{"data":{"id":"10.5061/dryad.3n5tb2rvf","type":"dois","attributes":{"doi":"10.5061/dryad.3n5tb2rvf","prefix":"10.5061","suffix":"dryad.3n5tb2rvf","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Eagan, Tomas","nameType":"Personal","givenName":"Tomas","familyName":"Eagan","affiliation":["Haukeland University Hospital"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-8725-9960","nameIdentifierScheme":"ORCID"}]},{"name":"Nielsen, Rune","nameType":"Personal","givenName":"Rune","familyName":"Nielsen","affiliation":["University of Bergen"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2799-0430","nameIdentifierScheme":"ORCID"}]},{"name":"Haaland, Ingvild","nameType":"Personal","givenName":"Ingvild","familyName":"Haaland","affiliation":["University of Bergen"],"nameIdentifiers":[]},{"name":"Husebø, Gunnar","nameType":"Personal","givenName":"Gunnar","familyName":"Husebø","affiliation":["Haukeland University Hospital"],"nameIdentifiers":[]},{"name":"Lehmann, Sverre","nameType":"Personal","givenName":"Sverre","familyName":"Lehmann","affiliation":["Haukeland University Hospital"],"nameIdentifiers":[]},{"name":"Ward, Jon","nameType":"Personal","givenName":"Jon","familyName":"Ward","affiliation":["University of Southampton"],"nameIdentifiers":[]},{"name":"Wilson, Susan","nameType":"Personal","givenName":"Susan","familyName":"Wilson","affiliation":["University of Southampton"],"nameIdentifiers":[]}],"titles":[{"title":"Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls"}],"publisher":"Dryad","container":{},"publicationYear":2025,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"COPD"},{"subject":"Inflammation","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"bronchoscopy"},{"subject":"Biopsy","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[{"name":"Haukeland University Hospital","affiliation":[],"contributorType":"Sponsor","nameIdentifiers":[]}],"dates":[{"date":"2025-02-25T19:32:18Z","dateType":"Created"},{"date":"2025-07-13T07:18:43Z","dateType":"Submitted"},{"date":"2025-10-23T00:00:00Z","dateType":"Issued"},{"date":"2025-10-23T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.3402/ecrj.v1.26196","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.1371/journal.pone.0326267","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["147550 bytes"],"formats":[],"version":"6","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The understanding of inflammation and remodeling in the bronchial wall of\n COPD patients with varying disease severity remains incomplete. 35 healthy\n controls and 47 volunteer COPD patients underwent bronchoscopy with\n bronchoalveolar lavage (BAL) and sampling by endobronchial biopsies in\n 2014-2015 as part of the MicroCOPD Study. Biopsies were embedded in glycol\n methyl acrylate (GMA) resin and examined by immunohistochemistry and\n staining for enumeration of CD3+, CD4+, CD8+, CD20+, CD68+, EG2+, and NE+\n inflammatory cells, as well as endothelial cells (EN4) and smooth muscle\n actin (SMA). Mucus cells were stained by periodic acid-schiff (PAS) and\n toluidine blue to visualize the reticular basement membrane (RBM). The\n number of macrophages and eosinophils was higher, and vascularity\n increased in the submucosa in COPD patients compared with healthy\n controls. In healthy smokers, there were lower numbers of lymphocytes\n (CD3+, CD4+, CD8+, CD20+) than in never smokers. However, COPD patients\n with GOLD I/II had higher numbers of eosinophils and larger smooth muscle\n area compared with GOLD III/IV. COPD exacerbations the last year, blood\n eosinophils, and use of inhaled corticosteroids did not affect levels of\n inflammation or remodeling. Smoking alters inflammation in healthy\n controls, while specific patterns of macrophages, eosinophils, and\n vascularity distinguish COPD from non-COPD in bronchial biopsies.","descriptionType":"Abstract"},{"description":"# Inflammatory cells and remodeling in bronchial biopsies from COPD\n patients and controls #### Description of the data and file structure\n Observational bronchoscopy study of COPD patients and Controls with\n bronchoalveolar lavage from the middle lobe and bronchial biopsies from\n the right lower lobe. Biopsies underwent GMA embedding and were\n subsequently stained for immunohistochemistry. #### Files and variables\n **File: ToDRYAD_Oct25_2.dta** **Description:**  Stata (.dta) data file\n \"ToDRYAD_Oct25_2.dta\" Stata\n ([www.stata.com](http://www.stata.com)), which is a commercial software\n company, and use of its program require licensing. **File:\n ToDRYAD_Oct25_2.xls** **Description:** An export of the Stata file\n \"ToDRYAD_Oct25_2.dta\" (lack label values defined since excel\n does not have that), which can be opened by R or other readily available\n programs. Variables within the \"ToDRYAD_Oct25_2.dta\" and\n \"ToDRYAD_Oct25_2.xls\" files: * category - controls or COPD -\n agecat - age in three categories; 1=less than 60 yrs, 2= 60-69.99 yrs; 3=\n 70 + yrs (at the time of data collection) * smoking - smoking habits (at\n the time of data collection) - packyears_cat - pack years smoked in three\n categories for ex or current smokers * GOLD_2categories (GOLD stage for\n COPD based on FEV1 in % of predicted) - fev1*_*fvc*_*ratio - FEV1/FVC\n (forced expiratory volume in 1 second / forced vital capacity) *\n inhalsteroid - used of inhaled corticosteroids (at the time of data\n collection) - exace -  more than one serious COPD exacerbation the last 12\n months (no/yes) * CAT - CAT score (symptom score for COPD) - CD3_man -\n number of stained CD3 cells/mm2 in the biopsy * CD4_man - number of\n stained CD4 cells/mm2 in the biopsy - CD8_man - number of stained CD8\n cells/mm2 in the biopsy * CD20_man - number of stained CD20 cells/mm2 in\n the biopsy - CD68_man - number of stained CD68 cells/mm2 in the biopsy *\n EG2_man - number of eosinophil cells/mm2 in the biopsy - NOE1 - number of\n 10^6 positive pixels for neutrophils/mm2 * LamRet - thickness of basement\n membrane (lamina reticularis) in µm - PAS - Mucus in the epithelium, 10^3\n positive pixels/mm * aSMA_p - area of smooth muscle cells in % -\n EN4_fraction100- area of vascular cells in % * bal_macrophages_perc -\n Percent macrophages in bronchalveolar lavage (BAL)  [based on manual cell\n counts] - bal_lymphocytes_perc - Percent lymphocytes in bronchalveolar\n lavage (BAL)  [based on manual cell counts] * bal_neutrophils_perc -\n Percent neutrophiles in bronchalveolar lavage (BAL)  [based on manual cell\n counts] - bal_eosinophils_perc - Percent eosinophiles in bronchalveolar\n lavage (BAL)  [based on manual cell counts] * blood_leukocytes - blood\n leukocytes Total count, 10^9/L - blood_eosinophils - blood eosinophiles\n Total count, 10^9/L Note: n/a denotes either missing values (for instance\n non-successful staining/biopsy for PAS) or non-relevant value (for\n instance GOLD stage in non-COPD subjects) **File:\n syntax_for_analyses_DRYAD.do** **Description:** the Stata syntax files for\n most all calculations presented in the Tables.  Note, in the original\n paper age and packers in exact value were analyzed, but for anonymization,\n age and packyears are here given in categories. This file can be opened\n using any text editor. **File: Stata_syntax_for_analyses_in_Tables.rtf**\n **Description:** rtf version of the Stata syntax file\n \"syntax_for_analyses_DRYAD.do\" for all calculations presented in\n the Tables, available to read for those not having access to a Stata\n license. #### Code/software Stata ([www.stata.com](http://www.stata.com)),\n which is a commercial software company, and use of its program require\n licensing. ## Access information Other publicly accessible locations of\n the data: * NA Data was derived from the following sources: * NA ## Human\n subjects data Participants permitted the publication of anonymized results\n from the study. All data is anonymized (the study ID number is not\n included, and one cannot back-track from the current data file to the\n original study participants. Only the metadata used for the publication in\n PLOS One is provided here, and only on a sub-sample of all study\n participants in the MicroCOPD study. Age has been binned into categories\n for an extra layer of anonymity.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Western Norway Regional Health Authority","funderIdentifier":"https://ror.org/001212e83","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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    <creator>
      <creatorName nameType="Personal">Eagan, Tomas</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/03np4e098" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Haukeland University Hospital</affiliation>
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    <creator>
      <creatorName nameType="Personal">Haaland, Ingvild</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03zga2b32" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Bergen</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Husebø, Gunnar</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03np4e098" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Haukeland University Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Lehmann, Sverre</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03np4e098" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Haukeland University Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ward, Jon</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01ryk1543" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Southampton</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wilson, Susan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01ryk1543" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Southampton</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Inflammatory cells and remodeling in bronchial biopsies from COPD patients
      and controls
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject>COPD</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Inflammation</subject>
    <subject>bronchoscopy</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Biopsy</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Western Norway Regional Health Authority</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/001212e83</funderIdentifier>
    </fundingReference>
  </fundingReferences>
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      <contributorName>Haukeland University Hospital</contributorName>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Created">2025-02-25T19:32:18Z</date>
    <date dateType="Submitted">2025-07-13T07:18:43Z</date>
    <date dateType="Issued">2025-10-23T00:00:00Z</date>
    <date dateType="Available">2025-10-23T00:00:00Z</date>
  </dates>
  <language>en</language>
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  <descriptions>
    <description descriptionType="Abstract">
      The understanding of inflammation and remodeling in the bronchial wall of
      COPD patients with varying disease severity remains incomplete. 35 healthy
      controls and 47 volunteer COPD patients underwent bronchoscopy with
      bronchoalveolar lavage (BAL) and sampling by endobronchial biopsies in
      2014-2015 as part of the MicroCOPD Study. Biopsies were embedded in glycol
      methyl acrylate (GMA) resin and examined by immunohistochemistry and
      staining for enumeration of CD3+, CD4+, CD8+, CD20+, CD68+, EG2+, and NE+
      inflammatory cells, as well as endothelial cells (EN4) and smooth muscle
      actin (SMA). Mucus cells were stained by periodic acid-schiff (PAS) and
      toluidine blue to visualize the reticular basement membrane (RBM). The
      number of macrophages and eosinophils was higher, and vascularity
      increased in the submucosa in COPD patients compared with healthy
      controls. In healthy smokers, there were lower numbers of lymphocytes
      (CD3+, CD4+, CD8+, CD20+) than in never smokers. However, COPD patients
      with GOLD I/II had higher numbers of eosinophils and larger smooth muscle
      area compared with GOLD III/IV. COPD exacerbations the last year, blood
      eosinophils, and use of inhaled corticosteroids did not affect levels of
      inflammation or remodeling. Smoking alters inflammation in healthy
      controls, while specific patterns of macrophages, eosinophils, and
      vascularity distinguish COPD from non-COPD in bronchial biopsies.
    </description>
    <description descriptionType="TechnicalInfo">
      # Inflammatory cells and remodeling in bronchial biopsies from COPD
      patients and controls #### Description of the data and file structure
      Observational bronchoscopy study of COPD patients and Controls with
      bronchoalveolar lavage from the middle lobe and bronchial biopsies from
      the right lower lobe. Biopsies underwent GMA embedding and were
      subsequently stained for immunohistochemistry. #### Files and variables
      **File: ToDRYAD_Oct25_2.dta** **Description:**  Stata (.dta) data file
      "ToDRYAD_Oct25_2.dta" Stata
      ([www.stata.com](http://www.stata.com)), which is a commercial software
      company, and use of its program require licensing. **File:
      ToDRYAD_Oct25_2.xls** **Description:** An export of the Stata file
      "ToDRYAD_Oct25_2.dta" (lack label values defined since excel
      does not have that), which can be opened by R or other readily available
      programs. Variables within the "ToDRYAD_Oct25_2.dta" and
      "ToDRYAD_Oct25_2.xls" files: * category - controls or COPD -
      agecat - age in three categories; 1=less than 60 yrs, 2= 60-69.99 yrs; 3=
      70 + yrs (at the time of data collection) * smoking - smoking habits (at
      the time of data collection) - packyears_cat - pack years smoked in three
      categories for ex or current smokers * GOLD_2categories (GOLD stage for
      COPD based on FEV1 in % of predicted) - fev1*_*fvc*_*ratio - FEV1/FVC
      (forced expiratory volume in 1 second / forced vital capacity) *
      inhalsteroid - used of inhaled corticosteroids (at the time of data
      collection) - exace -  more than one serious COPD exacerbation the last 12
      months (no/yes) * CAT - CAT score (symptom score for COPD) - CD3_man -
      number of stained CD3 cells/mm2 in the biopsy * CD4_man - number of
      stained CD4 cells/mm2 in the biopsy - CD8_man - number of stained CD8
      cells/mm2 in the biopsy * CD20_man - number of stained CD20 cells/mm2 in
      the biopsy - CD68_man - number of stained CD68 cells/mm2 in the biopsy *
      EG2_man - number of eosinophil cells/mm2 in the biopsy - NOE1 - number of
      10^6 positive pixels for neutrophils/mm2 * LamRet - thickness of basement
      membrane (lamina reticularis) in µm - PAS - Mucus in the epithelium, 10^3
      positive pixels/mm * aSMA_p - area of smooth muscle cells in % -
      EN4_fraction100- area of vascular cells in % * bal_macrophages_perc -
      Percent macrophages in bronchalveolar lavage (BAL)  [based on manual cell
      counts] - bal_lymphocytes_perc - Percent lymphocytes in bronchalveolar
      lavage (BAL)  [based on manual cell counts] * bal_neutrophils_perc -
      Percent neutrophiles in bronchalveolar lavage (BAL)  [based on manual cell
      counts] - bal_eosinophils_perc - Percent eosinophiles in bronchalveolar
      lavage (BAL)  [based on manual cell counts] * blood_leukocytes - blood
      leukocytes Total count, 10^9/L - blood_eosinophils - blood eosinophiles
      Total count, 10^9/L Note: n/a denotes either missing values (for instance
      non-successful staining/biopsy for PAS) or non-relevant value (for
      instance GOLD stage in non-COPD subjects) **File:
      syntax_for_analyses_DRYAD.do** **Description:** the Stata syntax files for
      most all calculations presented in the Tables.  Note, in the original
      paper age and packers in exact value were analyzed, but for anonymization,
      age and packyears are here given in categories. This file can be opened
      using any text editor. **File: Stata_syntax_for_analyses_in_Tables.rtf**
      **Description:** rtf version of the Stata syntax file
      "syntax_for_analyses_DRYAD.do" for all calculations presented in
      the Tables, available to read for those not having access to a Stata
      license. #### Code/software Stata ([www.stata.com](http://www.stata.com)),
      which is a commercial software company, and use of its program require
      licensing. ## Access information Other publicly accessible locations of
      the data: * NA Data was derived from the following sources: * NA ## Human
      subjects data Participants permitted the publication of anonymized results
      from the study. All data is anonymized (the study ID number is not
      included, and one cannot back-track from the current data file to the
      original study participants. Only the metadata used for the publication in
      PLOS One is provided here, and only on a sub-sample of all study
      participants in the MicroCOPD study. Age has been binned into categories
      for an extra layer of anonymity.
    </description>
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