqi</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/039713658" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">First Affiliated Hospital of Chinese PLA General Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Bai, Jiawei</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/004rbbw49" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hebei Normal University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Safdar, Ammara</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/05qbk4x57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Chinese Academy of Sciences</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liu, Zhenyu</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/039713658" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">First Affiliated Hospital of Chinese PLA General Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Lu, Zefang</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/05qbk4x57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Chinese Academy of Sciences</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Bozhao</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Cheng, Jin</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/05qbk4x57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Chinese Academy of Sciences</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Song, Yuchang</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhang, Rui</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02v51f717" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Peking University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Dandan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05201qm87" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Huashan Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wang, Zhicheng</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05201qm87" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Huashan Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zeng, Zexian</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02v51f717" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Peking University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Nie, Guangjun</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/05qbk4x57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Chinese Academy of Sciences</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Chang, Yan-Zhong</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/004rbbw49" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hebei Normal University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Suping</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f49ff35" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Center for Nanoscience and Technology</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/05qbk4x57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Chinese Academy of Sciences</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Reprogrammed apoptotic platelets drive rapid hemostasis through
      phosphatidylserine and prostaglandin E2 signaling in preclinical models
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Clinical medicine</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Nano-technology</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Platelets</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Hemostasis</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Coagulopathy</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Hemorrhage</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Ministry of Science and Technology of the People's Republic of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/027s68j25</funderIdentifier>
      <awardNumber>No. 2022YFA1207300</awardNumber>
      <awardTitle/>
    </fundingReference>
    <fundingReference>
      <funderName>Chinese Academy of Sciences</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/034t30j35</funderIdentifier>
      <awardNumber>XDC0290202</awardNumber>
      <awardTitle/>
    </fundingReference>
    <fundingReference>
      <funderName>Chinese Academy of Sciences</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/034t30j35</funderIdentifier>
      <awardNumber>YSBR-036</awardNumber>
      <awardTitle/>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82472141</awardNumber>
      <awardTitle/>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>L248091</awardNumber>
      <awardTitle/>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2026-03-11T07:14:32Z</date>
    <date dateType="Submitted">2026-03-13T00:51:33Z</date>
    <date dateType="Issued">2026-04-16T00:00:00Z</date>
    <date dateType="Available">2026-04-16T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1126/scitranslmed.aea0189</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>4510717 bytes</size>
  </sizes>
  <version>5</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      Uncontrolled hemorrhage in trauma, surgical, organ-related, and endoscopic
      settings, particularly in patients receiving antiplatelet therapy, remains
      difficult to manage clinically. Here, we introduce hPPL, a reprogrammed
      procoagulant platelet derivative generated by calcium ionophore
      A23187-induced apoptosis, enriched in surface phosphatidylserine (PS) and
      capable of driving rapid hemostasis. Retaining a protein profile akin to
      resting platelets, hPPL robustly promotes platelet activation and
      aggregation, demonstrating superior hemostatic efficacy compared with
      clinical thrombin and hemostatic materials (MPH and FIBRILLAR™) in murine
      and porcine bleeding models, even under antiplatelet treatment.
      Mechanistically, hPPL uniquely upregulates prostaglandin E synthase
      (PTGES), thereby increasing prostaglandin E2 (PGE2) production and EP3
      receptor-mediated platelet activation, which synergize with PS to amplify
      clot formation. Our findings uncover a previously unrecognized
      apoptosis-driven PTGES/PGE2/EP3 signaling axis that reinforces PS-mediated
      coagulation, establishing hPPL as a transformative, natural topical
      hemostatic agent with broad translational potential for organ-related
      bleeding and distinct advantages in managing complex endoscopic
      hemorrhages under both physiological and coagulopathic conditions.
    </description>
    <description descriptionType="TechnicalInfo">
      # Reprogrammed apoptotic platelets drive rapid hemostasis through
      phosphatidylserine and prostaglandin E2 signaling in preclinical models
      Dataset DOI:
      [10.5061/dryad.3n5tb2rzq](https://doi.org/10.5061/dryad.3n5tb2rzq) ##
      Description of the data and file structure Proteomic analysis was
      performed to compare the protein profiles of lPPL, mPPL, hPPL, and resting
      platelets (PLTs), followed by membrane proteomic analysis between hPPL and
      PLTs. ### Files and variables #### File:
      Comparative_membrane_proteomic_analysis_of_hPPLs_and_PLTs.csv #####
      Variables * Description: * Gene Names: Gene names * pvalue(hPPL/PLT): P
      value of the comparison between hPPL and PLT. TMT data were preprocessed
      as follows: raw quantitative values of 0 were treated as missing values
      (NA), followed by log2 transformation and quantile normalization. Missing
      values were imputed using the minimum value. Differentially expressed
      proteins were identified by calculating the *t*-test p-value and
      fold-change ratio between the two groups, with ratio &gt; 1.2 or ratio
      &lt; 0.833 and P &lt; 0.05 as the cutoff criteria. * BH adjusted
      P(hPPL/PLT): Benjamini–Hochberg adjusted P value of the comparison between
      hPPL and PLT. * ratio(hPPL/PLT):Fold-change ratio between hPPL and PLT
      #### File: Comparative_protein_profile_analysis_of_PPLs_and_PLTs.csv #####
      Variables * name: Protein ID * Description: * Gene Names: Gene names *
      Gene Ontology (biological process): * Gene Ontology (cellular component):
      * Function [CC]: * Pathway: * pvaluelPPL/PLT:P value of the comparison
      between lPPL and PLT. TMT data were preprocessed as follows: raw
      quantitative values of 0 were treated as missing values (NA), followed by
      log2 transformation and quantile normalization. Missing values were
      imputed using the minimum value. Differentially expressed proteins were
      identified by calculating the *t*-test p-value and fold-change ratio
      between the two groups, with ratio &gt; 1.2 or ratio &lt; 0.833 and P &lt;
      0.05 as the cutoff criteria. * BH adjusted PlPPL/PLT:Benjamini–Hochberg
      adjusted P value of the comparison between lPPL and PLT. *
      ratiolPPL/PLT:Fold-change ratio between lPPL and PLT * pvalue(mPPL/PLT):P
      value of the comparison between mPPL and PLT * BH adjusted
      P(mPPL/PLT):Benjamini–Hochberg adjusted P value of the comparison between
      mPPL and PLT. * ratio(mPPL/PLT):Fold-change ratio between mPPL and PLT *
      pvalue(hPPL/PLT):P value of the comparison between hPPL and PLT * BH
      adjusted P(hPPL/PLT):Benjamini–Hochberg adjusted P value of the comparison
      between hPPL and PLT. * ratio(hPPL/PLT):Fold-change ratio between hPPL and
      PLT * In our dataset, empty cells indicate that the corresponding
      information was not recorded or could not be obtained.
    </description>
  </descriptions>
</resource>","url":"https://datadryad.org/dataset/doi:10.5061/dryad.3n5tb2rzq","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":63,"viewsOverTime":[{"yearMonth":"2026-03","total":0},{"yearMonth":"2026-04","total":6},{"yearMonth":"2026-05","total":21},{"yearMonth":"2026-06","total":9},{"yearMonth":"2026-07","total":15},{"yearMonth":"2026-08","total":8},{"yearMonth":"2026-09","total":4}],"downloadCount":8,"downloadsOverTime":[{"yearMonth":"2026-03","total":2},{"yearMonth":"2026-04","total":1},{"yearMonth":"2026-05","total":1},{"yearMonth":"2026-06","total":3},{"yearMonth":"2026-07","total":1},{"yearMonth":"2026-08","total":0},{"yearMonth":"2026-09","total":0}],"referenceCount":0,"citationCount":1,"citationsOverTime":[{"year":"2026","total":1}],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-16T20:05:31.000Z","registered":"2026-04-16T20:05:32.000Z","published":"2026","updated":"2026-05-26T12:16:30.000Z"},"relationships":{"client":{"data":{"id":"dryad.dryad","type":"clients"}},"provider":{"data":{"id":"dryad","type":"providers"}},"media":{"data":{"id":"10.5061/dryad.3n5tb2rzq","type":"media"}},"references":{"data":[]},"citations":{"data":[{"id":"10.1126/scitranslmed.aea0189","type":"dois"}]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}