{"data":{"id":"10.4121/0b66dd27-ee11-43f2-b58b-fff98463f944","type":"dois","attributes":{"doi":"10.4121/0b66dd27-ee11-43f2-b58b-fff98463f944","prefix":"10.4121","suffix":"0b66dd27-ee11-43f2-b58b-fff98463f944","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Cruijsen, Esther","nameType":"Personal","givenName":"Esther","familyName":"Cruijsen","nameIdentifiers":[{"nameIdentifier":"0000-0002-8348-0243","nameIdentifierScheme":"https://orcid.org/"}],"affiliation":[]}],"titles":[{"title":"Data underlying the publication \"Association of body mass index and waist circumference with long-term mortality risk in 10,370 coronary patients and potential modification by lifestyle and health determinants\""}],"publisher":"4TU.ResearchData","container":{},"publicationYear":2024,"subjects":[{"subject":"Cardiorespiratory Medicine and Haematology","subjectScheme":"Australian and New Zealand Standard Research Classification (ANZSRC), 2008","classificationCode":"1102"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Clinical Health (organs, Diseases and Abnormal Conditions)","subjectScheme":"Australian and New Zealand Standard Research Classification (ANZSRC), 2008","classificationCode":"9201"},{"subject":"Nutrition and Dietetics","subjectScheme":"Australian and New Zealand Standard Research Classification (ANZSRC), 2008","classificationCode":"1111"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medical Biochemistry and Metabolomics","subjectScheme":"Australian and New Zealand Standard Research Classification (ANZSRC), 2008","classificationCode":"1101"},{"subject":"Health","subjectScheme":"Australian and New Zealand Standard Research Classification (ANZSRC), 2008","classificationCode":"92"},{"subject":"Medical and Health Sciences","subjectScheme":"Australian and New Zealand Standard Research Classification (ANZSRC), 2008","classificationCode":"11"},{"subject":"body mass index"},{"subject":"waist circumference"},{"subject":"lifestyle factors"},{"subject":"all-cause mortality"},{"subject":"cardiovascular mortality"},{"subject":"coronary artery patients"},{"subject":"Alpha Omega Cohort"},{"subject":"UCC-SMART"}],"contributors":[{"name":"Departement Agrotechnologie En Voedingswetenschappen, Wageningen University \u0026 Research","nameType":"Organizational","affiliation":[],"contributorType":"Other","nameIdentifiers":[]}],"dates":[{"date":"2024-03-28","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[".pdf, .docx, .sav, .sas7bdat"],"version":"1","rightsList":[],"descriptions":[{"description":"Body adiposity is known to affect mortality risk in patients with coronary artery disease (CAD). We examined associations of body mass index (BMI) and waist circumference (WC) with long term mortality in Dutch CAD patients, and potential and effect modification of these associations by lifestyle and health determinants.\u003cbr\u003e10,370 CAD patients (mean age ~65 y; 20% female; \u0026gt;80% on cardiovascular drugs) from the prospective Alpha Omega Cohort and Utrecht Cardiovascular Cohort – Secondary Manifestations of ARTerial disease study were included. Cox models were used to estimate categorical and continuous associations (using restricted cubic splines) of measured BMI and WC with all-cause and cardiovascular mortality risk, adjusting for age, sex, smoking, alcohol, physical activity and educational level. Analyses were repeated in subgroups of lifestyle factors (smoking, physical activity, diet quality), education and health determinants (diabetes, self-rated health).\u003cbr\u003eDuring ~10 years of follow-up (91,947 person-years), 3,553 deaths occurred, including 1,620 from cardiovascular disease. U-shaped relationships were found forBMI and mortality risk, with the lowest risk for overweight patients (BMI ~27 kg/m2). For obesity (BMI ≥30), the HR for all-cause mortality was 1.31 (95% CI: 1.11, 1.41) in male patients and 1.10 (95% CI: 0.92, 1.30) in female patients, compared to BMI 25-30 kg/m2. WC was also non-linearly associated with mortality, and HRs were 1.18 (95%CI:1.06, 1.30) in males and 1.31 (95%CI:1.05, 1.64) in females for the highest vs. middle category of WC. Results for cardiovascular mortality were mostly in line with the results for all-cause mortality. U-shaped associations were found in most subgroups, associations were moderately modified by physical activity, smoking and educational level.\u003cbr\u003eCAD patients with obesity and a large WC were at increased risk of longterm CVD and all-cause mortality, while mildly overweight patients had the lowest risk. These associations were consistent across subgroups of patients with different lifestyles and health status.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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