{"data":{"id":"10.25384/sage.c.4169708.v1","type":"dois","attributes":{"doi":"10.25384/sage.c.4169708.v1","prefix":"10.25384","suffix":"sage.c.4169708.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Failla, Michelle D","nameType":"Personal","givenName":"Michelle D","familyName":"Failla","affiliation":[],"nameIdentifiers":[]},{"name":"Estephan J Moana-Filho","affiliation":[],"nameIdentifiers":[]},{"name":"Essick, Greg K","nameType":"Personal","givenName":"Greg K","familyName":"Essick","affiliation":[],"nameIdentifiers":[]},{"name":"Baranek, Grace T","nameType":"Personal","givenName":"Grace T","familyName":"Baranek","affiliation":[],"nameIdentifiers":[]},{"name":"Rogers, Baxter P","nameType":"Personal","givenName":"Baxter P","familyName":"Rogers","affiliation":[],"nameIdentifiers":[]},{"name":"Cascio, Carissa J","nameType":"Personal","givenName":"Carissa J","familyName":"Cascio","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Initially intact neural responses to pain in autism are diminished during\n          sustained pain"}],"publisher":"Figshare","container":{},"publicationYear":2017,"subjects":[{"subject":"170199 Psychology not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Psychology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110319 Psychiatry (incl. Psychotherapy)","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111799 Public Health and Health Services not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Education"},{"subject":"130312 Special Education and Disability","subjectScheme":"FOR"},{"subject":"FOS: Educational sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2018-07-18","dateType":"Created"},{"date":"2018-07-18","dateType":"Updated"},{"date":"2017","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1177/1362361317696043","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.25384/sage.c.4169708","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"Pain assessments typically depend on self-report of the pain experience. Yet, in\n          individuals with autism spectrum disorders, this can be an unreliable due to communication\n          difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain\n          suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide\n          insight into mechanisms underlying pain behaviors. The neural pain signature reliably\n          responds to painful stimulation and is modulated by other outside regions, affecting the\n          pain experience. In this first functional magnetic resonance imaging study of pain in\n          autism spectrum disorder, we investigated neural responses to pain in 15 adults with\n          autism spectrum disorder relative to a typical comparison group (n = 16). We explored\n          temporal and spatial properties of the neural pain signature and its modulators during\n          sustained heat pain. The two groups had indistinguishable pain ratings and neural pain\n          signature responses during acute pain; yet, we observed strikingly reduced neural pain\n          signature response in autism spectrum disorder during sustained pain and after stimulus\n          offset. The posterior cingulate cortex, a neural pain signature modulating region,\n          mirrored this late signal reduction in autism spectrum disorder. Intact early responses,\n          followed by diminished late responses to sustained pain, may reflect altered pain coping\n          or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to\n          initial versus protracted pain may clarify the coexistence of both hypo- and\n          hyperresponsiveness to pain in autism spectrum disorder.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtMyIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtMyBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC0zL21ldGFkYXRhLnhzZCI+CiAgPGlkZW50aWZpZXIgaWRlbnRpZmllclR5cGU9IkRPSSI+MTAuMjUzODQvU0FHRS5DLjQxNjk3MDguVjE8L2lkZW50aWZpZXI+CiAgPGNyZWF0b3JzPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5NaWNoZWxsZSBEIEZhaWxsYTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkVzdGVwaGFuIEogTW9hbmEtRmlsaG88L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5HcmVnIEsgRXNzaWNrPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+R3JhY2UgVCBCYXJhbmVrPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+QmF4dGVyIFAgUm9nZXJzPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+Q2FyaXNzYSBKIENhc2NpbzwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgPC9jcmVhdG9ycz4KICA8dGl0bGVzPgogICAgPHRpdGxlPkluaXRpYWxseSBpbnRhY3QgbmV1cmFsIHJlc3BvbnNlcyB0byBwYWluIGluIGF1dGlzbSBhcmUgZGltaW5pc2hlZCBkdXJpbmcKICAgICAgICAgIHN1c3RhaW5lZCBwYWluPC90aXRsZT4KICA8L3RpdGxlcz4KICA8ZGVzY3JpcHRpb25zPgogICAgPGRlc2NyaXB0aW9uIGRlc2NyaXB0aW9uVHlwZT0iQWJzdHJhY3QiPiZsdDtkaXYmZ3Q7Jmx0O3AmZ3Q7UGFpbiBhc3Nlc3NtZW50cyB0eXBpY2FsbHkgZGVwZW5kIG9uIHNlbGYtcmVwb3J0IG9mIHRoZSBwYWluIGV4cGVyaWVuY2UuIFlldCwgaW4KICAgICAgICAgIGluZGl2aWR1YWxzIHdpdGggYXV0aXNtIHNwZWN0cnVtIGRpc29yZGVycywgdGhpcyBjYW4gYmUgYW4gdW5yZWxpYWJsZSBkdWUgdG8gY29tbXVuaWNhdGlvbgogICAgICAgICAgZGlmZmljdWx0aWVzLiBJbXBvcnRhbnRseSwgb2JzZXJ2YXRpb25zIG9mIGJlaGF2aW9yYWwgaHlwby0gYW5kIGh5cGVycmVzcG9uc2l2aXR5IHRvIHBhaW4KICAgICAgICAgIHN1Z2dlc3QgYWx0ZXJlZCBwYWluIHNlbnNpdGl2aXR5IGluIGF1dGlzbSBzcGVjdHJ1bSBkaXNvcmRlci4gTmV1cm9pbWFnaW5nIG1heSBwcm92aWRlCiAgICAgICAgICBpbnNpZ2h0IGludG8gbWVjaGFuaXNtcyB1bmRlcmx5aW5nIHBhaW4gYmVoYXZpb3JzLiBUaGUgbmV1cmFsIHBhaW4gc2lnbmF0dXJlIHJlbGlhYmx5CiAgICAgICAgICByZXNwb25kcyB0byBwYWluZnVsIHN0aW11bGF0aW9uIGFuZCBpcyBtb2R1bGF0ZWQgYnkgb3RoZXIgb3V0c2lkZSByZWdpb25zLCBhZmZlY3RpbmcgdGhlCiAgICAgICAgICBwYWluIGV4cGVyaWVuY2UuIEluIHRoaXMgZmlyc3QgZnVuY3Rpb25hbCBtYWduZXRpYyByZXNvbmFuY2UgaW1hZ2luZyBzdHVkeSBvZiBwYWluIGluCiAgICAgICAgICBhdXRpc20gc3BlY3RydW0gZGlzb3JkZXIsIHdlIGludmVzdGlnYXRlZCBuZXVyYWwgcmVzcG9uc2VzIHRvIHBhaW4gaW4gMTUgYWR1bHRzIHdpdGgKICAgICAgICAgIGF1dGlzbSBzcGVjdHJ1bSBkaXNvcmRlciByZWxhdGl2ZSB0byBhIHR5cGljYWwgY29tcGFyaXNvbiBncm91cCAobuKAiT3igIkxNikuIFdlIGV4cGxvcmVkCiAgICAgICAgICB0ZW1wb3JhbCBhbmQgc3BhdGlhbCBwcm9wZXJ0aWVzIG9mIHRoZSBuZXVyYWwgcGFpbiBzaWduYXR1cmUgYW5kIGl0cyBtb2R1bGF0b3JzIGR1cmluZwogICAgICAgICAgc3VzdGFpbmVkIGhlYXQgcGFpbi4gVGhlIHR3byBncm91cHMgaGFkIGluZGlzdGluZ3Vpc2hhYmxlIHBhaW4gcmF0aW5ncyBhbmQgbmV1cmFsIHBhaW4KICAgICAgICAgIHNpZ25hdHVyZSByZXNwb25zZXMgZHVyaW5nIGFjdXRlIHBhaW47IHlldCwgd2Ugb2JzZXJ2ZWQgc3RyaWtpbmdseSByZWR1Y2VkIG5ldXJhbCBwYWluCiAgICAgICAgICBzaWduYXR1cmUgcmVzcG9uc2UgaW4gYXV0aXNtIHNwZWN0cnVtIGRpc29yZGVyIGR1cmluZyBzdXN0YWluZWQgcGFpbiBhbmQgYWZ0ZXIgc3RpbXVsdXMKICAgICAgICAgIG9mZnNldC4gVGhlIHBvc3RlcmlvciBjaW5ndWxhdGUgY29ydGV4LCBhIG5ldXJhbCBwYWluIHNpZ25hdHVyZSBtb2R1bGF0aW5nIHJlZ2lvbiwKICAgICAgICAgIG1pcnJvcmVkIHRoaXMgbGF0ZSBzaWduYWwgcmVkdWN0aW9uIGluIGF1dGlzbSBzcGVjdHJ1bSBkaXNvcmRlci4gSW50YWN0IGVhcmx5IHJlc3BvbnNlcywKICAgICAgICAgIGZvbGxvd2VkIGJ5IGRpbWluaXNoZWQgbGF0ZSByZXNwb25zZXMgdG8gc3VzdGFpbmVkIHBhaW4sIG1heSByZWZsZWN0IGFsdGVyZWQgcGFpbiBjb3BpbmcKICAgICAgICAgIG9yIGV2YWx1YXRpb24gaW4gYXV0aXNtIHNwZWN0cnVtIGRpc29yZGVyLiBFdmlkZW5jZSBvZiBhIGRpY2hvdG9tb3VzIG5ldXJhbCByZXNwb25zZSB0bwogICAgICAgICAgaW5pdGlhbCB2ZXJzdXMgcHJvdHJhY3RlZCBwYWluIG1heSBjbGFyaWZ5IHRoZSBjb2V4aXN0ZW5jZSBvZiBib3RoIGh5cG8tIGFuZAogICAgICAgICAgaHlwZXJyZXNwb25zaXZlbmVzcyB0byBwYWluIGluIGF1dGlzbSBzcGVjdHJ1bSBkaXNvcmRlci4mbHQ7L3AmZ3Q7Jmx0Oy9kaXYmZ3Q7PC9kZXNjcmlwdGlvbj4KICA8L2Rlc2NyaXB0aW9ucz4KICA8c3ViamVjdHM+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjE3MDE5OSBQc3ljaG9sb2d5IG5vdCBlbHNld2hlcmUgY2xhc3NpZmllZDwvc3ViamVjdD4KICAgIDxzdWJqZWN0IHNjaGVtZVVSST0iaHR0cDovL3d3dy5hYnMuZ292LmF1L2F1c3N0YXRzL2Fic0AubnNmLzAvNkJCNDI3QUI5Njk2QzIyNUNBMjU3NDE4MDAwNDQ2M0UiIHN1YmplY3RTY2hlbWU9IkZPUiI+MTEwMzE5IFBzeWNoaWF0cnkgKGluY2wuIFBzeWNob3RoZXJhcHkpPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj4xMTE3OTkgUHVibGljIEhlYWx0aCBhbmQgSGVhbHRoIFNlcnZpY2VzIG5vdCBlbHNld2hlcmUgY2xhc3NpZmllZDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkVkdWNhdGlvbjwvc3ViamVjdD4KICAgIDxzdWJqZWN0IHNjaGVtZVVSST0iaHR0cDovL3d3dy5hYnMuZ292LmF1L2F1c3N0YXRzL2Fic0AubnNmLzAvNkJCNDI3QUI5Njk2QzIyNUNBMjU3NDE4MDAwNDQ2M0UiIHN1YmplY3RTY2hlbWU9IkZPUiI+MTcwMTk5IFBzeWNob2xvZ3kgbm90IGVsc2V3aGVyZSBjbGFzc2lmaWVkPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc2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