{"data":{"id":"10.25384/sage.c.4119158.v1","type":"dois","attributes":{"doi":"10.25384/sage.c.4119158.v1","prefix":"10.25384","suffix":"sage.c.4119158.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"X. Yuan","affiliation":[],"nameIdentifiers":[]},{"name":"X. Pei","affiliation":[],"nameIdentifiers":[]},{"name":"Y. Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"U.S. Tulu","affiliation":[],"nameIdentifiers":[]},{"name":"B. Liu","affiliation":[],"nameIdentifiers":[]},{"name":"J.A. Helms","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A Wnt-Responsive PDL Population Effectuates Extraction Socket Healing"}],"publisher":"Figshare","container":{},"publicationYear":2018,"subjects":[{"subject":"110599 Dentistry not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"91299 Materials Engineering not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Materials engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2018-05-31","dateType":"Created"},{"date":"2018-05-31","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1177/0022034518755719","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.25384/sage.c.4119158","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"Stem cells residing in the periodontal ligament (PDL) support the homeostasis of the periodontium, but their in vivo identity, source(s), and function(s) remain poorly understood. Here, using a lineage-tracing mouse strain, we identified a quiescent Wnt-responsive population in the PDL that became activated in response to tooth extraction. The Wnt-responsive population expanded by proliferation, then migrated from the PDL remnants that remained attached to bundle bone, into the socket. Once there, the Wnt-responsive progeny upregulated osteogenic protein expression, differentiated into osteoblasts, and generated the new bone that healed the socket. Using a liposomal WNT3A protein therapeutic, we showed that a single application at the time of extraction was sufficient to accelerate extraction socket healing 2-fold. Collectively, these data identify a new stem cell population in the intact periodontium that is directly responsible for alveolar bone healing after tooth removal.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/collections/A_Wnt-Responsive_PDL_Population_Effectuates_Extraction_Socket_Healing/4119158/1","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-3","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":1,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2018-05-31T17:25:06.000Z","registered":"2018-05-31T17:25:06.000Z","published":"2018","updated":"2024-08-28T05:38:12.000Z"},"relationships":{"client":{"data":{"id":"sage.journals","type":"clients"}},"provider":{"data":{"id":"sage","type":"providers"}},"media":{"data":{"id":"10.25384/sage.c.4119158.v1","type":"med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