{"data":{"id":"10.5061/dryad.3j9kd51xs","type":"dois","attributes":{"doi":"10.5061/dryad.3j9kd51xs","prefix":"10.5061","suffix":"dryad.3j9kd51xs","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Tan, Dandan","nameType":"Personal","givenName":"Dandan","familyName":"Tan","affiliation":["Peking University First Hospital"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1899-5988","nameIdentifierScheme":"ORCID"}]},{"name":"Xiong, Hui","nameType":"Personal","givenName":"Hui","familyName":"Xiong","affiliation":["Peking University First Hospital"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4138-2992","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Data from: A novel mouse model for LAMA2-related muscular dystrophy with analysis of molecular pathogenesis and clinical phenotype"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Natural sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Natural sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"single cell RNA sequencing"},{"subject":"Lama2"},{"subject":"Muscular dystrophy"}],"contributors":[],"dates":[{"date":"2025-08-28T12:46:39Z","dateType":"Created"},{"date":"2025-09-12T14:30:26Z","dateType":"Submitted"},{"date":"2026-04-07T00:00:00Z","dateType":"Issued"},{"date":"2026-04-07T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.7554/elife.94288.4","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["14950901576 bytes"],"formats":[],"version":"3","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Our understanding of the molecular pathogenesis of LAMA2-related muscular\n dystrophy (LAMA2-MD) requires improvement. Here, we report the phenotype,\n neuropathology, and transcriptomics data (scRNA-seq and bulk RNA-seq) of a\n new Lama2 knockout mouse (dyH/dyH), which was created based on the human\n LAMA2-MD mutation hotspot region using CRISPR-Cas9. The dyH/dyH mice\n presented a severe phenotype with muscular dystrophy. Mouse brain\n scRNA-seq showed that the Lama2 gene was expressed predominantly\n and specifically in vascular and leptomeningeal fibroblasts and vascular\n smooth muscle cells, and weakly in astrocytes in wild-type mice. Laminin\n α2 expression on the cortical surface was observed with\n immunofluorescence. In dyH/dyH, Lama2 expression was decreased in those\n cell types, which might be associated with the disruption of gliovascular\n basal lamina assembly. Additionally, transcriptomic investigation of\n muscles showed 2020 differentially expressed genes, mainly associated with\n the impaired muscle cytoskeleton and development. In summary, this study\n provided potentially useful information for understanding the molecular\n pathogenesis of LAMA2-MD.","descriptionType":"Abstract"},{"description":"# Data from: A novel mouse model for LAMA2-related muscular dystrophy with\n analysis of molecular pathogenesis and clinical phenotype Dataset DOI:\n [10.5061/dryad.3j9kd51xs](10.5061/dryad.3j9kd51xs) ## Description of the\n data and file structure We have generated a novel dy^H^/dy^H^ knockout\n mouse with ΔExon 3 at the *Lama2* locus. The bulk RNA-seq data of the\n biceps femoris of the dy^H^/dy^H^ and wild-type (WT) mice have\n been deposited. RNA sequencing data of the biceps femoris obtained from\n 14-day-old mice of WT (n = 4) and dy^H^/dy^H^ (KO- LAMMA2 knockout) (n =\n 6) has been shown with files WT1, WT2, WT3, WT4, KO1, KO2, KO3, KO4, KO5,\n and KO6. The RNA samples were submitted to CapitalBio\n ([https://www.capitalbiotech.com](https://www.capitalbiotech.com)) for\n next-generation sequencing with the TruSeq RNA Exome. Paired-end\n sequencing (2 × 150 bp reads) was performed on successful RNA libraries\n using the Illumina HiSeq X-Ten platform. During the experiment,\n investigators were blinded to the samples’ information. The quality of raw\n reads was first assessed using FastQC. After filtering out low-quality\n bases and adaptors using FastP, reads were mapped to the mouse genome\n assembly GRCh38 (Mus_musculus.GRCm38.dna.toplevel.REF.fa) using Hisat2.\n Samples were subjected to quality control by examining the percentage of\n reads uniquely mapping to the genome, the percentage of reads mapping to\n known protein-coding sequences, and the number of genes with 90% base\n coverage. Gene fusions were identified by mapping reads to the mouse\n genome using StringTie. ### Files and variables #### File: WT1.zip\n **Description:** RNA sequencing data of biceps femoris obtained from a\n 14-day-old WT mouse 1 #### File: WT2.zip **Description:** RNA sequencing\n data of biceps femoris obtained from a 14-day-old WT mouse 2 #### File:\n WT3.zip **Description:** RNA sequencing data of biceps femoris obtained\n from a 14-day-old WT mouse 3 #### File: WT4.zip **Description:** RNA\n sequencing data of biceps femoris obtained from a 14-day-old WT mouse 4\n #### File: KO4.zip **Description:** RNA sequencing data of biceps femoris\n obtained from a 14-day-old KO mouse 4 #### File: KO1.zip\n **Description:** RNA sequencing data of the biceps femoris obtained from a\n 14-day-old KO mouse 1 #### File: KO2.zip **Description:** RNA sequencing\n data of the biceps femoris obtained from a 14-day-old KO mouse 2 ####\n File: KO5.zip **Description:** RNA sequencing data of biceps femoris\n obtained from a 14-day-old KO mouse 5 #### File: KO3.zip\n **Description:** RNA sequencing data of biceps femoris obtained from a\n 14-day-old KO mouse 3 #### File: KO6.zip **Description:** RNA sequencing\n data of biceps femoris obtained from a 14-day-old KO mouse 6","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Peking University First Hospital","awardNumber":"2022CR69","funderIdentifier":"https://ror.org/02z1vqm45","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"funderName":"Natural Science Foundation of Beijing Municipality","awardNumber":"7212116"},{"schemeUri":"https://ror.org","funderName":"Ministry of Science and Technology of the People's Republic of China","awardNumber":"2016YFC0901505","funderIdentifier":"https://ror.org/027s68j25","funderIdentifierType":"ROR"},{"funderName":"\n        Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric\n        Genetic Diseases\n      ","awardNumber":"BZ0317"},{"schemeUri":"https://ror.org","funderName":"First Affiliated Hospital of Nanchang University","awardNumber":"YFYPY202223","funderIdentifier":"https://ror.org/05gbwr869","funderIdentifierType":"ROR"},{"funderName":"Natural Science Foundation of Beijing Municipality","awardNumber":"7242149"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.3J9KD51XS</identifier>
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      <creatorName nameType="Personal">Tan, Dandan</creatorName>
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    </creator>
  </creators>
  <titles>
    <title>
      Data from: A novel mouse model for LAMA2-related muscular dystrophy with
      analysis of molecular pathogenesis and clinical phenotype
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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  <subjects>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Natural sciences</subject>
    <subject>single cell RNA sequencing</subject>
    <subject>Lama2</subject>
    <subject>Muscular dystrophy</subject>
  </subjects>
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    <fundingReference>
      <funderName>Peking University First Hospital</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/02z1vqm45</funderIdentifier>
      <awardNumber>2022CR69</awardNumber>
      <awardTitle/>
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    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
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      <funderName>Natural Science Foundation of Beijing Municipality</funderName>
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      <funderName>Ministry of Science and Technology of the People's Republic of China</funderName>
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      <funderName>
        Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric
        Genetic Diseases
      </funderName>
      <awardNumber>BZ0317</awardNumber>
      <awardTitle/>
    </fundingReference>
    <fundingReference>
      <funderName>First Affiliated Hospital of Nanchang University</funderName>
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      <awardNumber>YFYPY202223</awardNumber>
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      <funderName>Natural Science Foundation of Beijing Municipality</funderName>
      <awardNumber>7242149</awardNumber>
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  <dates>
    <date dateType="Created">2025-08-28T12:46:39Z</date>
    <date dateType="Submitted">2025-09-12T14:30:26Z</date>
    <date dateType="Issued">2026-04-07T00:00:00Z</date>
    <date dateType="Available">2026-04-07T00:00:00Z</date>
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  <descriptions>
    <description descriptionType="Abstract">
      Our understanding of the molecular pathogenesis of LAMA2-related muscular
      dystrophy (LAMA2-MD) requires improvement. Here, we report the phenotype,
      neuropathology, and transcriptomics data (scRNA-seq and bulk RNA-seq) of a
      new Lama2 knockout mouse (dyH/dyH), which was created based on the human
      LAMA2-MD mutation hotspot region using CRISPR-Cas9. The dyH/dyH mice
      presented a severe phenotype with muscular dystrophy. Mouse brain
      scRNA-seq showed that the&amp;nbsp;Lama2 gene was expressed predominantly
      and specifically in vascular and leptomeningeal fibroblasts and vascular
      smooth muscle cells, and weakly in astrocytes in wild-type mice. Laminin
      α2 expression on the cortical surface was observed with
      immunofluorescence. In dyH/dyH, Lama2 expression was decreased in those
      cell types, which might be associated with the disruption of gliovascular
      basal lamina assembly. Additionally, transcriptomic investigation of
      muscles showed 2020 differentially expressed genes, mainly associated with
      the impaired muscle cytoskeleton and development. In summary, this study
      provided potentially useful information for understanding the molecular
      pathogenesis of LAMA2-MD.
    </description>
    <description descriptionType="TechnicalInfo">
      # Data from: A novel mouse model for LAMA2-related muscular dystrophy with
      analysis of molecular pathogenesis and clinical phenotype Dataset DOI:
      [10.5061/dryad.3j9kd51xs](10.5061/dryad.3j9kd51xs) ## Description of the
      data and file structure We have generated a novel dy^H^/dy^H^ knockout
      mouse with ΔExon 3 at the *Lama2* locus. The bulk RNA-seq data of the
      biceps femoris of the dy^H^/dy^H^ and wild-type (WT) mice have
      been deposited. RNA sequencing data of the biceps femoris obtained from
      14-day-old mice of WT (n = 4) and dy^H^/dy^H^ (KO- LAMMA2 knockout) (n =
      6) has been shown with files WT1, WT2, WT3, WT4, KO1, KO2, KO3, KO4, KO5,
      and KO6. The RNA samples were submitted to CapitalBio
      ([https://www.capitalbiotech.com](https://www.capitalbiotech.com)) for
      next-generation sequencing with the TruSeq RNA Exome. Paired-end
      sequencing (2 × 150 bp reads) was performed on successful RNA libraries
      using the Illumina HiSeq X-Ten platform. During the experiment,
      investigators were blinded to the samples’ information. The quality of raw
      reads was first assessed using FastQC. After filtering out low-quality
      bases and adaptors using FastP, reads were mapped to the mouse genome
      assembly GRCh38 (Mus_musculus.GRCm38.dna.toplevel.REF.fa) using Hisat2.
      Samples were subjected to quality control by examining the percentage of
      reads uniquely mapping to the genome, the percentage of reads mapping to
      known protein-coding sequences, and the number of genes with 90% base
      coverage. Gene fusions were identified by mapping reads to the mouse
      genome using StringTie. ### Files and variables #### File: WT1.zip
      **Description:** RNA sequencing data of biceps femoris obtained from a
      14-day-old WT mouse 1 #### File: WT2.zip **Description:** RNA sequencing
      data of biceps femoris obtained from a 14-day-old WT mouse 2 #### File:
      WT3.zip **Description:** RNA sequencing data of biceps femoris obtained
      from a 14-day-old WT mouse 3 #### File: WT4.zip **Description:** RNA
      sequencing data of biceps femoris obtained from a 14-day-old WT mouse 4
      #### File: KO4.zip **Description:** RNA sequencing data of biceps femoris
      obtained from a 14-day-old KO mouse 4 #### File: KO1.zip
      **Description:** RNA sequencing data of the biceps femoris obtained from a
      14-day-old KO mouse 1 #### File: KO2.zip **Description:** RNA sequencing
      data of the biceps femoris obtained from a 14-day-old KO mouse 2 ####
      File: KO5.zip **Description:** RNA sequencing data of biceps femoris
      obtained from a 14-day-old KO mouse 5 #### File: KO3.zip
      **Description:** RNA sequencing data of biceps femoris obtained from a
      14-day-old KO mouse 3 #### File: KO6.zip **Description:** RNA sequencing
      data of biceps femoris obtained from a 14-day-old KO mouse 6
    </description>
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