{"data":{"id":"10.5061/dryad.2280gb5zq","type":"dois","attributes":{"doi":"10.5061/dryad.2280gb5zq","prefix":"10.5061","suffix":"dryad.2280gb5zq","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Shi, Jing","nameType":"Personal","givenName":"Jing","familyName":"Shi","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0043-8507","nameIdentifierScheme":"ORCID"}]},{"name":"Jiao, Tao","nameType":"Personal","givenName":"Tao","familyName":"Jiao","affiliation":["Peking University Cancer Hospital"],"nameIdentifiers":[]},{"name":"Guo, Qian","nameType":"Personal","givenName":"Qian","familyName":"Guo","affiliation":["Peking University Cancer Hospital"],"nameIdentifiers":[]},{"name":"Weng, Weining","nameType":"Personal","givenName":"Weining","familyName":"Weng","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Ma, Linjie","nameType":"Personal","givenName":"Linjie","familyName":"Ma","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Zhang, Qing","nameType":"Personal","givenName":"Qing","familyName":"Zhang","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Wang, Lijun","nameType":"Personal","givenName":"Lijun","familyName":"Wang","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Zhang, Jianjian","nameType":"Personal","givenName":"Jianjian","familyName":"Zhang","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Chen, Caiwei","nameType":"Personal","givenName":"Caiwei","familyName":"Chen","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Huang, Yaling","nameType":"Personal","givenName":"Yaling","familyName":"Huang","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Wang, Mingqiao","nameType":"Personal","givenName":"Mingqiao","familyName":"Wang","affiliation":["Abmart"],"nameIdentifiers":[]},{"name":"Pan, Rong","nameType":"Personal","givenName":"Rong","familyName":"Pan","affiliation":["Abmart"],"nameIdentifiers":[]},{"name":"Tang, Yanfang","nameType":"Personal","givenName":"Yanfang","familyName":"Tang","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Hu, Wenhao","nameType":"Personal","givenName":"Wenhao","familyName":"Hu","affiliation":["Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Meng, Tao","nameType":"Personal","givenName":"Tao","familyName":"Meng","affiliation":["MabCare Therapeutics \u0026 HySlink Therapeutics"],"nameIdentifiers":[]},{"name":"Liu, Shu-Hui","nameType":"Personal","givenName":"Shu-Hui","familyName":"Liu","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]},{"name":"Guo, Jun","nameType":"Personal","givenName":"Jun","familyName":"Guo","affiliation":["Peking University Cancer Hospital"],"nameIdentifiers":[]},{"name":"Kong, Yan","nameType":"Personal","givenName":"Yan","familyName":"Kong","affiliation":["Peking University Cancer Hospital"],"nameIdentifiers":[]},{"name":"Meng, Xun","nameType":"Personal","givenName":"Xun","familyName":"Meng","affiliation":["Multitude Therapeutics"],"nameIdentifiers":[]}],"titles":[{"title":"Data for: A cell surface-binding antibody atlas nominates a MUC18-directed antibody-drug conjugate for targeting melanoma"}],"publisher":"Dryad","container":{},"publicationYear":2023,"subjects":[{"subject":"Antibody array"},{"subject":"Target screening"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Melanoma","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2023-08-25T07:20:27Z","dateType":"Created"},{"date":"2023-08-25T07:58:52Z","dateType":"Submitted"},{"date":"2023-09-19T00:00:00Z","dateType":"Issued"},{"date":"2023-09-19T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1158/0008-5472.c.6931218.v1","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.1158/0008-5472.can-23-1356","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["56369441 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Recent advances in targeted therapy and immunotherapy have substantially\n improved the treatment of melanoma. However, therapeutic strategies are\n still needed for unresponsive or treatment-relapsed melanoma patients. To\n discover antibody-drug conjugate (ADC)-tractable cell surface targets for\n melanoma, we developed an atlas of melanoma cell surface binding\n antibodies (pAbs) using a proteome-scale antibody array platform (PETAL).\n Target identification of pAbs led to development of melanoma cell killing\n ADCs against LGR6, TRPM1, ASAP1, and MUC18, among others. MUC18 was\n overexpressed in both tumor cells and tumor-infiltrating blood vessels\n across major melanoma subtypes, making it a potential dual-compartment and\n universal melanoma therapeutic target. AMT-253, an MUC18-directed ADC\n based on topoisomerase I inhibitor exatecan and a self-immolative T\n moiety, had a higher therapeutic index compared to its microtubule\n inhibitor-based counterpart and favorable pharmacokinetics and\n tolerability in monkeys. AMT-253 exhibited MUC18-specific cytotoxicity\n through DNA damage and apoptosis and a strong bystander killing effect,\n leading to potent antitumor activities against melanoma cell line and\n patient-derived xenograft models. Tumor vasculature-targeting by a mouse\n MUC18-specific antibody-T1000-exatecan conjugate inhibited tumor growth in\n human melanoma xenografts. Combination therapy of AMT-253 with an\n anti-angiogenic agent generated higher efficacy than single agent in a\n mucosal melanoma model. Beyond melanoma, AMT-253 was also efficacious in a\n wide range of MUC18-expressing solid tumors. Efficient target/antibody\n discovery in combination with the T moiety-exatecan linker-payload\n exemplified here may facilitate discovery of new ADC to improve cancer\n treatment.","descriptionType":"Abstract"},{"description":"PETAL monoclonal antibody\n arrays (60,000 mAb printed on 2 x slides) were prepared as previously\n reported. Melanoma cells\n GAK, HMVII and A375 (1-2x10\u003csup\u003e7\u003c/sup\u003e) suspended in 2 ml 1x\n PBS were first labeled with DNA dye Syto-62 (ThermoFisher, S11344) at\n 1:10000 ratio for 10 minutes. Labeled cells were then incubated with PETAL\n array for 30 minutes at 37°C without shaking\n (0.5-1x10\u003csup\u003e7\u003c/sup\u003e cells per array). After a gentle washing\n step in 1x PBS buffer to remove unbound cells, the slides were scanned by\n GenePix 4200A (Modecular Device). Images were analyzed by GenePix Pro\n software (GenePix Pro, RRID:SCR_010969).","descriptionType":"Methods"},{"description":"*** # PETAL screening on melanoma cells *** An antibody array platform\n (PETAL) was used to screen overexpressed surface target on melanoma cells\n ## Description of the data and file structure The antibody arrary was\n screened against 3 different cell lines: GAK, HMVII, and A375. For each\n cell line, there was two antibody arrary slides: A1 and A2. See the\n Methods sections for details. ### The list below describes each column of\n data in the Results file: | **Block** | the block number of the feature. |\n | :---- | :------------------------------- | | **Column** | the column\n number of the feature. | | **Row** | the row number of the feature. | |\n **Name** | the name of the feature derived from the Array List (up to 40\n characters long, contained in quotation marks). | | **ID** | the unique\n identifier of the feature derived from the Array List (up to 40 characters\n long, contained in quotation marks). | | **X** | the X-coordinate in µm of\n the center of the feature-indicator associated with the feature, where\n (0,0) is the top left of the image. | | **Y** | the Y-coordinate in µm of\n the center of the feature-indicator associated with the feature, where\n (0,0) is the top left of the image. | | **Dia.** | the diameter in µm of\n the feature-indicator. | | **F635 Median** | median feature pixel\n intensity at wavelength #1 (635 nm). | | **F635 Mean** | mean feature\n pixel intensity at wavelength #1 (635 nm). | | **F635 SD** | the standard\n deviation of the feature pixel intensity at wavelength #1 (635 nm). | |\n **B635 Median** | the median feature background intensity at wavelength #1\n (635 nm). | | **B635 Mean** | the mean feature background intensity at\n wavelength #1 (635 nm). | | **B635 SD** | the standard deviation of the\n feature background intensity at wavelength #1 (635 nm). | | **% \u0026gt;\n B635 + 1 SD** | the percentage of feature pixels with intensities more\n than one standard deviation above the background pixel intensity, at\n wavelength #1 (635 nm). | | **% \u0026gt; B635 + 2 SD** | the percentage of\n feature pixels with intensities more than two standard deviations above\n the background pixel intensity, at wavelength #1 (635 nm). | | **F635 %\n Sat.** | the percentage of feature pixels at wavelength #1 that are\n saturated. | | **F532 Median** | median feature pixel intensity at\n wavelength #2 (532 nm). | | **F532 Mean** | mean feature pixel intensity\n at wavelength #2 (532 nm). | | **F532 SD** | the standard deviation of the\n feature intensity at wavelength #2 (532 nm). | | **B532 Median** | the\n median feature background intensity at wavelength #2 (532 nm). | | **B532\n Mean** | the mean feature background intensity at wavelength #2 (532 nm).\n | | **B532 SD** | the standard deviation of the feature background\n intensity at wavelength #2 (532 nm). | | **% \u0026gt; B532 + 1 SD** | the\n percentage of feature pixels with intensities more than one standard\n deviation above the background pixel intensity, at wavelength #2 (532 nm).\n | | **% \u0026gt; B532 + 2 SD** | the percentage of feature pixels with\n intensities more than two standard deviations above the background pixel\n intensity, at wavelength #2 (532 nm). | | **F532 % Sat.** | the percentage\n of feature pixels at wavelength #2 that are saturated. | | **Ratio of\n Medians** | the ratio of the median intensities of each feature for each\n wavelength, with the median background subtracted. | | **Ratio of Means**\n | the ratio of the arithmetic mean intensities of each feature for each\n wavelength, with the median background subtracted. | | **Median of\n Ratios** | the median of pixel-by-pixel ratios of pixel intensities, with\n the median background subtracted. | | **Mean of Ratios** | the geometric\n mean of the pixel-by-pixel ratios of pixel intensities, with the median\n background subtracted. | | **Ratios SD** | the geometric standard\n deviation of the pixel intensity ratios. | | **Rgn Ratio** | the\n regression ratio of every pixel in a 2-feature-diameter circle around the\n center of the feature. | | **Rgn R²** | the coefficient of determination\n for the current regression value. | | **F Pixels** | the total number of\n feature pixels. | | **B Pixels** | the total number of background pixels.\n | | **Circularity** | a metric based on the variance of the distance of\n each boundary pixel to the centroid of the feature | | **Sum of Means** |\n the sum of the arithmetic mean intensities for each wavelength, with the\n median background subtracted. | | **Log Ratio** | log (base 2) transform\n of the ratio of the medians. | | **F532 Total Intensity** | the sum of all\n pixel intensities in the feature. | | **Flags** | the type of flag\n associated with a feature. | | **Normalize** | the normalization status of\n the feature (included/not included). | | **Autoflag** | reports whether or\n not a feature has been flagged from the Flag Features dialog box. It\n applies to good and bad flags only. | ## Sharing/Access information Not\n applicable.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Ministry of Science and Technology of the People's Republic of China","funderIdentifier":"https://ror.org/027s68j25","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.2280GB5ZQ</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Shi, Jing</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0043-8507</nameIdentifier>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Jiao, Tao</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00nyxxr91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Peking University Cancer Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Guo, Qian</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00nyxxr91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Peking University Cancer Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Weng, Weining</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ma, Linjie</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhang, Qing</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wang, Lijun</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhang, Jianjian</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Chen, Caiwei</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Huang, Yaling</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wang, Mingqiao</creatorName>
      <affiliation>Abmart</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Pan, Rong</creatorName>
      <affiliation>Abmart</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tang, Yanfang</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Hu, Wenhao</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0064kty71" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Sun Yat-sen University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Meng, Tao</creatorName>
      <affiliation>MabCare Therapeutics &amp; HySlink Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liu, Shu-Hui</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Guo, Jun</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00nyxxr91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Peking University Cancer Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Kong, Yan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00nyxxr91" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Peking University Cancer Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Meng, Xun</creatorName>
      <affiliation>Multitude Therapeutics</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Data for: A cell surface-binding antibody atlas nominates a MUC18-directed
      antibody-drug conjugate for targeting melanoma
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2023</publicationYear>
  <subjects>
    <subject>Antibody array</subject>
    <subject>Target screening</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Melanoma</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Ministry of Science and Technology of the People's Republic of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/027s68j25</funderIdentifier>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2023-08-25T07:20:27Z</date>
    <date dateType="Submitted">2023-08-25T07:58:52Z</date>
    <date dateType="Issued">2023-09-19T00:00:00Z</date>
    <date dateType="Available">2023-09-19T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1158/0008-5472.c.6931218.v1</relatedIdentifier>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1158/0008-5472.can-23-1356</relatedIdentifier>
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  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      Recent advances in targeted therapy and immunotherapy have substantially
      improved the treatment of melanoma. However, therapeutic strategies are
      still needed for unresponsive or treatment-relapsed melanoma patients. To
      discover antibody-drug conjugate (ADC)-tractable cell surface targets for
      melanoma, we developed an atlas of melanoma cell surface binding
      antibodies (pAbs) using a proteome-scale antibody array platform (PETAL).
      Target identification of pAbs led to development of melanoma cell killing
      ADCs against LGR6, TRPM1, ASAP1, and MUC18, among others. MUC18 was
      overexpressed in both tumor cells and tumor-infiltrating blood vessels
      across major melanoma subtypes, making it a potential dual-compartment and
      universal melanoma therapeutic target. AMT-253, an MUC18-directed ADC
      based on topoisomerase I inhibitor exatecan and a self-immolative T
      moiety, had a higher therapeutic index compared to its microtubule
      inhibitor-based counterpart and favorable pharmacokinetics and
      tolerability in monkeys. AMT-253 exhibited MUC18-specific cytotoxicity
      through DNA damage and apoptosis and a strong bystander killing effect,
      leading to potent antitumor activities against melanoma cell line and
      patient-derived xenograft models. Tumor vasculature-targeting by a mouse
      MUC18-specific antibody-T1000-exatecan conjugate inhibited tumor growth in
      human melanoma xenografts. Combination therapy of AMT-253 with an
      anti-angiogenic agent generated higher efficacy than single agent in a
      mucosal melanoma model. Beyond melanoma, AMT-253 was also efficacious in a
      wide range of MUC18-expressing solid tumors. Efficient target/antibody
      discovery in combination with the T moiety-exatecan linker-payload
      exemplified here may facilitate discovery of new ADC to improve cancer
      treatment.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;&lt;span lang="EN-US"&gt;PETAL monoclonal antibody
      arrays (60,000 mAb printed on 2 x slides) were prepared as previously
      reported&lt;/span&gt;&lt;span lang="EN-US"&gt;. Melanoma cells
      GAK, HMVII and A375 (1-2x10&lt;sup&gt;7&lt;/sup&gt;) suspended in 2 ml 1x
      PBS were first labeled with DNA dye Syto-62 (ThermoFisher, S11344) at
      1:10000 ratio for 10 minutes. Labeled cells were then incubated with PETAL
      array for 30 minutes at 37&lt;/span&gt;&lt;span
      lang="EN-US"&gt;°C &lt;/span&gt;&lt;span
      lang="EN-US"&gt;without shaking
      (0.5-1x10&lt;sup&gt;7&lt;/sup&gt; cells per array). After a gentle washing
      step in 1x PBS buffer to remove unbound cells, the slides were scanned by
      GenePix 4200A (Modecular Device). Images were analyzed by GenePix Pro
      software (GenePix Pro, RRID:SCR_010969). &lt;/span&gt;&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      *** # PETAL screening on melanoma cells *** An antibody array platform
      (PETAL) was used to screen overexpressed surface target on melanoma cells
      ## Description of the data and file structure The antibody arrary was
      screened against 3 different cell lines: GAK, HMVII, and A375. For each
      cell line, there was two antibody arrary slides: A1 and A2. See the
      Methods sections for details. ### The list below describes each column of
      data in the Results file: | **Block** | the block number of the feature. |
      | :---- | :------------------------------- | | **Column** | the column
      number of the feature. | | **Row** | the row number of the feature. | |
      **Name** | the name of the feature derived from the Array List (up to 40
      characters long, contained in quotation marks). | | **ID** | the unique
      identifier of the feature derived from the Array List (up to 40 characters
      long, contained in quotation marks). | | **X** | the X-coordinate in µm of
      the center of the feature-indicator associated with the feature, where
      (0,0) is the top left of the image. | | **Y** | the Y-coordinate in µm of
      the center of the feature-indicator associated with the feature, where
      (0,0) is the top left of the image. | | **Dia.** | the diameter in µm of
      the feature-indicator. | | **F635 Median** | median feature pixel
      intensity at wavelength #1 (635 nm). | | **F635 Mean** | mean feature
      pixel intensity at wavelength #1 (635 nm). | | **F635 SD** | the standard
      deviation of the feature pixel intensity at wavelength #1 (635 nm). | |
      **B635 Median** | the median feature background intensity at wavelength #1
      (635 nm). | | **B635 Mean** | the mean feature background intensity at
      wavelength #1 (635 nm). | | **B635 SD** | the standard deviation of the
      feature background intensity at wavelength #1 (635 nm). | | **% &amp;gt;
      B635 + 1 SD** | the percentage of feature pixels with intensities more
      than one standard deviation above the background pixel intensity, at
      wavelength #1 (635 nm). | | **% &amp;gt; B635 + 2 SD** | the percentage of
      feature pixels with intensities more than two standard deviations above
      the background pixel intensity, at wavelength #1 (635 nm). | | **F635 %
      Sat.** | the percentage of feature pixels at wavelength #1 that are
      saturated. | | **F532 Median** | median feature pixel intensity at
      wavelength #2 (532 nm). | | **F532 Mean** | mean feature pixel intensity
      at wavelength #2 (532 nm). | | **F532 SD** | the standard deviation of the
      feature intensity at wavelength #2 (532 nm). | | **B532 Median** | the
      median feature background intensity at wavelength #2 (532 nm). | | **B532
      Mean** | the mean feature background intensity at wavelength #2 (532 nm).
      | | **B532 SD** | the standard deviation of the feature background
      intensity at wavelength #2 (532 nm). | | **% &amp;gt; B532 + 1 SD** | the
      percentage of feature pixels with intensities more than one standard
      deviation above the background pixel intensity, at wavelength #2 (532 nm).
      | | **% &amp;gt; B532 + 2 SD** | the percentage of feature pixels with
      intensities more than two standard deviations above the background pixel
      intensity, at wavelength #2 (532 nm). | | **F532 % Sat.** | the percentage
      of feature pixels at wavelength #2 that are saturated. | | **Ratio of
      Medians** | the ratio of the median intensities of each feature for each
      wavelength, with the median background subtracted. | | **Ratio of Means**
      | the ratio of the arithmetic mean intensities of each feature for each
      wavelength, with the median background subtracted. | | **Median of
      Ratios** | the median of pixel-by-pixel ratios of pixel intensities, with
      the median background subtracted. | | **Mean of Ratios** | the geometric
      mean of the pixel-by-pixel ratios of pixel intensities, with the median
      background subtracted. | | **Ratios SD** | the geometric standard
      deviation of the pixel intensity ratios. | | **Rgn Ratio** | the
      regression ratio of every pixel in a 2-feature-diameter circle around the
      center of the feature. | | **Rgn R²** | the coefficient of determination
      for the current regression value. | | **F Pixels** | the total number of
      feature pixels. | | **B Pixels** | the total number of background pixels.
      | | **Circularity** | a metric based on the variance of the distance of
      each boundary pixel to the centroid of the feature | | **Sum of Means** |
      the sum of the arithmetic mean intensities for each wavelength, with the
      median background subtracted. | | **Log Ratio** | log (base 2) transform
      of the ratio of the medians. | | **F532 Total Intensity** | the sum of all
      pixel intensities in the feature. | | **Flags** | the type of flag
      associated with a feature. | | **Normalize** | the normalization status of
      the feature (included/not included). | | **Autoflag** | reports whether or
      not a feature has been flagged from the Flag Features dialog box. It
      applies to good and bad flags only. | ## Sharing/Access information Not
      applicable.
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