{"data":{"id":"10.25384/sage.c.4402316","type":"dois","attributes":{"doi":"10.25384/sage.c.4402316","prefix":"10.25384","suffix":"sage.c.4402316","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Planche, Vincent","nameType":"Personal","givenName":"Vincent","familyName":"Planche","affiliation":[],"nameIdentifiers":[]},{"name":"Su, Jason H","nameType":"Personal","givenName":"Jason H","familyName":"Su","affiliation":[],"nameIdentifiers":[]},{"name":"Mournet, Sandy","nameType":"Personal","givenName":"Sandy","familyName":"Mournet","affiliation":[],"nameIdentifiers":[]},{"name":"Manojkumar Saranathan","affiliation":[],"nameIdentifiers":[]},{"name":"Dousset, Vincent","nameType":"Personal","givenName":"Vincent","familyName":"Dousset","affiliation":[],"nameIdentifiers":[]},{"name":"Han, May","nameType":"Personal","givenName":"May","familyName":"Han","affiliation":[],"nameIdentifiers":[]},{"name":"Rutt, Brian K","nameType":"Personal","givenName":"Brian K","familyName":"Rutt","affiliation":[],"nameIdentifiers":[]},{"name":"Tourdias, Thomas","nameType":"Personal","givenName":"Thomas","familyName":"Tourdias","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis"}],"publisher":"Figshare","container":{},"publicationYear":2019,"subjects":[{"subject":"110904 Neurology and Neuromuscular Diseases","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111702 Aged Health Care","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2019-02-15","dateType":"Created"},{"date":"2019-02-15","dateType":"Updated"},{"date":"2019","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1177/1352458519828297","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"Background:Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging.Methods:White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients (\u003ci\u003en\u003c/i\u003e = 15) and matched controls (\u003ci\u003en\u003c/i\u003e = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Volumes of 12 thalamic nuclei were measured using an automatic segmentation pipeline specifically developed for WMn-MPRAGE.Results:WMn-MPRAGE showed more thalamic MS lesions (\u003ci\u003en\u003c/i\u003e = 35 in 9 out of 15 patients) than MP-FLAIR (\u003ci\u003en\u003c/i\u003e = 25) and standard T1 (\u003ci\u003en\u003c/i\u003e = 23), which was associated with significant improvement of CNR (\u003ci\u003ep\u003c/i\u003e p = 0.003) with lower volumes found for the anteroventral (\u003ci\u003ep\u003c/i\u003e p p = 0.004) nuclei.Conclusion:WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://sage.figshare.com/collections/White-matter-nulled_MPRAGE_at_7T_reveals_thalamic_lesions_and_atrophy_of_specific_thalamic_nuclei_in_multiple_sclerosis/4402316","contentUrl":null,"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