{"data":{"id":"10.25384/sage.c.4068926","type":"dois","attributes":{"doi":"10.25384/sage.c.4068926","prefix":"10.25384","suffix":"sage.c.4068926","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"I. Vidovic-Zdrilic","affiliation":[],"nameIdentifiers":[]},{"name":"K.H. Vining","affiliation":[],"nameIdentifiers":[]},{"name":"A. Vijaykumar","affiliation":[],"nameIdentifiers":[]},{"name":"I. Kalajzic","affiliation":[],"nameIdentifiers":[]},{"name":"D.J. Mooney","affiliation":[],"nameIdentifiers":[]},{"name":"M. Mina","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"FGF2 Enhances Odontoblast Differentiation by αSMA\u003csup\u003e+\u003c/sup\u003e Progenitors In Vivo"}],"publisher":"Figshare","container":{},"publicationYear":2018,"subjects":[{"subject":"110599 Dentistry not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"91299 Materials Engineering not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Materials engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2018-04-13","dateType":"Created"},{"date":"2018-04-13","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1177/0022034518769827","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo. We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis. Our results demonstrate that early delivery of exogenous FGF2 to exposed pulp led to proliferative expansion of αSMA-tdTomato\u003csup\u003e+\u003c/sup\u003e cells and their accelerated differentiation into odontoblasts. In vivo lineage-tracing experiments showed that the calcified bridge/reparative dentin in FGF2-treated pulps were lined with an increased number of \u003ci\u003eDspp\u003c/i\u003e\u003csup\u003e+\u003c/sup\u003e odontoblasts and devoid of \u003ci\u003eBSP\u003c/i\u003e\u003csup\u003e+\u003c/sup\u003e osteoblasts. The increased number of odontoblasts derived from αSMA-tdTomato\u003csup\u003e+\u003c/sup\u003e cells and the formation of reparative dentin devoid of osteoblasts provide in vivo evidence for the stimulatory effects of FGF signaling on odontoblast differentiation from early progenitors in dental pulp.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/collections/FGF2_Enhances_Odontoblast_Differentiation_by_SMA_sup_sup_Progenitors_In_Vivo/4068926","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-3","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":1,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2018-04-13T11:03:47.000Z","registered":"2018-04-13T11:03:48.000Z","published":"2018","updated":"2024-08-28T03:40:43.000Z"},"relationships":{"client":{"data":{"id":"sage.journals","type":"clients"}},"provider":{"data":{"id":"sage","type":"providers"}},"media":{"data":{"id":"10.25384/sage.c.4068926","type":"media"}},"references":{"data":[{"id":"10.1177/0022034518769827","type":"dois"}]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}