{"data":{"id":"10.25392/leicester.data.7610933","type":"dois","attributes":{"doi":"10.25392/leicester.data.7610933","prefix":"10.25392","suffix":"leicester.data.7610933","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Himanshu Kaul","affiliation":[],"nameIdentifiers":[]},{"name":"Brightling, Christopher","nameType":"Personal","givenName":"Christopher","familyName":"Brightling","affiliation":[],"nameIdentifiers":[]},{"name":"Smallwood, Rod","nameType":"Personal","givenName":"Rod","familyName":"Smallwood","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Clinical level agent-based model of pathological airway remodeling in asthma"}],"publisher":"University of Leicester","container":{},"publicationYear":2019,"subjects":[{"subject":"10202 Biological Mathematics","subjectScheme":"FOR"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"60106 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Computational Biology"},{"subject":"111502 Clinical Pharmacology and Therapeutics","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111602 Human Biophysics","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Basic medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"80110 Simulation and Modelling","subjectScheme":"FOR"},{"subject":"FOS: Computer and information sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Computer and information sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2019-01-21","dateType":"Created"},{"date":"2019-02-12","dateType":"Updated"},{"date":"2019","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["2667118 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution Non Commercial 4.0 International","rightsUri":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-nc-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The following contains information regarding the uploaded agent-based model capturing asthma pathogenesis in a virtual human airway to make clinical-level predictions. This model was developed considering a Strahler Order 3 airway and is based on interactions between the epithelial, mesenchymal, and inflammatory elements of an airway. Pathological remodeling during asthma in this model, therefore, emerges as a result of dynamic interplay between these elements across multiple spatial and temporal scales. The model was developed to be drug agnostic and used to predict the impact of two drugs, with different pharmacodynamics, on the muscle mass of the virtual airway with severe asthma. Model outcomes were validated by comparing against clinical data and in vitro studies.\u003cbr\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://leicester.figshare.com/articles/Clinical_level_agent-based_model_of_pathological_airway_remodeling_in_asthma/7610933","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2019-01-21T16:53:02.000Z","registered":"2019-01-21T16:53:03.000Z","published":"2019","updated":"2020-08-27T20:21:21.000Z"},"relationships":{"client":{"data":{"id":"figshare.lest","type":"clients"}},"provider":{"data":{"id":"wnij","type":"providers"}},"media":{"data":{"id":"10.25392/leicester.data.7610933","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data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