{"data":{"id":"10.25384/sage.c.4100822.v1","type":"dois","attributes":{"doi":"10.25384/sage.c.4100822.v1","prefix":"10.25384","suffix":"sage.c.4100822.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Rubenstein, Eric","nameType":"Personal","givenName":"Eric","familyName":"Rubenstein","affiliation":[],"nameIdentifiers":[]},{"name":"Wiggins, Lisa D","nameType":"Personal","givenName":"Lisa D","familyName":"Wiggins","affiliation":[],"nameIdentifiers":[]},{"name":"Schieve, Laura A","nameType":"Personal","givenName":"Laura A","familyName":"Schieve","affiliation":[],"nameIdentifiers":[]},{"name":"Chyrise Bradley","affiliation":[],"nameIdentifiers":[]},{"name":"DiGuiseppi, Carolyn","nameType":"Personal","givenName":"Carolyn","familyName":"DiGuiseppi","affiliation":[],"nameIdentifiers":[]},{"name":"Moody, Eric","nameType":"Personal","givenName":"Eric","familyName":"Moody","affiliation":[],"nameIdentifiers":[]},{"name":"Pandey, Juhi","nameType":"Personal","givenName":"Juhi","familyName":"Pandey","affiliation":[],"nameIdentifiers":[]},{"name":"Pretzel, Rebecca Edmondson","nameType":"Personal","givenName":"Rebecca Edmondson","familyName":"Pretzel","affiliation":[],"nameIdentifiers":[]},{"name":"Howard, Annie Green","nameType":"Personal","givenName":"Annie Green","familyName":"Howard","affiliation":[],"nameIdentifiers":[]},{"name":"Olshan, Andrew F","nameType":"Personal","givenName":"Andrew F","familyName":"Olshan","affiliation":[],"nameIdentifiers":[]},{"name":"Pence, Brian W","nameType":"Personal","givenName":"Brian W","familyName":"Pence","affiliation":[],"nameIdentifiers":[]},{"name":"Daniels, Julie","nameType":"Personal","givenName":"Julie","familyName":"Daniels","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Associations between parental broader autism phenotype and child autism\n          spectrum disorder phenotype in the Study to Explore Early Development"}],"publisher":"Figshare","container":{},"publicationYear":2018,"subjects":[{"subject":"170199 Psychology not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Psychology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110319 Psychiatry (incl. Psychotherapy)","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111799 Public Health and Health Services not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Education"},{"subject":"130312 Special Education and Disability","subjectScheme":"FOR"},{"subject":"FOS: Educational sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2018-05-15","dateType":"Created"},{"date":"2018-10-05","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1177/1362361317753563","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.25384/sage.c.4100822","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"The autism spectrum disorder phenotype varies by social and communication ability and\n          co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse,\n          with myriad potential genetic origins and environmental risk factors. Examining the\n          influence of parental broader autism phenotype—a set of sub-clinical characteristics of\n          autism spectrum disorder—on child autism spectrum disorder phenotypes may help reduce\n          heterogeneity in potential genetic predisposition for autism spectrum disorder. We\n          assessed the associations between parental broader autism phenotype and child phenotype\n          among children of age 30–68 months enrolled in the Study to Explore Early Development\n          (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent\n          classes derived from multiple developmental and behavioral measures: \u003ci\u003eMild Language\n            Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation\u003c/i\u003e\n          (e.g. anxiety/depression), \u003ci\u003eGeneral Developmental Delay\u003c/i\u003e, and\n            \u003ci\u003eSignificant Developmental Delay with Repetitive Motor Behaviors\u003c/i\u003e. Scores\n          on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader\n          autism phenotype in at least one parent was associated with a child having increased odds\n          of being classified as mild language and motor delay with dysregulation compared to\n          significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95%\n          confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were\n          more likely to have a phenotype qualitatively similar to broader autism phenotype\n          presentation; this may have implications for etiologic research.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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