{"data":{"id":"10.5061/dryad.2sp72","type":"dois","attributes":{"doi":"10.5061/dryad.2sp72","prefix":"10.5061","suffix":"dryad.2sp72","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Shen, Chieh-Yu","nameType":"Personal","givenName":"Chieh-Yu","familyName":"Shen","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Jann-Yuan","nameType":"Personal","givenName":"Jann-Yuan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Yu, Chia-Li","nameType":"Personal","givenName":"Chia-Li","familyName":"Yu","affiliation":[],"nameIdentifiers":[]},{"name":"Hsieh, Song-Chou","nameType":"Personal","givenName":"Song-Chou","familyName":"Hsieh","affiliation":[],"nameIdentifiers":[]},{"name":"Lee, Li-Na","nameType":"Personal","givenName":"Li-Na","familyName":"Lee","affiliation":[],"nameIdentifiers":[]},{"name":"Yu, Chong-Jen","nameType":"Personal","givenName":"Chong-Jen","familyName":"Yu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Data from: Autoantibody prevalence in active tuberculosis: reactive or pathognomonic?"}],"publisher":"Dryad","container":{},"publicationYear":2013,"subjects":[{"subject":"Immunology","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Rheumatology","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Homo Sapiens"}],"contributors":[],"dates":[{"date":"2013-11-17T11:33:05Z","dateType":"Submitted"},{"date":"2013-12-10T19:36:53Z","dateType":"Issued"},{"date":"2013-12-10T19:36:53Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1136/bmjopen-2013-002665","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["106523 bytes"],"formats":[],"version":"1","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Objectives: To evaluate the autoantibody in patients without corresponding\n symptoms, whether these autoantibody are pathognomonic or not. We\n hypothesised that autoantibody may be reactive to chronic infection, such\n as tuberculosis (TB). Design: Randomised, case–control cohort study.\n Setting: A tertiary centre in Taiwan. Participants: We randomly chose 100\n patients out of the data bank of patients with TB in a tertiary medical\n centre. All patients completed the sera sampling. We chose 100 patients\n according to autoantibody prevalence in previous literature. We also chose\n 100 medical staff as control group. Interventions: We tested anti-SSA,\n anti-SSB, anti-Sm, anti ribonucleoprotein, anti-Scl 70, anticentromere,\n anti-double-stranded DNA, anticardiolipin IgG and IgM in all patient and\n control groups. The clinical symptoms and the underlying disease were all\n recorded. Primary and secondary outcome measures: The result of sera\n antibody titre was recorded. For those with specific positive serology\n results, following examination was carried out after a 3-month anti-TB\n medication. Results: Anticardiolipin IgG titre was significantly higher in\n patients with TB than in control group. We compared the result with\n previous population study and found that anti-Scl70 is also significantly\n higher in patients with TB. The following up data in anti-Scl70 revealed\n decreased titre after treatment. No correlation between sera titre and\n clinical conditions was observed. Conclusions: In TB endemic areas, a\n significant proportion (32%) of patients with TB have elevated\n autoantibody titres, especially anticardiolipin IgG and anti-Scl-70.\n Mycobacterial studies should be performed in patients with elevated serum\n autoantibody titres but without the typical or multiple manifestations of\n autoimmune diseases. Trial registration: The study was approved by the\n Institutional Review Board of the hospital (NTUH REC: 9561707008) after\n informed consent had been obtained from the patients.","descriptionType":"Abstract"},{"description":"Primary data\n 數字resultThe ELISA result of\n autoantibodies of active TB patientsNormal population ENA\n primary resultThe ELISA result of\n autoantibodies from control 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