{"data":{"id":"10.5061/dryad.1vhhmgr60","type":"dois","attributes":{"doi":"10.5061/dryad.1vhhmgr60","prefix":"10.5061","suffix":"dryad.1vhhmgr60","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Feng, Ruijia","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0004-8494-0071","nameIdentifierScheme":"ORCID"}]},{"name":"Feng, Weiqi","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Luo, Yuyan","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Peng, Guiyan","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Yang, Wenchao","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Long, Ting","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Cen, Meifeng","nameType":"Personal","affiliation":["Sun Yat-sen Memorial Hospital"],"nameIdentifiers":[]},{"name":"Liu, Yunchong","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Wei, Litai","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Huang, Kan","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Li, Zilun","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]},{"name":"Chang, Guangqi","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"nameIdentifiers":[]}],"titles":[{"title":"Data from: Alternate day fasting attenuates metabolic dysfunction-associated arterial thrombotic risk via increasing indole-3-propionic acid"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"Cardiovascular therapy","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Gut bacteria","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Metabolism","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[{"name":"Feng, Ruijia","nameType":"Personal","affiliation":["The First Affiliated Hospital, Sun Yat-sen University"],"contributorType":"ContactPerson","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0004-8494-0071","nameIdentifierScheme":"ORCID"}]}],"dates":[{"date":"2025-04-02T04:07:16Z","dateType":"Created"},{"date":"2025-09-03T02:17:22Z","dateType":"Submitted"},{"date":"2026-09-02T00:00:00Z","dateType":"Issued"},{"date":"2026-09-02T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1161/circ.150.suppl_1.4141327","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.1016/j.celrep.2026.118032","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["4472970 bytes"],"formats":[],"version":"6","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Metabolic dysfunction-associated arterial thrombosis poses a major health\n challenge worldwide. Emerging studies have highlighted the metabolic\n benefits of alternate day fasting (ADF), providing insight into its\n potential therapeutic effect on thrombotic events. Here, we show that ADF\n attenuates platelet hyperreactivity and thrombotic tendency in obese mice\n by reshaping the gut microbiota.Further metabolomic analysis identify\n indole-3-propionic acid (IPA), a gut microbial derived metabolite, as key\n contributor of thrombosis-ameliorating effects of ADF. Mechanistically,\n IPA preserves the intraplatelet Rho-GTPase cycle homeostasis and\n suppresses downstream signaling pathways, thus inhibiting the platelet\n activation cascade and alleviating thrombus formation without affecting\n hemostasis in vivo. Moreover, patients with metabolic\n disturbance-associated arterial thrombosis exhibit significantly lower\n plasma IPA levels, which demonstrates strong predictive value for\n thrombotic risk and inversely correlates with platelet reactivity. Here,\n we show ADF’s protective role in metabolic dysfunction-associated\n thrombogenesis and validate IPA as a safe, effective antithrombotic agent\n with novel mechanistic insights.","descriptionType":"Abstract"},{"description":"# Data from: Alternate day fasting attenuates metabolic\n dysfunction-associated arterial thrombotic risk via increasing\n indole-3-propionic acid Dataset DOI:\n [10.5061/dryad.1vhhmgr60](https://doi.org/10.5061/dryad.1vhhmgr60) ##\n Description of the data and file structure 1. For the dietary intervention\n study, male C57BL/6J mice (6-week-old) were randomly divided into 4 groups\n : (1) Control (Ctrl): standard experimental diet for 12 weeks; (2) High\n fat diet (HFD): diet consisting of 60 % fat for 12 weeks; (3) ADF: HFD for\n 6 weeks, followed by a feeding regimen of every other day with HFD for the\n subsequent 6 weeks; (4) Paired feeding (PF): HFD for 6 weeks, followed by\n feeding with equivalent daily food intake to the ADF group with HFD for\n the next 6 weeks. The plasma samples were collected for metabolomics\n analysis and cecal feces were collected for metagenomic sequencing.  2.\n For fecal microbes transplantation (FMT) study, the male C57BL/6J mice\n received antibiotic cocktail to remove the original gut microbiota. Then,\n the mice were given fecal microbiota suspension from above HFD and ADF\n groups for 2 weeks. The cecal feces were collected for metagenomic\n sequencing.  3. Mice washed platelet samples were maintained in a resting\n state or stimulated with thrombin for 3 min with or without IPA\n preincubation. Protein samples were extracted for further phosphorylated\n proteome analysis.  ### Files and variables #### File:\n Plasma_metabolomic.csv **Description:** Plasma metabolites levels in\n different samples ##### Variables * Index: Metabolites index labelled\n by metware company * Compounds: Metabolites name * Class I: Primary\n category * Class II: Secondary category * Molecular weight (Da): Molecular\n weight * Formula: Formula * CD-1: sample 1 from control group * CD-2:\n sample 2 from control group * CD-3: sample 3 from control group *\n CD-4: sample 4 from control group * CD-5: sample 5 from control group *\n HFD-1: sample 1 from high fat diet group * HFD-2: sample 2 from high fat\n diet group * HFD-3: sample 3 from high fat diet group * HFD-4: sample 4\n from high fat diet group * HFD-5: sample 5 from high fat diet group *\n ADF-1: sample 1 from alternate day fasting group * ADF-2: sample 2\n from alternate day fasting group * ADF-3: sample 3 from alternate day\n fasting group * ADF-4: sample 4 from alternate day fasting group *\n ADF-5: sample 5 from alternate day fasting group * PF-1: sample 1\n from pair feeding group * PF-2: sample 2 from pair feeding group *\n PF-3: sample 3 from pair feeding group * PF-4: sample 4 from pair feeding\n group #### File: Fecal_metagenomic_genus_level.csv **Description:** Gut\n microbiota genus levels in different samples ##### Variables * Index:\n genus name * CD-1: sample 1 from control group * CD-2: sample 2\n from control group * CD-3: sample 3 from control group * CD-4: sample 4\n from control group * CD-5: sample 5 from control group * HFD-1: sample 1\n from high fat diet group * HFD-2: sample 2 from high fat diet group *\n HFD-3: sample 3 from high fat diet group * HFD-4: sample 4 from high fat\n diet group * HFD-5: sample 5 from high fat diet group * ADF-1: sample 1\n from alternate day fasting group * ADF-2: sample 2 from alternate day\n fasting group * ADF-3: sample 3 from alternate day fasting group *\n ADF-4: sample 4 from alternate day fasting group * ADF-5: sample 5\n from alternate day fasting group * PF-1: sample 1 from pair feeding group\n * PF-2: sample 2 from pair feeding group * PF-3: sample 3 from pair\n feeding group * PF-4: sample 4 from pair feeding group * Taxonomy: genus\n category #### File: Fecal_metagenomic_species_level.csv\n **Description:** Gut microbiota species levels in different samples #####\n Variables * Index: genus name * CD-1: sample 1 from control group * CD-2:\n sample 2 from control group * CD-3: sample 3 from control group *\n CD-4: sample 4 from control group * CD-5: sample 5 from control group *\n HFD-1: sample 1 from high fat diet group * HFD-2: sample 2 from high fat\n diet group * HFD-3: sample 3 from high fat diet group * HFD-4: sample 4\n from high fat diet group * HFD-5: sample 5 from high fat diet group *\n ADF-1: sample 1 from alternate day fasting group * ADF-2: sample 2\n from alternate day fasting group * ADF-3: sample 3 from alternate day\n fasting group * ADF-4: sample 4 from alternate day fasting group *\n ADF-5: sample 5 from alternate day fasting group * PF-1: sample 1\n from pair feeding group * PF-2: sample 2 from pair feeding group *\n PF-3: sample 3 from pair feeding group * PF-4: sample 4 from pair feeding\n group * Taxonomy: species category #### File: phosphoproteomic_DES.csv\n **Description:** Protein phosphorylation levels in different samples #####\n Variables * Index: Amino acid residue(s) and position(s) of\n post-translational modification (PTM) sites on the protein * Accession:\n Protein accession number in the protein database * Description: Protein\n functional description * Gene: Gene name corresponding to the protein *\n Peptide: Amino acid sequence of the protein  * V1: resting condition\n sample 1 * V2: resting condition sample 2 * V3: resting condition sample 3\n * V4: resting condition sample 4 * V5: resting condition sample 5 * VT1:\n thrombin stimulation sample 1 * VT2: thrombin stimulation sample 2 *\n VT3: thrombin stimulation sample 3 * VT4: thrombin stimulation sample 4 *\n VT5: thrombin stimulation sample 5 * IPAT1: IPA preincubation and thrombin\n stimulation sample 1 * IPAT2: IPA preincubation and thrombin stimulation\n sample 2 * IPAT3: IPA preincubation and thrombin stimulation sample 3 *\n IPAT4: IPA preincubation and thrombin stimulation sample 4 * IPAT5: IPA\n preincubation and thrombin stimulation sample 5 #### File:\n taxa_table_genus.csv **Description:** Gut microbiota genus levels in\n different samples ##### Variables * \\#genus: genus name * F_HFD1: sample 1\n of mice receiving feces from HFD mice * F_HFD2: sample 2 of mice receiving\n feces from HFD mice * F_HFD3: sample 3 of mice receiving feces from HFD\n mice * F_ADF1: sample 1 of mice receiving feces from ADF mice *\n F_ADF2: sample 2 of mice receiving feces from ADF mice * F_ADF3: sample 3\n of mice receiving feces from ADF mice * F_ADF4: sample 4 of mice receiving\n feces from ADF mice * F_ADF5: sample 5 of mice receiving feces from ADF\n mice * taxonomy: genus category ## Code/software No specialized software\n is required. The data are provided in CSV format and can be viewed using\n standard spreadsheet software.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Natural Science Foundation of China","awardNumber":"82470513","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"funderName":"National Natural Science Foundation of China","awardNumber":"82500589","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"funderName":"National Natural Science Foundation of China","awardNumber":"82570577","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.1VHHMGR60</identifier>
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      <creatorName nameType="Personal">Feng, Ruijia</creatorName>
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      <creatorName nameType="Personal">Feng, Weiqi</creatorName>
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      <creatorName nameType="Personal">Luo, Yuyan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
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    <creator>
      <creatorName nameType="Personal">Peng, Guiyan</creatorName>
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    </creator>
    <creator>
      <creatorName nameType="Personal">Yang, Wenchao</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Long, Ting</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
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      <creatorName nameType="Personal">Cen, Meifeng</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01px77p81" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Sun Yat-sen Memorial Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liu, Yunchong</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
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      <creatorName nameType="Personal">Wei, Litai</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Huang, Kan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Zilun</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Chang, Guangqi</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
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  <titles>
    <title>
      Data from: Alternate day fasting attenuates metabolic
      dysfunction-associated arterial thrombotic risk via increasing
      indole-3-propionic acid
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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  <publicationYear>2026</publicationYear>
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    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Cardiovascular therapy</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Gut bacteria</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Metabolism</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82470513</awardNumber>
      <awardTitle/>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82500589</awardNumber>
      <awardTitle/>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82570577</awardNumber>
      <awardTitle/>
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  <contributors>
    <contributor contributorType="ContactPerson">
      <contributorName nameType="Personal">Feng, Ruijia</contributorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0009-0004-8494-0071</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/037p24858" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">The First Affiliated Hospital, Sun Yat-sen University</affiliation>
    </contributor>
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  <dates>
    <date dateType="Created">2025-04-02T04:07:16Z</date>
    <date dateType="Submitted">2025-09-03T02:17:22Z</date>
    <date dateType="Issued">2026-09-02T00:00:00Z</date>
    <date dateType="Available">2026-09-02T00:00:00Z</date>
  </dates>
  <language>en</language>
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    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1016/j.celrep.2026.118032</relatedIdentifier>
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  <descriptions>
    <description descriptionType="Abstract">
      Metabolic dysfunction-associated arterial thrombosis poses a major health
      challenge worldwide. Emerging studies have highlighted the metabolic
      benefits of alternate day fasting (ADF), providing insight into its
      potential therapeutic effect on thrombotic events. Here, we show that ADF
      attenuates platelet hyperreactivity and thrombotic tendency in obese mice
      by reshaping the gut microbiota.Further metabolomic analysis identify
      indole-3-propionic acid (IPA), a gut microbial derived metabolite, as key
      contributor of thrombosis-ameliorating effects of ADF. Mechanistically,
      IPA preserves the intraplatelet Rho-GTPase cycle homeostasis and
      suppresses downstream signaling pathways, thus inhibiting the platelet
      activation cascade and alleviating thrombus formation without affecting
      hemostasis in vivo. Moreover, patients with metabolic
      disturbance-associated arterial thrombosis exhibit significantly lower
      plasma IPA levels, which demonstrates strong predictive value for
      thrombotic risk and inversely correlates with platelet reactivity. Here,
      we show ADF’s protective role in metabolic dysfunction-associated
      thrombogenesis and validate IPA as a safe, effective antithrombotic agent
      with novel mechanistic insights.
    </description>
    <description descriptionType="TechnicalInfo">
      # Data from: Alternate day fasting attenuates metabolic
      dysfunction-associated arterial thrombotic risk via increasing
      indole-3-propionic acid Dataset DOI:
      [10.5061/dryad.1vhhmgr60](https://doi.org/10.5061/dryad.1vhhmgr60) ##
      Description of the data and file structure 1. For the dietary intervention
      study, male C57BL/6J mice (6-week-old) were randomly divided into 4 groups
      : (1) Control (Ctrl): standard experimental diet for 12 weeks; (2) High
      fat diet (HFD): diet consisting of 60 % fat for 12 weeks; (3) ADF: HFD for
      6 weeks, followed by a feeding regimen of every other day with HFD for the
      subsequent 6 weeks; (4) Paired feeding (PF): HFD for 6 weeks, followed by
      feeding with equivalent daily food intake to the ADF group with HFD for
      the next 6 weeks. The plasma samples were collected for metabolomics
      analysis and cecal feces were collected for metagenomic sequencing.  2.
      For fecal microbes transplantation (FMT) study, the male C57BL/6J mice
      received antibiotic cocktail to remove the original gut microbiota. Then,
      the mice were given fecal microbiota suspension from above HFD and ADF
      groups for 2 weeks. The cecal feces were collected for metagenomic
      sequencing.  3. Mice washed platelet samples were maintained in a resting
      state or stimulated with thrombin for 3 min with or without IPA
      preincubation. Protein samples were extracted for further phosphorylated
      proteome analysis.  ### Files and variables #### File:
      Plasma_metabolomic.csv **Description:** Plasma metabolites levels in
      different samples ##### Variables * Index: Metabolites index labelled
      by metware company * Compounds: Metabolites name * Class I: Primary
      category * Class II: Secondary category * Molecular weight (Da): Molecular
      weight * Formula: Formula * CD-1: sample 1 from control group * CD-2:
      sample 2 from control group * CD-3: sample 3 from control group *
      CD-4: sample 4 from control group * CD-5: sample 5 from control group *
      HFD-1: sample 1 from high fat diet group * HFD-2: sample 2 from high fat
      diet group * HFD-3: sample 3 from high fat diet group * HFD-4: sample 4
      from high fat diet group * HFD-5: sample 5 from high fat diet group *
      ADF-1: sample 1 from alternate day fasting group * ADF-2: sample 2
      from alternate day fasting group * ADF-3: sample 3 from alternate day
      fasting group * ADF-4: sample 4 from alternate day fasting group *
      ADF-5: sample 5 from alternate day fasting group * PF-1: sample 1
      from pair feeding group * PF-2: sample 2 from pair feeding group *
      PF-3: sample 3 from pair feeding group * PF-4: sample 4 from pair feeding
      group #### File: Fecal_metagenomic_genus_level.csv **Description:** Gut
      microbiota genus levels in different samples ##### Variables * Index:
      genus name * CD-1: sample 1 from control group * CD-2: sample 2
      from control group * CD-3: sample 3 from control group * CD-4: sample 4
      from control group * CD-5: sample 5 from control group * HFD-1: sample 1
      from high fat diet group * HFD-2: sample 2 from high fat diet group *
      HFD-3: sample 3 from high fat diet group * HFD-4: sample 4 from high fat
      diet group * HFD-5: sample 5 from high fat diet group * ADF-1: sample 1
      from alternate day fasting group * ADF-2: sample 2 from alternate day
      fasting group * ADF-3: sample 3 from alternate day fasting group *
      ADF-4: sample 4 from alternate day fasting group * ADF-5: sample 5
      from alternate day fasting group * PF-1: sample 1 from pair feeding group
      * PF-2: sample 2 from pair feeding group * PF-3: sample 3 from pair
      feeding group * PF-4: sample 4 from pair feeding group * Taxonomy: genus
      category #### File: Fecal_metagenomic_species_level.csv
      **Description:** Gut microbiota species levels in different samples #####
      Variables * Index: genus name * CD-1: sample 1 from control group * CD-2:
      sample 2 from control group * CD-3: sample 3 from control group *
      CD-4: sample 4 from control group * CD-5: sample 5 from control group *
      HFD-1: sample 1 from high fat diet group * HFD-2: sample 2 from high fat
      diet group * HFD-3: sample 3 from high fat diet group * HFD-4: sample 4
      from high fat diet group * HFD-5: sample 5 from high fat diet group *
      ADF-1: sample 1 from alternate day fasting group * ADF-2: sample 2
      from alternate day fasting group * ADF-3: sample 3 from alternate day
      fasting group * ADF-4: sample 4 from alternate day fasting group *
      ADF-5: sample 5 from alternate day fasting group * PF-1: sample 1
      from pair feeding group * PF-2: sample 2 from pair feeding group *
      PF-3: sample 3 from pair feeding group * PF-4: sample 4 from pair feeding
      group * Taxonomy: species category #### File: phosphoproteomic_DES.csv
      **Description:** Protein phosphorylation levels in different samples #####
      Variables * Index: Amino acid residue(s) and position(s) of
      post-translational modification (PTM) sites on the protein * Accession:
      Protein accession number in the protein database * Description: Protein
      functional description * Gene: Gene name corresponding to the protein *
      Peptide: Amino acid sequence of the protein  * V1: resting condition
      sample 1 * V2: resting condition sample 2 * V3: resting condition sample 3
      * V4: resting condition sample 4 * V5: resting condition sample 5 * VT1:
      thrombin stimulation sample 1 * VT2: thrombin stimulation sample 2 *
      VT3: thrombin stimulation sample 3 * VT4: thrombin stimulation sample 4 *
      VT5: thrombin stimulation sample 5 * IPAT1: IPA preincubation and thrombin
      stimulation sample 1 * IPAT2: IPA preincubation and thrombin stimulation
      sample 2 * IPAT3: IPA preincubation and thrombin stimulation sample 3 *
      IPAT4: IPA preincubation and thrombin stimulation sample 4 * IPAT5: IPA
      preincubation and thrombin stimulation sample 5 #### File:
      taxa_table_genus.csv **Description:** Gut microbiota genus levels in
      different samples ##### Variables * \#genus: genus name * F_HFD1: sample 1
      of mice receiving feces from HFD mice * F_HFD2: sample 2 of mice receiving
      feces from HFD mice * F_HFD3: sample 3 of mice receiving feces from HFD
      mice * F_ADF1: sample 1 of mice receiving feces from ADF mice *
      F_ADF2: sample 2 of mice receiving feces from ADF mice * F_ADF3: sample 3
      of mice receiving feces from ADF mice * F_ADF4: sample 4 of mice receiving
      feces from ADF mice * F_ADF5: sample 5 of mice receiving feces from ADF
      mice * taxonomy: genus category ## Code/software No specialized software
      is required. The data are provided in CSV format and can be viewed using
      standard spreadsheet software.
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