{"data":{"id":"10.25384/sage.c.4105118","type":"dois","attributes":{"doi":"10.25384/sage.c.4105118","prefix":"10.25384","suffix":"sage.c.4105118","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"F. Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Y. Zhou","affiliation":[],"nameIdentifiers":[]},{"name":"J. Zhou","affiliation":[],"nameIdentifiers":[]},{"name":"M. Xu","affiliation":[],"nameIdentifiers":[]},{"name":"W. Zheng","affiliation":[],"nameIdentifiers":[]},{"name":"W. Huang","affiliation":[],"nameIdentifiers":[]},{"name":"W. Zhou","affiliation":[],"nameIdentifiers":[]},{"name":"Y. Shen","affiliation":[],"nameIdentifiers":[]},{"name":"K. Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Y. Wu","affiliation":[],"nameIdentifiers":[]},{"name":"D. Zou","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Comparison of Intraoral Bone Regeneration with Iliac and Alveolar BMSCs"}],"publisher":"Figshare","container":{},"publicationYear":2018,"subjects":[{"subject":"110599 Dentistry not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"91299 Materials Engineering not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Materials engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2018-05-18","dateType":"Created"},{"date":"2018-05-18","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1177/0022034518772283","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"This study compared the osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) of iliac and alveolar origins (I-BMSCs and Al-BMSCs, respectively), which were transplanted in combination with β tricalcium phosphate (β-TCP) in peri-implant bone defects to investigate the osseointegration between dental implants and tissue-engineered bone in dogs. Specifically, I-BMSCs and Al-BMSCs were cultured, characterized, and seeded on β-TCP and subjected to immunoblotting analyses and alkaline phosphatase activity assays. Subsequently, these cell-seeded scaffolds were implanted into defects that were freshly generated in the mandibular premolar areas of 4 dogs. The defects were covered with β-TCP + Al-BMSCs (\u003ci\u003en\u003c/i\u003e = 6), β-TCP + I-BMSCs (\u003ci\u003en\u003c/i\u003e = 6), or β-TCP (\u003ci\u003en\u003c/i\u003e = 6) or served as the blank control (\u003ci\u003en\u003c/i\u003e = 6). After healing for 12 wk, the formation and mineralization of new bones were assessed through micro–computed tomographic, histologic, and histomorphometric analyses, and bone-to-implant contacts were measured in the specimens. It was evident that in this large animal model, I-BMSCs and Al-BMSCs manifested similarly strong osteogenic potential, as significantly more new bone was formed in the Al-BMSC and I-BMSC groups than otherwise (\u003ci\u003eP\u003c/i\u003e \u0026lt; 0.01). Therefore, Al-BMSCs are emerging as an efficient alternative for autologous mesenchymal stem cells in regenerative dental and maxillofacial therapies. I-BMSCs, if not restricted in their bioavailability, can also be of great utility in bone tissue–engineering applications.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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