{"data":{"id":"10.5061/dryad.1zcrjdg6c","type":"dois","attributes":{"doi":"10.5061/dryad.1zcrjdg6c","prefix":"10.5061","suffix":"dryad.1zcrjdg6c","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Zhu, Haiying","nameType":"Personal","givenName":"Haiying","familyName":"Zhu","affiliation":["Zhejiang University","Hangzhou City University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0009-4437-0998","nameIdentifierScheme":"ORCID"}]},{"name":"Lin, Yushen","nameType":"Personal","givenName":"Yushen","familyName":"Lin","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"Jiang, Li","nameType":"Personal","givenName":"Li","familyName":"Jiang","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"Zhao, Wenyi","nameType":"Personal","givenName":"Wenyi","familyName":"Zhao","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"Lu, Bin","nameType":"Personal","givenName":"Bin","familyName":"Lu","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"Zhou, Zhan","nameType":"Personal","givenName":"Zhan","familyName":"Zhou","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"He, Qiaojun","nameType":"Personal","givenName":"Qiaojun","familyName":"He","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"Yang, Bo","nameType":"Personal","givenName":"Bo","familyName":"Yang","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"Tomek, Petr","nameType":"Personal","givenName":"Petr","familyName":"Tomek","affiliation":["University of Auckland"],"nameIdentifiers":[]},{"name":"Zhao, Wenbin","nameType":"Personal","givenName":"Wenbin","familyName":"Zhao","affiliation":["Zhejiang University"],"nameIdentifiers":[]},{"name":"Cao, Ji","nameType":"Personal","givenName":"Ji","familyName":"Cao","affiliation":["Zhejiang University"],"nameIdentifiers":[]}],"titles":[{"title":"scRNA-seq data from: DJ-1 inhibition reshapes tumor microenvironment and potentiates immune checkpoint inhibitors"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer immunotherapy","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Antibody therapy","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"DJ-1"}],"contributors":[],"dates":[{"date":"2025-11-10T01:12:50Z","dateType":"Created"},{"date":"2026-03-05T08:13:08Z","dateType":"Submitted"},{"date":"2026-03-06T00:00:00Z","dateType":"Issued"},{"date":"2026-03-06T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1126/sciadv.ady7556","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["251435493857 bytes"],"formats":[],"version":"5","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This dataset contains raw single-cell RNA sequencing data generated from\n tumor-infiltrating CD45⁺ immune cells in murine cancer models to\n investigate the role of DJ-1 (PARK7) in modulating anti-tumor immunity. In\n the associated study, genetic ablation of DJ-1 enhanced the efficacy of\n immune checkpoint blockade by indirectly activating T cells through\n macrophage reprogramming. Loss of DJ-1 increased reactive oxygen species\n (ROS) levels in macrophages and promoting differentiation into Cxcl9⁺\n immune-stimulatory phenotypes while reducing Spp1⁺ immune-suppressive\n subsets. Here, we deposited additional raw sequencing reads in FASTQ\n format from sorted CD45⁺ cells (DJ-1 knockout and wild-type\n conditions).  A detailed description of experimental procedures\n and analysis workflows can be found in the associated publication.","descriptionType":"Abstract"},{"description":"# scRNA-seq data from: DJ-1 inhibition reshapes tumor microenvironment and\n potentiates immune checkpoint inhibitors Dataset DOI:\n [10.5061/dryad.1zcrjdg6c](https://doi.org/10.5061/dryad.1zcrjdg6c) ##\n Description of the data and file structure This dataset supplements the\n manuscript titled “DJ-1 Inhibition Reshapes Tumor Microenvironment and\n Potentiates Immune Checkpoint Inhibitors”. We performed single‑cell RNA\n sequencing of tumor‑infiltrating CD45⁺ immune cells to characterize\n transcriptional changes in T cell and myeloid populations following DJ‑1\n knockout. All raw sequencing reads are deposited in FASTQ format. The\n *KO-antibody-T.fq.gz* and *WT-antibody-T.fq.gz* datasets correspond to the\n T cell–related TRC analyses in Figure 3, whereas the *KO1.fq.gz*,\n *KO2.fq.gz*, *WT1.fq.gz*, and *WT2.fq.gz* datasets correspond to the\n myeloid cell analyses in Figures 4 and 5. Detailed experimental and\n analytical methods are provided in the associated manuscript. ### Files\n and variables These are the raw reads of the mice dataset (Dryad): *\n KO-antibody-T_R1.fq.gz * KO-antibody-T_R2.fq.gz * WT-antibody-T_R1.fq.gz *\n WT-antibody-T_R2.fq.gz * KO1_R1.fq.gz * KO1_R2.fq.gz * KO2_R1.fq.gz *\n KO2_R2.fq.gz * WT1_R1.fq.gz * WT1_R2.fq.gz * WT2_R1.fq.gz * WT2_R2.fq.gz\n ## Code/software The construction of the second-generation sequencing\n library for gene expression analysis was performed by Singleron Biotech.\n The raw barcode, feature, and matrix files was performed R (v4.2.1) and\n processed with Seurat (v4.3.0), such as DESeq2, ggplot2, pheatmap,\n clusterProfiler and Seurat. No custom software was generated for the\n purpose of this research. ##","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","awardTitle":"\n        Outstanding Youth Science Fund of Zhejiang Provincial Natural Science\n        Foundation\n      ","funderName":"Zhejiang Provincial Natural Science Foundation","awardNumber":"LR22H310002","funderIdentifier":"https://ror.org/04aqat463","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","awardTitle":"Fundamental Research Funds for the Central Universities","funderName":"Zhejiang University","awardNumber":"No. 226-2025-00009","funderIdentifier":"https://ror.org/00a2xv884","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"82504856","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.1ZCRJDG6C</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Zhu, Haiying</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0009-0009-4437-0998</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/01wck0s05" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hangzhou City University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Lin, Yushen</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Jiang, Li</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhao, Wenyi</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Lu, Bin</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhou, Zhan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">He, Qiaojun</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Yang, Bo</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tomek, Petr</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03b94tp07" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Auckland</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhao, Wenbin</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Cao, Ji</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00a2xv884" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Zhejiang University</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      scRNA-seq data from: DJ-1 inhibition reshapes tumor microenvironment and
      potentiates immune checkpoint inhibitors
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Cancer immunotherapy</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Antibody therapy</subject>
    <subject>DJ-1</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Zhejiang Provincial Natural Science Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04aqat463</funderIdentifier>
      <awardNumber>LR22H310002</awardNumber>
      <awardTitle>
        Outstanding Youth Science Fund of Zhejiang Provincial Natural Science
        Foundation
      </awardTitle>
    </fundingReference>
    <fundingReference>
      <funderName>Zhejiang University</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/00a2xv884</funderIdentifier>
      <awardNumber>No. 226-2025-00009</awardNumber>
      <awardTitle>Fundamental Research Funds for the Central Universities</awardTitle>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82504856</awardNumber>
      <awardTitle/>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2025-11-10T01:12:50Z</date>
    <date dateType="Submitted">2026-03-05T08:13:08Z</date>
    <date dateType="Issued">2026-03-06T00:00:00Z</date>
    <date dateType="Available">2026-03-06T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1126/sciadv.ady7556</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>251435493857 bytes</size>
  </sizes>
  <version>5</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      This dataset contains raw single-cell RNA sequencing data generated from
      tumor-infiltrating CD45⁺ immune cells in murine cancer models to
      investigate the role of DJ-1 (PARK7) in modulating anti-tumor immunity. In
      the associated study, genetic ablation of DJ-1 enhanced the efficacy of
      immune checkpoint blockade by indirectly activating T cells through
      macrophage reprogramming. Loss of DJ-1 increased reactive oxygen species
      (ROS) levels in macrophages and promoting differentiation into Cxcl9⁺
      immune-stimulatory phenotypes while reducing Spp1⁺ immune-suppressive
      subsets. Here, we deposited additional raw sequencing reads in FASTQ
      format from sorted CD45⁺ cells (DJ-1 knockout and wild-type
      conditions).&amp;nbsp; A detailed description of experimental procedures
      and analysis workflows can be found in the associated publication.
    </description>
    <description descriptionType="TechnicalInfo">
      # scRNA-seq data from: DJ-1 inhibition reshapes tumor microenvironment and
      potentiates immune checkpoint inhibitors Dataset DOI:
      [10.5061/dryad.1zcrjdg6c](https://doi.org/10.5061/dryad.1zcrjdg6c) ##
      Description of the data and file structure This dataset supplements the
      manuscript titled “DJ-1 Inhibition Reshapes Tumor Microenvironment and
      Potentiates Immune Checkpoint Inhibitors”. We performed single‑cell RNA
      sequencing of tumor‑infiltrating CD45⁺ immune cells to characterize
      transcriptional changes in T cell and myeloid populations following DJ‑1
      knockout. All raw sequencing reads are deposited in FASTQ format. The
      *KO-antibody-T.fq.gz* and *WT-antibody-T.fq.gz* datasets correspond to the
      T cell–related TRC analyses in Figure 3, whereas the *KO1.fq.gz*,
      *KO2.fq.gz*, *WT1.fq.gz*, and *WT2.fq.gz* datasets correspond to the
      myeloid cell analyses in Figures 4 and 5. Detailed experimental and
      analytical methods are provided in the associated manuscript. ### Files
      and variables These are the raw reads of the mice dataset (Dryad): *
      KO-antibody-T_R1.fq.gz * KO-antibody-T_R2.fq.gz * WT-antibody-T_R1.fq.gz *
      WT-antibody-T_R2.fq.gz * KO1_R1.fq.gz * KO1_R2.fq.gz * KO2_R1.fq.gz *
      KO2_R2.fq.gz * WT1_R1.fq.gz * WT1_R2.fq.gz * WT2_R1.fq.gz * WT2_R2.fq.gz
      ## Code/software The construction of the second-generation sequencing
      library for gene expression analysis was performed by Singleron Biotech.
      The raw barcode, feature, and matrix files was performed R (v4.2.1) and
      processed with Seurat (v4.3.0), such as DESeq2, ggplot2, pheatmap,
      clusterProfiler and Seurat. No custom software was generated for the
      purpose of this research. ##
    </description>
  </descriptions>
</resource>","url":"https://datadryad.org/dataset/doi:10.5061/dryad.1zcrjdg6c","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":43,"viewsOverTime":[{"yearMonth":"2026-03","total":15},{"yearMonth":"2026-04","total":5},{"yearMonth":"2026-05","total":3},{"yearMonth":"2026-06","total":4},{"yearMonth":"2026-07","total":1},{"yearMonth":"2026-08","total":7},{"yearMonth":"2026-09","total":8}],"downloadCount":1,"downloadsOverTime":[{"yearMonth":"2026-03","total":1},{"yearMonth":"2026-04","total":0},{"yearMonth":"2026-05","total":0},{"yearMonth":"2026-06","total":0},{"yearMonth":"2026-07","total":0},{"yearMonth":"2026-08","total":0},{"yearMonth":"2026-09","total":0}],"referenceCount":0,"citationCount":1,"citationsOverTime":[{"year":"2026","total":1}],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-03-06T18:08:50.000Z","registered":"2026-03-06T18:08:51.000Z","published":"2026","updated":"2026-04-10T10:57:39.000Z"},"relationships":{"client":{"data":{"id":"dryad.dryad","type":"clients"}},"provider":{"data":{"id":"dryad","type":"providers"}},"media":{"data":{"id":"10.5061/dryad.1zcrjdg6c","type":"media"}},"references":{"data":[]},"citations":{"data":[{"id":"10.1126/sciadv.ady7556","type":"dois"}]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}