{"data":{"id":"10.5061/dryad.1c59zw3v7","type":"dois","attributes":{"doi":"10.5061/dryad.1c59zw3v7","prefix":"10.5061","suffix":"dryad.1c59zw3v7","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Opic, Petra","nameType":"Personal","givenName":"Petra","familyName":"Opic","affiliation":["University Hospital of Basel"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3962-4972","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Automated, quantitative pupillometry in the critically ill: a systematic review of the literature: online supplementary data"}],"publisher":"Dryad","container":{},"publicationYear":2021,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2021-05-05T14:25:11Z","dateType":"Submitted"},{"date":"2021-05-14T00:00:00Z","dateType":"Issued"},{"date":"2021-05-14T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1212/wnl.0000000000012295","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["207249 bytes"],"formats":[],"version":"2","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Objective: A systematic literature search has been performed to identify\n potential confounders for outcome prediction using pupillary light reflex\n in adult critically ill patients, as measured by handheld automated\n pupillometry devices. Methods: Three digital databases (PubMed, EmBase,\n Cochrane) were systematically searched. Articles published between\n 1990-2019 in adult patients, using monocular automated handheld devices\n were considered. Studies were classified according to the OCEBM\n classification (level 1 represents the highest, level 5 the lowest level\n of evidence). Case reports, original research and systematic reviews were\n included and cross-referenced.  Results: Using 202 search terms,\n 58 eligible articles reporting on the use of handheld pupillometry in the\n critically ill could be identified, considering 3246 patients. The highest\n level of evidence came from 10 randomized trials and 19 prospective\n observational studies. The level of evidence was mostly 2 to 3 and highest\n with studies regarding the potential confounding effects of pain, the use\n of opioids and increased intracranial pressure. Additional potential\n confounders found are SSRIs, α2-adregenic receptor agonists and NMDA\n antagonists. Conclusions: The pupillary light reflex is susceptible to\n factors resulting from underlying comorbidities and effects of treatment\n regimes. Scenarios frequently encountered in critical care, such as pain,\n the use of opioids, and proof of increased intracranial pressure have\n potential confounding effects on outcome and pupillary reflexes. When\n treatment is guided by pupillary metrics, such confounders put patients at\n risk of over- or undertreatment. Future research should validate and\n identify additional confounders, as our review suggests that even more\n unexplored confounders may exist.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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