{"data":{"id":"10.5061/dryad.280gb5mpd","type":"dois","attributes":{"doi":"10.5061/dryad.280gb5mpd","prefix":"10.5061","suffix":"dryad.280gb5mpd","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Stelzer, Ina","nameType":"Personal","givenName":"Ina","familyName":"Stelzer","affiliation":["Stanford University School of Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9974-4661","nameIdentifierScheme":"ORCID"}]},{"name":"Ghaemi, Mohammad Sajjad","nameType":"Personal","givenName":"Mohammad Sajjad","familyName":"Ghaemi","affiliation":["Stanford University School of Medicine"],"nameIdentifiers":[]},{"name":"Han, Xiaoyuan","nameType":"Personal","givenName":"Xiaoyuan","familyName":"Han","affiliation":["Stanford University School of Medicine","Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6394-3055","nameIdentifierScheme":"ORCID"}]},{"name":"Ando, Kazuo","nameType":"Personal","givenName":"Kazuo","familyName":"Ando","affiliation":["Stanford University School of Medicine","Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1778-1344","nameIdentifierScheme":"ORCID"}]},{"name":"Hedou, Julien","nameType":"Personal","givenName":"Julien","familyName":"Hedou","affiliation":["Stanford University School of Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4721-4797","nameIdentifierScheme":"ORCID"}]},{"name":"Angst, Martin","nameType":"Personal","givenName":"Martin","familyName":"Angst","affiliation":["Stanford University School of Medicine"],"nameIdentifiers":[]},{"name":"Aghaeepour, Nima","nameType":"Personal","givenName":"Nima","familyName":"Aghaeepour","affiliation":["Stanford University School of Medicine","Stanford 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K.","familyName":"Rumer","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2713-8811","nameIdentifierScheme":"ORCID"}]},{"name":"Tsai, Eileen S.","nameType":"Personal","givenName":"Eileen S.","familyName":"Tsai","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6714-1439","nameIdentifierScheme":"ORCID"}]},{"name":"Ganio, Edward A.","nameType":"Personal","givenName":"Edward A.","familyName":"Ganio","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1088-0377","nameIdentifierScheme":"ORCID"}]},{"name":"Gaudillière, Dyani K.","nameType":"Personal","givenName":"Dyani K.","familyName":"Gaudillière","affiliation":["Korean Association of Maxillofacial Plastic and Reconstructive Surgery"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3017-5939","nameIdentifierScheme":"ORCID"}]},{"name":"Tsai, Amy S.","nameType":"Personal","givenName":"Amy S.","familyName":"Tsai","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2380-6424","nameIdentifierScheme":"ORCID"}]},{"name":"Choisy, Benjamin","nameType":"Personal","givenName":"Benjamin","familyName":"Choisy","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9873-6232","nameIdentifierScheme":"ORCID"}]},{"name":"Gaigne, Lea P.","nameType":"Personal","givenName":"Lea P.","familyName":"Gaigne","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6068-6927","nameIdentifierScheme":"ORCID"}]},{"name":"Verdonk, Franck","nameType":"Personal","givenName":"Franck","familyName":"Verdonk","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7061-5594","nameIdentifierScheme":"ORCID"}]},{"name":"Jacobsen, Danielle","nameType":"Personal","givenName":"Danielle","familyName":"Jacobsen","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2288-3858","nameIdentifierScheme":"ORCID"}]},{"name":"Gavasso, Sonia","nameType":"Personal","givenName":"Sonia","familyName":"Gavasso","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Traber, Gavin M.","nameType":"Personal","givenName":"Gavin M.","familyName":"Traber","affiliation":["Palo Alto University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3494-9196","nameIdentifierScheme":"ORCID"}]},{"name":"Ellenberger, Mathew","nameType":"Personal","givenName":"Mathew","familyName":"Ellenberger","affiliation":["Palo Alto University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-0965-9528","nameIdentifierScheme":"ORCID"}]},{"name":"Stanley, Natalie","nameType":"Personal","givenName":"Natalie","familyName":"Stanley","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Becker, Martin","nameType":"Personal","givenName":"Martin","familyName":"Becker","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4296-3481","nameIdentifierScheme":"ORCID"}]},{"name":"Culos, Anthony","nameType":"Personal","givenName":"Anthony","familyName":"Culos","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0083-6994","nameIdentifierScheme":"ORCID"}]},{"name":"Fallahzadeh, Ramin","nameType":"Personal","givenName":"Ramin","familyName":"Fallahzadeh","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Wong, Ronald J.","nameType":"Personal","givenName":"Ronald J.","familyName":"Wong","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1205-6936","nameIdentifierScheme":"ORCID"}]},{"name":"Darmstadt, Gary L.","nameType":"Personal","givenName":"Gary L.","familyName":"Darmstadt","affiliation":["Palo Alto University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7522-5824","nameIdentifierScheme":"ORCID"}]},{"name":"Druzin, Maurice L.","nameType":"Personal","givenName":"Maurice L.","familyName":"Druzin","affiliation":["Society for Maternal-Fetal Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7185-6664","nameIdentifierScheme":"ORCID"}]},{"name":"Winn, Virginia D.","nameType":"Personal","givenName":"Virginia D.","familyName":"Winn","affiliation":["Palo Alto University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1136-2907","nameIdentifierScheme":"ORCID"}]},{"name":"Gibbs, Ronald S.","nameType":"Personal","givenName":"Ronald S.","familyName":"Gibbs","affiliation":["Society for Maternal-Fetal Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-0776-6602","nameIdentifierScheme":"ORCID"}]},{"name":"Ling, Xuefeng B.","nameType":"Personal","givenName":"Xuefeng B.","familyName":"Ling","affiliation":["Palo Alto University"],"nameIdentifiers":[]},{"name":"Sylvester, Karl","nameType":"Personal","givenName":"Karl","familyName":"Sylvester","affiliation":["Palo Alto University"],"nameIdentifiers":[]},{"name":"Carvalho, Brendan","nameType":"Personal","givenName":"Brendan","familyName":"Carvalho","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Snyder, Michael P.","nameType":"Personal","givenName":"Michael P.","familyName":"Snyder","affiliation":["Palo Alto University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0784-7987","nameIdentifierScheme":"ORCID"}]},{"name":"Shaw, Gary M.","nameType":"Personal","givenName":"Gary M.","familyName":"Shaw","affiliation":["Stanford Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7438-4914","nameIdentifierScheme":"ORCID"}]},{"name":"Stevenson, David K.","nameType":"Personal","givenName":"David K.","familyName":"Stevenson","affiliation":["Stanford Medicine"],"nameIdentifiers":[]},{"name":"Contrepois, Kévin","nameType":"Personal","givenName":"Kévin","familyName":"Contrepois","affiliation":["Palo Alto University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9678-5161","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset"}],"publisher":"Dryad","container":{},"publicationYear":2021,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2021-04-24T16:47:02Z","dateType":"Submitted"},{"date":"2021-05-06T00:00:00Z","dateType":"Issued"},{"date":"2021-05-06T00:00:00Z","dateType":"Available"},{"date":"2021-09-03T00:00:00Z","dateType":"Updated"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1126/scitranslmed.abd9898","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1628725 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Estimating the time of delivery is of high clinical importance because\n pre- and postterm deviations are associated with complications for the\n mother and her offspring. However, current estimations are inaccurate. As\n pregnancy progresses toward labor, major transitions occur in fetomaternal\n immune, metabolic, and endocrine systems that culminate in birth. The\n comprehensive characterization of maternal biology that precedes labor is\n key to understanding these physiological transitions and identifying\n predictive biomarkers of delivery. Here, a longitudinal study was\n conducted in 63 women who went into labor spontaneously. More than 7000\n plasma analytes and peripheral immune cell responses were analyzed using\n untargeted mass spectrometry, aptamer-based proteomic technology, and\n single-cell mass cytometry in serial blood samples collected during the\n last 100 days of pregnancy. The high-dimensional dataset was integrated\n into a multiomic model that predicted the time to spontaneous labor [R =\n 0.85, 95% confidence interval (CI) [0.79 to 0.89], P = 1.2 × 10−40, N =\n 53, training set; R = 0.81, 95% CI [0.61 to 0.91], P = 3.9 × 10−7, N = 10,\n independent test set]. Coordinated alterations in maternal metabolome,\n proteome, and immunome marked a molecular shift from pregnancy maintenance\n to prelabor biology 2 to 4 weeks before delivery. A surge in steroid\n hormone metabolites and interleukin-1 receptor type 4 that preceded labor\n coincided with a switch from immune activation to regulation of\n inflammatory responses. Our study lays the groundwork for developing\n blood-based methods for predicting the day of labor, anchored in\n mechanisms shared in preterm and term pregnancies.","descriptionType":"Abstract"},{"description":"Blood was collected into EDTA\n tubes, kept on ice, and centrifuged (1500 x g, 20 min) at 4 ̊C within 60\n min. Separated plasma was stored at \u003csup\u003e–\u003c/sup\u003e80°C until\n further processing. The 200μL plasma samples were analyzed by the Genome\n Technology Access Center (St. Louis, MO) using a highly multiplexed,\n aptamer-based platform capturing 1310 proteins (SomaLogic, Inc., Boulder,\n CO). The assay quantifies proteins over a wide dynamic range (\u0026gt; 8\n log) using chemically modified aptamers with slow off-rate kinetics\n (SOMAmer reagents). Each SOMAmer reagent is a unique, high-affinity,\n single-strand DNA endowed with functional groups mimicking amino acid side\n chains. In brief, samples were incubated on 96-well plates with a mixture\n of SOMAmer reagents. Two sequential bead-based immobilization and washing\n steps were used to eliminate nonspecifically-bound proteins, unbound\n proteins, and unbound SOMAmer reagents from protein target-bound reagents.\n After eluting SOMAmer reagents from the target proteins, the\n fluorescently-labeled reagents were quantified on an Agilent hybridization\n array (Agilent Technologies, Santa Clara, CA). Data were normalized in 4\n specific steps and according to assay data quality control procedures\n defined in the good laboratory practice quality system of SomaLogic, Inc.\n Normalization steps control for signal intensity biases introduced by\n differential hybridization efficiencies and the overall brightness of\n plates, collection protocol artifacts, and batch effects between different\n plates.","descriptionType":"Methods"},{"description":"The data files contain the normalized plasma protein data,\n expressed as relative fluorescence units (RFU). Please refer to the ReadMe\n file ('Onset of labor proteomics') for additional\n information.","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"National Cancer Institute","awardNumber":"2RM1HG00773506","funderIdentifier":"https://ror.org/040gcmg81","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Doris Duke Charitable Foundation","awardNumber":"2018100","funderIdentifier":"https://ror.org/04n65rp89","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"March of Dimes","awardNumber":"22FY19343","funderIdentifier":"https://ror.org/04bd5p711","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"American Heart Association","awardNumber":"18IPA34170507","funderIdentifier":"https://ror.org/013kjyp64","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"The Evergreen State College","awardNumber":"STE2757/1-1","funderIdentifier":"https://ror.org/043yd1m08","funderIdentifierType":"ROR"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"Stanford Maternal and Child Health Research Institute","funderIdentifier":"https://doi.org/10.13039/100015521","funderIdentifierType":"Crossref Funder ID"},{"schemeUri":"https://ror.org","funderName":"Deutsche Forschungsgemeinschaft","awardNumber":"STE2757/1-1","funderIdentifier":"https://ror.org/018mejw64","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"R01AG058417","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"R01HL13984401","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"R21DE02772801","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"R61NS114926","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"R01HL13984403","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Bill \u0026 Melinda Gates Foundation","awardNumber":"OPP1189911","funderIdentifier":"https://ror.org/0456r8d26","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"2RM1HG00773506","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"R35GM138353","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institutes of Health","awardNumber":"R35GM137936","funderIdentifier":"https://ror.org/01cwqze88","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.280GB5MPD</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Stelzer, Ina</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-9974-4661</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ghaemi, Mohammad Sajjad</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Han, Xiaoyuan</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-6394-3055</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Ando, Kazuo</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Hedou, Julien</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-4721-4797</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Angst, Martin</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Aghaeepour, Nima</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-6117-8764</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Gaudilliere, Brice</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/011pcwc98" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford University School of Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Feyaerts, Dorien</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0795-6625</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Peterson, Laura S.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-4830-5271</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Rumer, Kristen K.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2713-8811</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tsai, Eileen S.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-6714-1439</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ganio, Edward A.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-1088-0377</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Gaudillière, Dyani K.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-3017-5939</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0036pxz38" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Korean Association of Maxillofacial Plastic and Reconstructive Surgery</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tsai, Amy S.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-2380-6424</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
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    <creator>
      <creatorName nameType="Personal">Choisy, Benjamin</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-9873-6232</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gaigne, Lea P.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-6068-6927</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Verdonk, Franck</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-7061-5594</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Jacobsen, Danielle</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-2288-3858</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gavasso, Sonia</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Traber, Gavin M.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-3494-9196</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ellenberger, Mathew</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0965-9528</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Stanley, Natalie</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Becker, Martin</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-4296-3481</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Culos, Anthony</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0083-6994</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Fallahzadeh, Ramin</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wong, Ronald J.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-1205-6936</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Darmstadt, Gary L.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7522-5824</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Druzin, Maurice L.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-7185-6664</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/001cj5727" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Society for Maternal-Fetal Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Winn, Virginia D.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-1136-2907</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
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    <creator>
      <creatorName nameType="Personal">Gibbs, Ronald S.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0776-6602</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/001cj5727" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Society for Maternal-Fetal Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ling, Xuefeng B.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Sylvester, Karl</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Carvalho, Brendan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Snyder, Michael P.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0784-7987</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Shaw, Gary M.</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-7438-4914</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Stevenson, David K.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03mtd9a03" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Stanford Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Contrepois, Kévin</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-9678-5161</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04f812k67" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Palo Alto University</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Integrated trajectories of the maternal metabolome, proteome, and immunome
      predict labor onset
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2021</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Cancer Institute</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/040gcmg81</funderIdentifier>
      <awardNumber>2RM1HG00773506</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Doris Duke Charitable Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04n65rp89</funderIdentifier>
      <awardNumber>2018100</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>March of Dimes</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04bd5p711</funderIdentifier>
      <awardNumber>22FY19343</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>American Heart Association</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/013kjyp64</funderIdentifier>
      <awardNumber>18IPA34170507</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>The Evergreen State College</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/043yd1m08</funderIdentifier>
      <awardNumber>STE2757/1-1</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Stanford Maternal and Child Health Research Institute</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID" schemeURI="https://www.crossref.org/services/funder-registry/">http://dx.doi.org/10.13039/100015521</funderIdentifier>
    </fundingReference>
    <fundingReference>
      <funderName>Deutsche Forschungsgemeinschaft</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/018mejw64</funderIdentifier>
      <awardNumber>STE2757/1-1</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>R01AG058417</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>R01HL13984401</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>R21DE02772801</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>R61NS114926</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>R01HL13984403</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Bill &amp; Melinda Gates Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/0456r8d26</funderIdentifier>
      <awardNumber>OPP1189911</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>2RM1HG00773506</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>R35GM138353</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Institutes of Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01cwqze88</funderIdentifier>
      <awardNumber>R35GM137936</awardNumber>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Submitted">2021-04-24T16:47:02Z</date>
    <date dateType="Issued">2021-05-06T00:00:00Z</date>
    <date dateType="Available">2021-05-06T00:00:00Z</date>
    <date dateType="Updated">2021-09-03T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1126/scitranslmed.abd9898</relatedIdentifier>
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  <sizes>
    <size>1628725 bytes</size>
  </sizes>
  <version>4</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      Estimating the time of delivery is of high clinical importance because
      pre- and postterm deviations are associated with complications for the
      mother and her offspring. However, current estimations are inaccurate. As
      pregnancy progresses toward labor, major transitions occur in fetomaternal
      immune, metabolic, and endocrine systems that culminate in birth. The
      comprehensive characterization of maternal biology that precedes labor is
      key to understanding these physiological transitions and identifying
      predictive biomarkers of delivery. Here, a longitudinal study was
      conducted in 63 women who went into labor spontaneously. More than 7000
      plasma analytes and peripheral immune cell responses were analyzed using
      untargeted mass spectrometry, aptamer-based proteomic technology, and
      single-cell mass cytometry in serial blood samples collected during the
      last 100 days of pregnancy. The high-dimensional dataset was integrated
      into a multiomic model that predicted the time to spontaneous labor [R =
      0.85, 95% confidence interval (CI) [0.79 to 0.89], P = 1.2 × 10−40, N =
      53, training set; R = 0.81, 95% CI [0.61 to 0.91], P = 3.9 × 10−7, N = 10,
      independent test set]. Coordinated alterations in maternal metabolome,
      proteome, and immunome marked a molecular shift from pregnancy maintenance
      to prelabor biology 2 to 4 weeks before delivery. A surge in steroid
      hormone metabolites and interleukin-1 receptor type 4 that preceded labor
      coincided with a switch from immune activation to regulation of
      inflammatory responses. Our study lays the groundwork for developing
      blood-based methods for predicting the day of labor, anchored in
      mechanisms shared in preterm and term pregnancies.
    </description>
    <description descriptionType="Methods">
      &lt;p style="border:none;"&gt;Blood was collected into EDTA
      tubes, kept on ice, and centrifuged (1500 x g, 20 min) at 4 ̊C within 60
      min. Separated plasma was stored at &lt;sup&gt;–&lt;/sup&gt;80°C until
      further processing. The 200μL plasma samples were analyzed by the Genome
      Technology Access Center (St. Louis, MO) using a highly multiplexed,
      aptamer-based platform capturing 1310 proteins (SomaLogic, Inc., Boulder,
      CO). The assay quantifies proteins over a wide dynamic range (&amp;gt; 8
      log) using chemically modified aptamers with slow off-rate kinetics
      (SOMAmer reagents). Each SOMAmer reagent is a unique, high-affinity,
      single-strand DNA endowed with functional groups mimicking amino acid side
      chains. In brief, samples were incubated on 96-well plates with a mixture
      of SOMAmer reagents. Two sequential bead-based immobilization and washing
      steps were used to eliminate nonspecifically-bound proteins, unbound
      proteins, and unbound SOMAmer reagents from protein target-bound reagents.
      After eluting SOMAmer reagents from the target proteins, the
      fluorescently-labeled reagents were quantified on an Agilent hybridization
      array (Agilent Technologies, Santa Clara, CA). Data were normalized in 4
      specific steps and according to assay data quality control procedures
      defined in the good laboratory practice quality system of SomaLogic, Inc.
      Normalization steps control for signal intensity biases introduced by
      differential hybridization efficiencies and the overall brightness of
      plates, collection protocol artifacts, and batch effects between different
      plates.&lt;/p&gt;
    </description>
    <description descriptionType="Other">
      &lt;p&gt;The data files contain the normalized plasma protein data,
      expressed as relative fluorescence units (RFU). Please refer to the ReadMe
      file ('Onset of labor proteomics') for additional
      information.&lt;/p&gt;
    </description>
  </descriptions>
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